Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1.

abstract：OBJECTIVE:To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies and a randomized controlled trial. METHODS:We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with s...

journal_title：Neurology

authors： Amato AA,Sivakumar K,Goyal N,David WS,Salajegheh M,Praestgaard J,Lach-Trifilieff E,Trendelenburg AU,Laurent D,Glass DJ,Roubenoff R,Tseng BS,Greenberg SA

更新日期：2014-12-09 00:00:00

abstract：OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...

journal_title：Neurology

authors： Servidei S,Capon F,Spinazzola A,Mirabella M,Semprini S,de Rosa G,Gennarelli M,Sangiuolo F,Ricci E,Mohrenweiser HW,Dallapiccola B,Tonali P,Novelli G

更新日期：1999-09-11 00:00:00

abstract：BACKGROUND:Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD. METHODS:We prospectively examined a...

journal_title：Neurology

authors： Gao X,Simon KC,Han J,Schwarzschild MA,Ascherio A

更新日期：2009-10-20 00:00:00

abstract：OBJECTIVE:To report 2 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented acutely with Miller Fisher syndrome and polyneuritis cranialis, respectively. METHODS:Patient data were obtained from medical records from the University Hospital "Príncipe de Asturias," Alcalá de He...

journal_title：Neurology

authors： Gutiérrez-Ortiz C,Méndez-Guerrero A,Rodrigo-Rey S,San Pedro-Murillo E,Bermejo-Guerrero L,Gordo-Mañas R,de Aragón-Gómez F,Benito-León J

更新日期：2020-08-04 00:00:00

abstract：:We performed a prospective clinical and electrophysiologic study of common peroneal (CP) neuropathy to evaluate the extent of involvement of the muscles and cutaneous areas supplied by this nerve. In 22 patients, seven had more weakness clinically in muscles innervated by the deep peroneal nerve than in those innervat...

journal_title：Neurology

authors： Sourkes M,Stewart JD

更新日期：1991-07-01 00:00:00

abstract：:We have studied one family of a pedigree in which bulbospinal muscular atrophy and protanopia were segregated. Genotypes for these disorders were obtained on three generations, and the maximum likelihood estimate of recombination fraction was 0.4 with the lod score method. The results indicated that the two loci are n...

journal_title：Neurology

authors： Mukai E,Yasuma T

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg daily vs the approved 20-mg formulation in relapsing-remitting multiple sclerosis. METHODS:Eligibility criteria included clinically definite multiple sclerosis, Expanded Disability Status Scale score 0 to 5.0, no previous use...

journal_title：Neurology

authors： Cohen JA,Rovaris M,Goodman AD,Ladkani D,Wynn D,Filippi M,9006 Study Group.

更新日期：2007-03-20 00:00:00

abstract：:A physically and intellectually normally developed boy had a resection of a lumbar myelomeningocele shortly after birth and a shunt was inserted for hydrocephalus. He died at age 12 years after a traffic accident. Autopsy disclosed a hyperplasia of the cerebellar vermis. An abnormal median-sagittal triangular fiber tr...

journal_title：Neurology

authors： Friede RL,Briner J

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...

journal_title：Neurology

authors： Jones LK Jr,Eggers SDZ,Capobianco DJ,Boes CJ

更新日期：2018-10-16 00:00:00

abstract：:Previous anatomic and physiologic studies suggest brainstem dysfunction in cranial-cervical dystonia. To further explore this, we studied suprathreshold acoustic reflex waveforms in 15 such patients. A unique feature of this technique is its ability to reject movement artifacts before averaging the acoustic reflex wav...

journal_title：Neurology

authors： Lew H,Jordan C,Jerger J,Jankovic J

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network. METHODS:We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated w...

journal_title：Neurology

authors： Fischer DB,Boes AD,Demertzi A,Evrard HC,Laureys S,Edlow BL,Liu H,Saper CB,Pascual-Leone A,Fox MD,Geerling JC

更新日期：2016-12-06 00:00:00

abstract：OBJECTIVE:Spontaneous spinal CSF leaks are an important cause of new-onset headaches. Such leaks are reported to be particularly common at the cervico-thoracic junction. The authors undertook a study to determine the significance of these cervico-thoracic CSF leaks. METHODS:The patient population consisted of a consec...

journal_title：Neurology

authors： Schievink WI,Maya MM,Chu RM,Moser FG

更新日期：2015-06-16 00:00:00

abstract：OBJECTIVE:We aimed to assess sensitivity and specificity of the updated criteria for behavioral variant frontotemporal dementia (bvFTD) based on a large autopsy-confirmed cohort of patients with dementia. METHODS:Two hundred thirty-nine consecutive pathologically confirmed dementia patients, clinically assessed in a s...

journal_title：Neurology

authors： Harris JM,Gall C,Thompson JC,Richardson AM,Neary D,du Plessis D,Pal P,Mann DM,Snowden JS,Jones M

更新日期：2013-05-14 00:00:00

abstract：:Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...

journal_title：Neurology

authors： Friedman D,French JA

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:Adiponectin is a protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic properties. In this study, we investigated the relationship between adiponectin levels and ischemic stroke subtype. METHODS:Using clinical, imaging, and laboratory data, 231 consecutive patient...

journal_title：Neurology

authors： Bang OY,Saver JL,Ovbiagele B,Choi YJ,Yoon SR,Lee KH

更新日期：2007-05-29 00:00:00

abstract：:We report the clinical and pathologic features of a patient with peripheral neuropathy that was the first clinical expression of cholesterol emboli syndrome (CES). Biopsy of skeletal muscle and peripheral nerve revealed cholesterol clefts in lumens of small arteries, necrotizing arteritis, and severe degeneration of p...

journal_title：Neurology

authors： Bendixen BH,Younger DS,Hair LS,Gutierrez C,Meyers ML,Homma S,Jaffe IA

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:To study and provide an update on the state of clinical research in neurology in the United States. METHODS:US American Academy of Neurology members and chairs of departments of neurology were surveyed regarding clinical research in 2016. NIH data on the neuroscience pipeline and extramural grant funding wer...

journal_title：Neurology

authors： Hall DA,Ramos AR,Gelfand JM,Videnovic A,Benatar M,Cahill C,Kluger BM,Goldman M

更新日期：2018-04-10 00:00:00

abstract：:Surgery is a safe and effective treatment for patients with temporal lobe epilepsy (TLE) who do not respond adequately to anticonvulsant medication and in whom the seizure generator can be identified and safely removed. Proton MR spectroscopic imaging (MRSI) can image and quantify neuronal damage in patients with TLE ...

journal_title：Neurology

authors： Cendes F,Andermann F,Dubeau F,Matthews PM,Arnold DL

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Parkinsonian signs such as gait disturbance, rigidity, bradykinesia, and tremor are common among individuals with dementia and are associated with negative outcomes, but little is known about parkinsonian signs among individuals with mild cognitive impairment (MCI). OBJECTIVE:To examine the extent to which ...

journal_title：Neurology

authors： Boyle PA,Wilson RS,Aggarwal NT,Arvanitakis Z,Kelly J,Bienias JL,Bennett DA

更新日期：2005-12-27 00:00:00

abstract：:The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) t...

journal_title：Neurology

authors： Bonafé L,Blau N,Burlina AP,Romstad A,Güttler F,Burlina AB

更新日期：2001-09-11 00:00:00

abstract：:The American Academy of Neurology has published a comprehensive review and guidelines for the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) for the first time since 2002. These guidelines represent the work of MS experts, patients, and guideline experts and are based on their review of randomize...

journal_title：Neurology

authors： Corboy JR,Weinshenker BG,Wingerchuk DM

更新日期：2018-06-12 00:00:00

abstract：:Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor. ...

journal_title：Neurology

authors： Sabra AF,Hallett M,Sudarsky L,Mullally W

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:To evaluate patients with early HIV-cognitive motor complex (HIV-CMC) for possible regional cerebral blood flow (rCBF) abnormalities on perfusion MRI (pMRI). BACKGROUND:Nuclear medicine techniques have demonstrated global and focal cerebral perfusion abnormalities in patients with HIV dementia. Ultrafast pMR...

journal_title：Neurology

authors： Chang L,Ernst T,Leonido-Yee M,Speck O

更新日期：2000-01-25 00:00:00

abstract：:Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...

journal_title：Neurology

authors： Dubinsky RM,Stein AC,Lyons K

更新日期：2000-06-27 00:00:00

abstract：:Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cyt...

journal_title：Neurology

authors： Sterman AB

更新日期：1982-09-01 00:00:00

abstract：OBJECTIVE:Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hormone production would result in loss of the known neuroprotective...

journal_title：Neurology

authors： James ML,Langefeld CD,Sekar P,Moomaw CJ,Elkind MSV,Worrall BB,Sheth KN,Martini SR,Osborne J,Woo D,ERICH Investigators.

更新日期：2017-09-05 00:00:00

abstract：OBJECTIVE:To describe and analyze etiologies, clinical presentations, therapeutic management, and outcomes of patients with acute encephalitis and identify outcome predictors. METHODS:We conducted a retrospective review of patients diagnosed with acute encephalitis at Mayo Clinic Rochester between January 2000 and Dec...

journal_title：Neurology

authors： Singh TD,Fugate JE,Rabinstein AA

更新日期：2015-01-27 00:00:00

abstract：:We retrospectively examined the clinical courses of 20 children with severe near-drowning and divided their outcomes into 3 groups: normal (4), persistent vegetative state (9), and dead (7). We reviewed serial blood glucose levels and cerebral blood flow measured by stable xenon computed tomography within the 1st 48 h...

journal_title：Neurology

authors： Ashwal S,Schneider S,Tomasi L,Thompson J

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls. METHODS:We included 64 patients with AD (67 +/- 9 years; F/M 38/26), 44 patients with MCI (71 +/- 6 yea...

journal_title：Neurology

authors： Henneman WJ,Sluimer JD,Barnes J,van der Flier WM,Sluimer IC,Fox NC,Scheltens P,Vrenken H,Barkhof F

更新日期：2009-03-17 00:00:00

abstract：:Antiacetylcholine receptor antibody (anti-AChR) was spontaneously synthesized by cultured thymic tissue from 19 of 35 patients with myasthenia gravis. Two other thymus cultures produced antibody after stimulation by pokeweed mitogen. Antibody production correlated with histologic evidence of thymitis, long duration of...

journal_title：Neurology

authors： Scadding GK,Vincent A,Newsom-Davis J,Henry K

更新日期：1981-08-01 00:00:00