Miller Fisher syndrome and polyneuritis cranialis in COVID-19.

Abstract:

OBJECTIVE:To report 2 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented acutely with Miller Fisher syndrome and polyneuritis cranialis, respectively. METHODS:Patient data were obtained from medical records from the University Hospital "Príncipe de Asturias," Alcalá de Henares, and the University Hospital "12 de Octubre," Madrid, Spain. RESULTS:A 50-year-old man presented with anosmia, ageusia, right internuclear ophthalmoparesis, right fascicular oculomotor palsy, ataxia, areflexia, albuminocytologic dissociation, and positive testing for anti-GD1b-immunoglobulin G antibody. Five days previously, he had developed a cough, malaise, headache, low back pain, and fever. A 39-year-old man presented with ageusia, bilateral abducens palsy, areflexia, and albuminocytologic dissociation. Three days previously, he had developed diarrhea, a low-grade fever, and poor general condition. Oropharyngeal swab test for SARS-CoV-2 by qualitative real-time reverse transcriptase PCR assay was positive in both patients and negative in the CSF. The first patient was treated with IV immunoglobulin and the second with acetaminophen. Two weeks later, both patients made a complete neurologic recovery, except for residual anosmia and ageusia in the first case. CONCLUSIONS:Our 2 cases highlight the rare occurrence of Miller Fisher syndrome and polyneuritis cranialis during the coronavirus disease 2019 (COVID-19) pandemic. These neurologic manifestations may occur because of an aberrant immune response to COVID-19. The full clinical spectrum of neurologic symptoms in patients with COVID-19 remains to be characterized.

journal_name

Neurology

journal_title

Neurology

authors

Gutiérrez-Ortiz C,Méndez-Guerrero A,Rodrigo-Rey S,San Pedro-Murillo E,Bermejo-Guerrero L,Gordo-Mañas R,de Aragón-Gómez F,Benito-León J

doi

10.1212/WNL.0000000000009619

subject

Has Abstract

pub_date

2020-08-04 00:00:00

pages

e601-e605

issue

5

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000009619

journal_volume

95

pub_type

杂志文章
  • Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels.

    abstract::Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.12.1401

    authors: Gal P,Toback J,Boer HR,Erkan NV,Wells TJ

    更新日期:1982-12-01 00:00:00

  • Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis.

    abstract:OBJECTIVE:To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS:Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004411

    authors: Rossi S,Studer V,Motta C,Polidoro S,Perugini J,Macchiarulo G,Giovannetti AM,Pareja-Gutierrez L,Calò A,Colonna I,Furlan R,Martino G,Centonze D

    更新日期:2017-09-26 00:00:00

  • The Pediatric Stroke Recurrence and Recovery Questionnaire: validation in a prospective cohort.

    abstract:OBJECTIVE:We developed the Recurrence and Recovery Questionnaire (RRQ) by converting the Pediatric Stroke Outcome Measure (PSOM) to a questionnaire for telephone interview and sought to validate the RRQ in a large cohort. METHOD:We analyzed parents' RRQ responses and same-day PSOM assessments for 232 children who had ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318266fc9a

    authors: Lo WD,Ichord RN,Dowling MM,Rafay M,Templeton J,Halperin A,Smith SE,Licht DJ,Moharir M,Askalan R,Deveber G,International Pediatric Stroke Study (IPSS) Investigators.

    更新日期:2012-08-28 00:00:00

  • Dyskinesia and the antiparkinsonian response always temporally coincide: a retrospective study.

    abstract:OBJECTIVE:To clinically characterize the temporal relationship between dyskinesia and the antiparkinsonian response when dyskinesia first emerges during long-term levodopa therapy and to determine if it is consistent with the hypothesized mechanism by which dyskinesia develops. METHODS:Dyskinesia and the antiparkinson...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181d90050

    authors: Nutt JG,Chung KA,Holford NH

    更新日期:2010-04-13 00:00:00

  • Changes in the ascertainment of multiple sclerosis.

    abstract:OBJECTIVE:With diagnostic criteria alterations, increased MRI availability, and awareness of therapies, temporal changes in incidence and prevalence rates may occur, with an increase in the proportion of mildly affected persons diagnosed with multiple sclerosis (MS). The authors assessed temporal trends in the delay fr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000178891.20579.64

    authors: Marrie RA,Cutter G,Tyry T,Hadjimichael O,Campagnolo D,Vollmer T

    更新日期:2005-10-11 00:00:00

  • Epilepsy in multiple sclerosis: A nationwide population-based register study.

    abstract:OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004740

    authors: Burman J,Zelano J

    更新日期:2017-12-12 00:00:00

  • Quantitative magnetic resonance characterization of mesial temporal sclerosis in childhood.

    abstract:OBJECTIVE:To investigate whether quantitative MR techniques can be used to distinguish between mesial temporal sclerosis in patients with a history of prolonged febrile convulsion and in patients without such a history. METHODS:Quantitative hippocampal T2 relaxometry, hippocampal volumetry, and single voxel (1)H-MRS d...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.12.1659

    authors: Scott RC,Gadian DG,Cross JH,Wood SJ,Neville BG,Connelly A

    更新日期:2001-06-26 00:00:00

  • The in vivo development of plasma cells: a morphologic study of human cerebrospinal fluid.

    abstract::This is a case study of a patient with the clinical diagnosis of meningoencephalitis. It demonstrates the in vivo development of plasma cells in the central nervous system. All the stages of in vitro mitogen-induced lymphocyte transformation previously described by light and electron microscopy are recapitulated in th...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.5.448

    authors: Glasser L,Payne C,Corrigan JJ Jr

    更新日期:1977-05-01 00:00:00

  • Neuroanatomic correlates of visual hallucinations in poststroke hemianopic patients.

    abstract:OBJECTIVES:Homonymous hemianopia (HH) is the most frequent visual-field defect after a stroke. Some of these patients also have visual hallucinations, the origin and frequency of which remain largely unknown. The aims of this work were to determine the occurrence of visual hallucinations among poststroke hemianopic pat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009366

    authors: Martinelli F,Perez C,Caetta F,Obadia M,Savatovsky J,Chokron S

    更新日期:2020-05-05 00:00:00

  • Blood neurofilament light levels segregate treatment effects in multiple sclerosis.

    abstract:OBJECTIVE:To determine factors (including the role of specific disease modulatory treatments [DMTs]) associated with (1) baseline, (2) on-treatment, and (3) change (from treatment start to on-treatment assessment) in plasma neurofilament light chain (pNfL) concentrations in relapsing-remitting multiple sclerosis (RRMS)...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009097

    authors: Delcoigne B,Manouchehrinia A,Barro C,Benkert P,Michalak Z,Kappos L,Leppert D,Tsai JA,Plavina T,Kieseier BC,Lycke J,Alfredsson L,Kockum I,Kuhle J,Olsson T,Piehl F

    更新日期:2020-03-17 00:00:00

  • Complex partial status epilepticus (psychomotor status).

    abstract::A 20-year-old mentally retarded woman, who had a history of intractable epileptic seizures since early childhood, had prolonged episodes of confusion, decreased responsiveness and automatic behavior lasting as long as 2 days. These are believed to represent epileptic status of the complex partial (psychomotor) type be...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.28.2.189

    authors: Markand ON,Wheeler GL,Pollack SL

    更新日期:1978-02-01 00:00:00

  • Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy.

    abstract:OBJECTIVE:Cell-based therapies are being investigated as an adjunct to IV thrombolysis or mechanical thrombectomy in ischemic stroke. This review summarizes the potential applications as well as challenges of intravascular cell delivery in ischemic stroke. METHOD:We conducted a search of Medline as well as the clinica...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e31826959d2

    authors: Misra V,Ritchie MM,Stone LL,Low WC,Janardhan V

    更新日期:2012-09-25 00:00:00

  • Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment.

    abstract:OBJECTIVE:Recent studies have suggested modifications of serotonin cerebral metabolism and of 5-HT(1A) receptors density in Alzheimer disease (AD). This study aims at exploring hippocampus 5-HT(1A) receptor density in patients at the amnesic mild cognitive impairment (aMCI) and mild AD dementia stages. METHODS:With us...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000271377.52421.4a

    authors: Truchot L,Costes SN,Zimmer L,Laurent B,Le Bars D,Thomas-Antérion C,Croisile B,Mercier B,Hermier M,Vighetto A,Krolak-Salmon P

    更新日期:2007-09-04 00:00:00

  • Inflammatory markers and cognition in well-functioning African-American and white elders.

    abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000073620.42047.d7

    authors: Yaffe K,Lindquist K,Penninx BW,Simonsick EM,Pahor M,Kritchevsky S,Launer L,Kuller L,Rubin S,Harris T

    更新日期:2003-07-08 00:00:00

  • Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial.

    abstract:OBJECTIVE:To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS:A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month intervals IV over a 2-year per...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000174439.70369.7a

    authors: Krapf H,Morrissey SP,Zenker O,Zwingers T,Gonsette R,Hartung HP,MIMS Study Group.

    更新日期:2005-09-13 00:00:00

  • Progressive parkinsonism associated with Rosenthal fibers: senile-onset Alexander's disease?

    abstract::Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.9.1733

    authors: Friedman JH,Ambler M

    更新日期:1992-09-01 00:00:00

  • A clinico-neurophysiological study of urogenital dysfunction in MOG-antibody transverse myelitis.

    abstract:OBJECTIVE:To assess the clinical, urodynamic, and neurophysiologic features of patients with persisting bladder, bowel, and sexual dysfunction after transverse myelitis in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease. METHODS:Patients with a history of MOG-Ab disease-related transverse myelitis seen p...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011030

    authors: Li V,Malladi P,Simeoni S,Pakzad M,Everett R,Satukijchai C,Leite MI,Palace J,Panicker JN

    更新日期:2020-11-24 00:00:00

  • Perfusion MRI detects rCBF abnormalities in early stages of HIV-cognitive motor complex.

    abstract:OBJECTIVE:To evaluate patients with early HIV-cognitive motor complex (HIV-CMC) for possible regional cerebral blood flow (rCBF) abnormalities on perfusion MRI (pMRI). BACKGROUND:Nuclear medicine techniques have demonstrated global and focal cerebral perfusion abnormalities in patients with HIV dementia. Ultrafast pMR...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.2.389

    authors: Chang L,Ernst T,Leonido-Yee M,Speck O

    更新日期:2000-01-25 00:00:00

  • Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.

    abstract::A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. S...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.WNL.0000156945.39471.2C

    authors: Antozzi C,Frassoni C,Vincent A,Regondi MC,Andreetta F,Bernasconi P,Ciano C,Chang T,Cornelio F,Spreafico R,Mantegazza R

    更新日期:2005-04-12 00:00:00

  • A controlled trial with vasopressin analogue (DGAVP) on cognitive recovery immediately after head trauma.

    abstract::Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, mat...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.43.1_part_1.103

    authors: Bohnen NI,Twijnstra A,Jolles J

    更新日期:1993-01-01 00:00:00

  • Petasites hybridus root (butterbur) is an effective preventive treatment for migraine.

    abstract:OBJECTIVE:To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine. METHODS:This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients wit...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000147290.68260.11

    authors: Lipton RB,Göbel H,Einhäupl KM,Wilks K,Mauskop A

    更新日期:2004-12-28 00:00:00

  • Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease.

    abstract:OBJECTIVE:To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000185

    authors: Zhu J,Wang Y,Li J,Deng J,Zhou H

    更新日期:2014-03-11 00:00:00

  • Optic neuritis: a population-based study in Olmsted County, Minnesota.

    abstract::We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regres...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.2.244

    authors: Rodriguez M,Siva A,Cross SA,O'Brien PC,Kurland LT

    更新日期:1995-02-01 00:00:00

  • Atherosclerotic carotid artery disease in patients with retinal ischemic syndromes.

    abstract::The extracranial carotid systems of 105 patients with retinal ischemia were examined using B-mode ultrasonography with integrated pulsed Doppler. Sixty-four patients had amaurosis fugax (AF), 17 central retinal artery occlusions (CRAO), and 21 branch retinal artery occlusions (BRAO). The prevalence of carotid stenosis...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.6.858

    authors: Chawluk JB,Kushner MJ,Bank WJ,Silver FL,Jamieson DG,Bosley TM,Conway DJ,Cohen D,Savino PJ

    更新日期:1988-06-01 00:00:00

  • Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging.

    abstract:OBJECTIVE:To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. METHODS:We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000939

    authors: Brier MR,Thomas JB,Snyder AZ,Wang L,Fagan AM,Benzinger T,Morris JC,Ances BM

    更新日期:2014-10-28 00:00:00

  • Pharmacology of dopamine agonists in the treatment of Parkinson's disease.

    abstract::There is now increasing use of dopamine agonists as effective early monotherapy in the treatment of Parkinson's disease (PD). Dopamine agonists can induce an antiparkinsonian effect through actions on either D(1)-like or D(2)-like dopamine receptors, and the multiple receptor subtypes present in the brain may provide ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.58.suppl_1.s1

    authors: Jenner P

    更新日期:2002-02-26 00:00:00

  • Hydromyelia associated with arrested hydrocephalus.

    abstract::A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.4.652

    authors: Olson DM,Milstein JM

    更新日期:1988-04-01 00:00:00

  • Plasmapheresis in acute episodes of fulminant CNS inflammatory demyelination.

    abstract::We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.6.1100

    authors: Rodriguez M,Karnes WE,Bartleson JD,Pineda AA

    更新日期:1993-06-01 00:00:00

  • Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. The Tolcapone Stable Study Group.

    abstract::In this double-blind, placebo-controlled trial, we investigated the effect of the catechol-O-methyltransferase inhibitor tolcapone 100 or 200 mg three times daily on activities of daily living and motor function in 298 patients with parkinsonism receiving levodopa but without motor fluctuations. At 6 months, both dosa...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.49.3.665

    authors: Waters CH,Kurth M,Bailey P,Shulman LM,LeWitt P,Dorflinger E,Deptula D,Pedder S

    更新日期:1997-09-01 00:00:00

  • Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission?

    abstract::Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy vo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.46.5.1404

    authors: Wang W,Timsit-Berthier M,Schoenen J

    更新日期:1996-05-01 00:00:00