Dyskinesia and the antiparkinsonian response always temporally coincide: a retrospective study.

abstract：OBJECTIVE:In addition to the main multiple sclerosis (MS) major histocompatibility complex (MHC) risk allele (HLA DRB1*1501), investigations of the MHC have implicated several class I MHC loci (HLA A, HLA B, and HLA C) as potential independent MS susceptibility loci. Here, we evaluate the role of 3 putative protective ...

journal_title：Neurology

authors： Healy BC,Liguori M,Tran D,Chitnis T,Glanz B,Wolfish C,Gauthier S,Buckle G,Houtchens M,Stazzone L,Khoury S,Hartzmann R,Fernandez-Vina M,Hafler DA,Weiner HL,Guttmann CR,De Jager PL

更新日期：2010-08-17 00:00:00

abstract：OBJECTIVE:To investigate clinical and economic consequences following generic substitution of one vs multiple generics of topiramate (Topamax; Ortho-McNeil Neurologics, Titusville, NJ). METHODS:Medical and pharmacy claims data of Régie de l'Assurance-Maladie du Québec from January 2006 to October 2007 were used. Patie...

journal_title：Neurology

authors： Duh MS,Paradis PE,Latrémouille-Viau D,Greenberg PE,Lee SP,Durkin MB,Wan GJ,Rupnow MF,LeLorier J

更新日期：2009-06-16 00:00:00

abstract：OBJECTIVE:To preliminarily assess the safety and efficacy of transdermal nicotine therapy on cognitive performance and clinical status in subjects with mild cognitive impairment (MCI). METHODS:Nonsmoking subjects with amnestic MCI were randomized to transdermal nicotine (15 mg per day or placebo) for 6 months. Primary...

journal_title：Neurology

authors： Newhouse P,Kellar K,Aisen P,White H,Wesnes K,Coderre E,Pfaff A,Wilkins H,Howard D,Levin ED

更新日期：2012-01-10 00:00:00

abstract：:We studied the effects of acute ethanol intoxication on platelet function, coagulation factors, and fibrinolytic activity in 12 healthy men. During the ethanol session, 10 of the 12 developed a transient decrease in fibrinolytic activity. Ethanol ingestion increased factor VIII coagulant activity. VIII-related antigen...

journal_title：Neurology

authors： Hillbom M,Kaste M,Rasi V

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:To investigate the association between early depressive behavior after stroke onset and occurrence of poststroke depression (PSD) at 3- and 12-month follow-up evaluations. METHODS:The study prospectively included 273 patients with first-ever single uncomplicated ischemic stroke. In the stroke unit, nurses sc...

journal_title：Neurology

authors： Carota A,Berney A,Aybek S,Iaria G,Staub F,Ghika-Schmid F,Annable L,Guex P,Bogousslavsky J

更新日期：2005-02-08 00:00:00

abstract：BACKGROUND:Oculopharyngodistal myopathy (OPDM) has been reported as a rare, adult-onset hereditary muscle disease with putative autosomal dominant and autosomal recessive inheritance. Patients with OPDM present with progressive ocular, pharyngeal, and distal limb muscle involvement. The genetic defect causing OPDM has ...

journal_title：Neurology

authors： Durmus H,Laval SH,Deymeer F,Parman Y,Kiyan E,Gokyigiti M,Ertekin C,Ercan I,Solakoglu S,Karcagi V,Straub V,Bushby K,Lochmüller H,Serdaroglu-Oflazer P

更新日期：2011-01-18 00:00:00

abstract：OBJECTIVE:To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS:In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled wi...

journal_title：Neurology

authors： Peterlin BL,Mielke MM,Dickens AM,Chatterjee S,Dash P,Alexander G,Vieira RV,Bandaru VV,Dorskind JM,Tietjen GE,Haughey NH

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. METHODS:To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgica...

journal_title：Neurology

authors： Janszky J,Jokeit H,Schulz R,Hoppe M,Ebner A

更新日期：2000-04-11 00:00:00

abstract：OBJECTIVE:Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrot...

journal_title：Neurology

authors： Pinal-Fernandez I,Casal-Dominguez M,Derfoul A,Pak K,Plotz P,Miller FW,Milisenda JC,Grau-Junyent JM,Selva-O'Callaghan A,Paik J,Albayda J,Christopher-Stine L,Lloyd TE,Corse AM,Mammen AL

更新日期：2019-09-17 00:00:00

abstract：:Apraxia is the loss of the ability to perform learned skilled movements correctly. In right-handers, apraxia and aphasia are most frequently associated with left-hemisphere lesions. When they are dissociated, however, aphasia is more common in the absence of apraxia than vice versa. There are two hypotheses that can a...

journal_title：Neurology

authors： Foundas AL,Henchey R,Gilmore RL,Fennell EB,Heilman KM

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:In a recent study, the authors found that blinks in healthy volunteers always triggered ocular torsion quick phases during dynamic roll movements of the head. On the basis of this observation, they hypothesized that blinks in patients with a vestibular tone imbalance would also trigger torsional quick phases...

journal_title：Neurology

authors： Schneider E,Glasauer S,Dieterich M,Kalla R,Brandt T

更新日期：2004-10-12 00:00:00

abstract：:Parry-Romberg syndrome (PRS) is a rare neurocutaneous disorder characterized by progressive facial hemiatrophy. In this study, 205 patients with PRS were surveyed using the Internet. Estimates of the frequency of limb involvement (19%), epilepsy (11%), and other clinical and etiologic features were obtained. There was...

journal_title：Neurology

authors： Stone J

更新日期：2003-09-09 00:00:00

abstract：:Management of low-grade gliomas continues to be a challenging task, because CT and MRI do not always differentiate from nontumoral lesions. Furthermore, tumor extent and aggressiveness often remain unclear because of a lack of contrast enhancement. Previous studies indicated that large neutral amino acid tracers accum...

journal_title：Neurology

authors： Herholz K,Hölzer T,Bauer B,Schröder R,Voges J,Ernestus RI,Mendoza G,Weber-Luxenburger G,Löttgen J,Thiel A,Wienhard K,Heiss WD

更新日期：1998-05-01 00:00:00

abstract：:We studied 25 patients within 6 hours of acute spinal cord injury using magnetically evoked cortical motor evoked potentials (MEPs). The subjects included 16 quadriplegics with cervical spine injuries and eight paraplegics. MEPs were recorded from abductor digiti minimi (ADM), biceps, flexor hallucis brevis, and tibia...

journal_title：Neurology

authors： Macdonell RA,Donnan GA

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of amyloid imaging on clinical decision making. METHODS:We conducted a retrospective analysis of 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.3) who underwent amyloid (Pittsburgh compound B [PiB]) PE...

journal_title：Neurology

authors： Sánchez-Juan P,Ghosh PM,Hagen J,Gesierich B,Henry M,Grinberg LT,O'Neil JP,Janabi M,Huang EJ,Trojanowski JQ,Vinters HV,Gorno-Tempini M,Seeley WW,Boxer AL,Rosen HJ,Kramer JH,Miller BL,Jagust WJ,Rabinovici GD

更新日期：2014-01-21 00:00:00

abstract：OBJECTIVE:To perform a meta-analysis of 4 core CSF biomarkers (β-amyloid [Aβ]42, Aβ40, total tau [t-tau], and phosphorylated tau [p-tau]) to assess which of these are most altered in sporadic cerebral amyloid angiopathy (CAA). METHODS:We systematically searched PubMed for eligible studies reporting data on CSF biomark...

journal_title：Neurology

authors： Charidimou A,Friedrich JO,Greenberg SM,Viswanathan A

更新日期：2018-02-27 00:00:00

abstract：OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...

journal_title：Neurology

authors： Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.

更新日期：2012-11-13 00:00:00

abstract：OBJECTIVE:To examine whether blast exposure alone and blast-associated concussion result in similar neurologic and mental health symptoms. METHODS:A 14-item questionnaire was administered to male US Marines on their return from deployment in Iraq and/or Afghanistan. RESULTS:A total of 2,612 Marines (median age 22 yea...

journal_title：Neurology

authors： Tsao JW,Stentz LA,Rouhanian M,Howard RS,Perry BN,Haran FJ,Pasquina PF,Wolde M,Taylor CE,Lizardo R,Liu S,Flores E 3rd,Creason AH,Sher K

更新日期：2017-11-07 00:00:00

abstract：:The effects of lysine vasopressin on memory and cognitive deficits in Alzheimer disease was investigated. In a double-blind study, seven patients were given 16 units of lysine vasopressin per day for 10 days and were compared with seven different patients receiving placebo. No significant difference in performance bet...

journal_title：Neurology

authors： Durso R,Fedio P,Brouwers P,Cox C,Martin AJ,Ruggieri SA,Tamminga CA,Chase TN

更新日期：1982-06-01 00:00:00

abstract：OBJECTIVE:To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS:In 1993, 233 patients with PD were included in a community-based study of fatigue and followed...

journal_title：Neurology

authors： Alves G,Wentzel-Larsen T,Larsen JP

更新日期：2004-11-23 00:00:00

abstract：BACKGROUND:Periodic paralyses and paramyotonia congenita are rare disorders causing disabling weakness and myotonia. Mutations in sodium, calcium, and potassium channels have been recognized as causing disease. OBJECTIVE:To analyze the clinical phenotype of patients with and without discernible genotype and to identif...

journal_title：Neurology

authors： Miller TM,Dias da Silva MR,Miller HA,Kwiecinski H,Mendell JR,Tawil R,McManis P,Griggs RC,Angelini C,Servidei S,Petajan J,Dalakas MC,Ranum LP,Fu YH,Ptácek LJ

更新日期：2004-11-09 00:00:00

abstract：OBJECTIVE:To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample. METHODS:Retroactive application of MCI criteria to data collected during a prospective epidemiologic study was performed. The subjects were dr...

journal_title：Neurology

authors： Ganguli M,Dodge HH,Shen C,DeKosky ST

更新日期：2004-07-13 00:00:00

abstract：OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...

journal_title：Neurology

authors： Ryu DW,Shon YM,Kim BS,Cho AH

更新日期：2012-05-01 00:00:00

abstract：:A man with onset of obsessive-compulsive disorder (OCD) at age 62 had a large right posterior frontal infarct and occlusion of the ipsilateral internal carotid artery. We review additional cases from the literature with obsessive or compulsive behaviors and structural lesions. OCD may have a structural correlate, and ...

journal_title：Neurology

authors： Swoboda KJ,Jenike MA

更新日期：1995-12-01 00:00:00

abstract：:Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for eac...

journal_title：Neurology

authors： Engel J Jr,Kuhl DE,Phelps ME,Rausch R,Nuwer M

更新日期：1983-04-01 00:00:00

abstract：:We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most...

journal_title：Neurology

authors： Bresolin N,Bet L,Binda A,Moggio M,Comi G,Nador F,Ferrante C,Carenzi A,Scarlato G

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...

journal_title：Neurology

authors： McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH

更新日期：2012-05-29 00:00:00

abstract：OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...

journal_title：Neurology

authors： Servidei S,Capon F,Spinazzola A,Mirabella M,Semprini S,de Rosa G,Gennarelli M,Sangiuolo F,Ricci E,Mohrenweiser HW,Dallapiccola B,Tonali P,Novelli G

更新日期：1999-09-11 00:00:00

abstract：:Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...

journal_title：Neurology

authors： Saito K,Otsuki M,Ueno S

更新日期：2007-10-02 00:00:00

abstract：BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...

journal_title：Neurology

authors： Bandaru VV,McArthur JC,Sacktor N,Cutler RG,Knapp EL,Mattson MP,Haughey NJ

更新日期：2007-05-01 00:00:00