Abstract:
:We studied the effects of acute ethanol intoxication on platelet function, coagulation factors, and fibrinolytic activity in 12 healthy men. During the ethanol session, 10 of the 12 developed a transient decrease in fibrinolytic activity. Ethanol ingestion increased factor VIII coagulant activity. VIII-related antigen, and VIII-ristocetin cofactor. The highest levels were detected 16 hours after beginning ethanol ingestion (p less than 0.001), and the bleeding time decreased at 12 hours (p less than 0.01). Ethanol had no effects on platelet count, beta-thromboglobulin, antithrombin III, ethanol gelation, or fibrin/fibrinogen degradation products. Decreased fibrinolytic activity, increased factor VIII complex, and shortened bleeding time may explain why ethanol intoxication increases susceptibility to cerebral thrombosis.
journal_name
Neurologyjournal_title
Neurologyauthors
Hillbom M,Kaste M,Rasi Vdoi
10.1212/wnl.33.3.381subject
Has Abstractpub_date
1983-03-01 00:00:00pages
381-4issue
3eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
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