Abstract:
:We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a wheelchair. Diabetes was considered to be an outcome variable when defining time to diabetes and an explanatory variable when testing its effect on survival. Eleven patients died. The median estimated survival from onset was 36 years, and the median time to loss of independent gait was 8 years and to confinement in a wheelchair was 15 years from onset. Nineteen patients developed diabetes after a median time of 16 years. The presence of left ventricular hypertrophy or diabetes significantly reduced survival based on univariate analysis. Onset at the age of < or = 20 years and the presence of left ventricular hypertrophy predicted a faster rate of progression of the disease.
journal_name
Neurologyjournal_title
Neurologyauthors
De Michele G,Perrone F,Filla A,Mirante E,Giordano M,De Placido S,Campanella Gdoi
10.1212/wnl.47.5.1260subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1260-4issue
5eissn
0028-3878issn
1526-632Xjournal_volume
47pub_type
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