The practice of neurology: Looking ahead by looking back.

abstract：:Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...

journal_title：Neurology

authors： Rutgers MJ,van der Lugt PJ,van Turnhout JM

更新日期：1979-04-01 00:00:00

abstract：:The initial decision in the management of idiopathic parkinsonism is whether any pharmacotherapy is indicated. There is no conclusive evidence that treatment is helpful before symptoms start to affect the patient's life, although some neurologists believe that deprenyl, also known as selegiline, could be useful. Once ...

journal_title：Neurology

authors： Calne DB

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Apoptosis, or programmed cell death, is an evolutionary conserved mechanism essential for morphogenesis and tissue homeostasis, but it plays an important role also in pathologic conditions, including neurologic disorders. Its execution pathway is critically regulated at the mitochondrial level. Evi...

journal_title：Neurology

authors： Sciacco M,Fagiolari G,Lamperti C,Messina S,Bazzi P,Napoli L,Chiveri L,Prelle A,Comi GP,Bresolin N,Scarlato G,Moggio M

更新日期：2001-04-24 00:00:00

abstract：OBJECTIVE:To compare nondemented patients with Parkinson's disease (PD) with and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness and REM sleep. METHODS:Fifteen patients with PD (7 patients with polysomnographic-confirmed RBD [PD-RBD] and 8 patients...

journal_title：Neurology

authors： Gagnon JF,Fantini ML,Bédard MA,Petit D,Carrier J,Rompré S,Décary A,Panisset M,Montplaisir J

更新日期：2004-02-10 00:00:00

abstract：BACKGROUND:Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. OBJECTIVE:T...

journal_title：Neurology

authors： Videler AJ,van Dijk JP,Beelen A,de Visser M,Nollet F,van Schaik IN

更新日期：2008-10-14 00:00:00

abstract：:We developed a rating scale for tic disorders that uses only objective criteria and accommodates the variety of tic manifestations. Using short videotaped recordings with the examiner out of the taping room, we measured five tic variables: number of body areas affected, frequency of motor tics and vocalizations, and s...

journal_title：Neurology

authors： Goetz CG,Tanner CM,Wilson RS,Shannon KM

更新日期：1987-09-01 00:00:00

abstract：:There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths wer...

journal_title：Neurology

authors： Shinotoh H,Calne DB,Snow B,Hayward M,Kremer B,Theilmann J,Hayden MR

更新日期：1994-11-01 00:00:00

abstract：:The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds ...

journal_title：Neurology

authors： Hauser SL,Oksenberg JR,Lincoln R,Garovoy J,Beck RW,Cole SR,Moke PS,Kip KE,Gal RL,Long DT

更新日期：2000-05-09 00:00:00

abstract：:The authors measured the association of early ischemic change on CT scan, measured using the Alberta Stroke Programme Early CT score (ASPECTS), and functional outcome in 825 patients with anterior circulation stroke treated with IV thrombolysis within 3 hours of onset. ASPECTS predicted outcome in a graded fashion (li...

journal_title：Neurology

authors： Weir NU,Pexman JH,Hill MD,Buchan AM,CASES investigators.

更新日期：2006-08-08 00:00:00

abstract：:The intracarotid amobarbital test (IAT) examines hemispheric memory and language. We set out to determine whether memory performance on the IAT correlated with seizure relief after anterior temporal lobectomy in 117 patients with refractory epilepsy. The IAT assessed recognition memory performance for nine items with ...

journal_title：Neurology

authors： Sperling MR,Saykin AJ,Glosser G,Moran M,French JA,Brooks M,O'Connor MJ

更新日期：1994-12-01 00:00:00

abstract：:Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other form...

journal_title：Neurology

authors： George MS,Nahas Z,Bohning DE,Kozel FA,Anderson B,Chae JH,Lomarev M,Denslow S,Li X,Mu C

更新日期：2002-09-24 00:00:00

abstract：:The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relativ...

journal_title：Neurology

authors： Floel A,Hummel F,Breitenstein C,Knecht S,Cohen LG

更新日期：2005-08-09 00:00:00

abstract：OBJECTIVE:The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level ...

journal_title：Neurology

authors： Schulte LH,Allers A,May A

更新日期：2018-05-29 00:00:00

abstract：:We evaluated the relationship between mesial temporal seizure focus and serum prolactin (PRL) in patients before and after they underwent anterior temporal lobectomy (ATL) for medically intractable temporal lobe epilepsy (TLE). These patients had a confirmed unilateral epileptogenic focus in mesial temporal structures...

journal_title：Neurology

authors： Lin YY,Su MS,Yiu CH,Shih YH,Yen DJ,Kwan SY,Wu ZA,Chan SH

更新日期：1997-08-01 00:00:00

abstract：:A 41-year-old man presented with bilateral posterior cerebral artery infarcts. He had visual object agnosia and prosopagnosia with preservation of reading abilities. There was also defective visual memory, topographic orientation, and color perception, as well as simultanagnosia. From the clinical facts and CT finding...

journal_title：Neurology

authors： Gomori AJ,Hawryluk GA

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:Brain atrophy is common in subcortical ischemic vascular disease, but the underlying mechanisms are poorly understood. We set out to examine the effects of incident subcortical infarcts on cortical morphology. METHODS:A total of 276 subjects with cerebral autosomal dominant arteriopathy with subcortical infa...

journal_title：Neurology

authors： Duering M,Righart R,Csanadi E,Jouvent E,Hervé D,Chabriat H,Dichgans M

更新日期：2012-11-13 00:00:00

abstract：OBJECTIVE:To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD). METHODS:The authors performed a systematic review of the available literature from 1995 to January 1, 2011, to identify articles involving patie...

journal_title：Neurology

authors： Muayqil T,Gronseth G,Camicioli R

更新日期：2012-10-02 00:00:00

abstract：OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...

journal_title：Neurology

authors： Wilson RS,Capuano AW,Boyle PA,Hoganson GM,Hizel LP,Shah RC,Nag S,Schneider JA,Arnold SE,Bennett DA

更新日期：2014-08-19 00:00:00

abstract：:All but 6% of the subjects with relapsing remitting MS who were randomly assigned to receive glatiramer acetate or placebo for the 9-month controlled phase of the European/Canadian MRI trial entered an open-label extension with quarterly clinical and MRI evaluations for another 9 months. There was a 54% reduction in t...

journal_title：Neurology

authors： Wolinsky JS,Comi G,Filippi M,Ladkani D,Kadosh S,Shifroni G,European\/Canadian Glatiramer Acetate Study Group.

更新日期：2002-10-22 00:00:00

abstract：OBJECTIVE:To investigate long-term employment outcomes after resective epilepsy surgery in a national population-based cohort of adults. METHODS:In the Swedish National Epilepsy Surgery Register, all adults who were operated with resective epilepsy surgery from 1995 to 2010 were identified. Two-year follow-up was avai...

journal_title：Neurology

authors： Edelvik A,Flink R,Malmgren K

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis of prodromal and probable AD. METHODS:Using a newly validated visual rating system, mean MTA scores of three bilate...

journal_title：Neurology

authors： Duara R,Loewenstein DA,Potter E,Appel J,Greig MT,Urs R,Shen Q,Raj A,Small B,Barker W,Schofield E,Wu Y,Potter H

更新日期：2008-12-09 00:00:00

abstract：:Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive supranuclear palsy (PSP) and 4 controls. ChAT-immunoreactive neurons were quantified in sections that spanned the rostrocaudal extent of each nucleus. In PSP, t...

journal_title：Neurology

authors： Juncos JL,Hirsch EC,Malessa S,Duyckaerts C,Hersh LB,Agid Y

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:Based on the hippocampus disconnection hypothesis in Alzheimer disease (AD), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes in hippocampus activity, we suggested that in patients with AD, the more the intrinsic functional connectivity between hippocampus and p...

journal_title：Neurology

authors： Tahmasian M,Pasquini L,Scherr M,Meng C,Förster S,Mulej Bratec S,Shi K,Yakushev I,Schwaiger M,Grimmer T,Diehl-Schmid J,Riedl V,Sorg C,Drzezga A

更新日期：2015-05-12 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of upper extremity virtual reality rehabilitation training (VR) to time-matched conventional training (CT) in the subacute phase after stroke. METHODS:In this randomized, controlled, single-blind phase III multicenter trial, 120 participants with upper extremity motor impairment ...

journal_title：Neurology

authors： Brunner I,Skouen JS,Hofstad H,Aßmus J,Becker F,Sanders AM,Pallesen H,Qvist Kristensen L,Michielsen M,Thijs L,Verheyden G

更新日期：2017-12-12 00:00:00

abstract：:Azathioprine has the longest continuing history of clinical use in the treatment of multiple sclerosis (MS) of any immunosuppressive therapy besides corticosteroids. To date, 19 clinical trials of azathioprine in MS have been reported, and another eight are under way. A review of the reported trials indicates little e...

journal_title：Neurology

authors： Silberberg DH

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To use the large dataset from the Tysabri Outreach: Unified Commitment to Health (TOUCH) program to compare progressive multifocal leukoencephalopathy (PML) risk with natalizumab extended interval dosing (EID) vs standard interval dosing (SID) in patients with multiple sclerosis (MS). METHODS:This retrospect...

journal_title：Neurology

authors： Ryerson LZ,Foley J,Chang I,Kister I,Cutter G,Metzger RR,Goldberg JD,Li X,Riddle E,Smirnakis K,Kasliwal R,Ren Z,Hotermans C,Ho PR,Campbell N

更新日期：2019-10-08 00:00:00

abstract：BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorienta...

journal_title：Neurology

authors： Monacelli AM,Cushman LA,Kavcic V,Duffy CJ

更新日期：2003-12-09 00:00:00

abstract：BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...

journal_title：Neurology

authors： Bandaru VV,McArthur JC,Sacktor N,Cutler RG,Knapp EL,Mattson MP,Haughey NJ

更新日期：2007-05-01 00:00:00

abstract：:We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most...

journal_title：Neurology

authors： Bresolin N,Bet L,Binda A,Moggio M,Comi G,Nador F,Ferrante C,Carenzi A,Scarlato G

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:In addition to the main multiple sclerosis (MS) major histocompatibility complex (MHC) risk allele (HLA DRB1*1501), investigations of the MHC have implicated several class I MHC loci (HLA A, HLA B, and HLA C) as potential independent MS susceptibility loci. Here, we evaluate the role of 3 putative protective ...

journal_title：Neurology

authors： Healy BC,Liguori M,Tran D,Chitnis T,Glanz B,Wolfish C,Gauthier S,Buckle G,Houtchens M,Stazzone L,Khoury S,Hartzmann R,Fernandez-Vina M,Hafler DA,Weiner HL,Guttmann CR,De Jager PL

更新日期：2010-08-17 00:00:00