Abstract:
:The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI.
journal_name
Neurologyjournal_title
Neurologyauthors
Hauser SL,Oksenberg JR,Lincoln R,Garovoy J,Beck RW,Cole SR,Moke PS,Kip KE,Gal RL,Long DTdoi
10.1212/wnl.54.9.1859subject
Has Abstractpub_date
2000-05-09 00:00:00pages
1859-61issue
9eissn
0028-3878issn
1526-632Xjournal_volume
54pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827deb63
更新日期:2013-01-15 00:00:00
abstract::Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS fr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000162033.47893.F7
更新日期:2005-05-24 00:00:00
abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1028
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003942
更新日期:2017-05-16 00:00:00
abstract::Quantitative studies of the afferent pathways from hollow viscera have been limited by the lack of an easily controlled, reproducible visceral stimulus. We adapted a slow distention device to allow for rapid distention to study the afferent pathways from the rectum. The device produced a pressure increase of 10 mm Hg ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.8.1510
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery. METHODS:We developed and tested an online system that exploits ECoG's temporal resolution...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002525
更新日期:2016-03-29 00:00:00
abstract:OBJECTIVE:To review clinical and electrodiagnostic features of the medial brachial fascial compartment syndrome, a complication of percutaneous axillary vessel puncture. METHODS:The authors reviewed electrodiagnostic examinations over a 20-year period. RESULTS:This syndrome presents with weakness, pain, and numbness ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000089488.35632.08
更新日期:2003-10-28 00:00:00
abstract::Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with 125I-protein A. The mean binding of 125I-protein A to oligodendrocyte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.540
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000115097.61748.bf
更新日期:2004-03-23 00:00:00
abstract::We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia and delusion. Neurologic examination revealed dementia and emotional instability, indifference, and confabulation. There was also mild spasticity of the bilateral lower limbs. MRI revealed diffuse white mat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000123117.11264.0e
更新日期:2004-05-11 00:00:00
abstract:OBJECTIVE:To characterize the nature and degree of cognitive morbidity in patients with chronic temporal lobe epilepsy compared with healthy control subjects, determine the association between the duration of epilepsy and cognitive morbidity, and ascertain whether there are factors that moderate the association between...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125186.04867.34
更新日期:2004-05-25 00:00:00
abstract:OBJECTIVE:To describe the phenotype of adult patients with variant and classic ataxia-telangiectasia (A-T), to raise the degree of clinical suspicion for the diagnosis variant A-T, and to assess a genotype-phenotype relationship for mutations in the ATM gene. METHODS:Retrospective analysis of the clinical characterist...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181af33bd
更新日期:2009-08-11 00:00:00
abstract::In muscles with sustained voluntary contraction, EMG activity is transiently inhibited after transcranial magnetic stimulation. We recorded this postexcitatory silent period (SP) at 1.5 times individual stimulus threshold level from the first dorsal interosseus muscle in 65 neurologic patients aged 11 to 80 years. Whe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.5.936
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:Structural and functional lesion localization in patients with hemispatial neglect. DESIGN:Location and severity of brain damage on CT and SPECT correlated with neglect performance as assessed with a battery of drawings, line bisection, and line and shape cancellation subtests. PATIENTS:Participants include...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.901
更新日期:1998-04-01 00:00:00
abstract::The authors report an autosomal dominant episodic ataxia that is clinically distinct from the other episodic ataxias. Vestibular ataxia, vertigo, tinnitus, and interictal myokymia are prominent; attacks are diminished by acetazolamide. Linkage analyses of markers flanking the EA1 and EA2 loci demonstrate genetic exclu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.8.1499
更新日期:2001-10-23 00:00:00
abstract::Butyrylcholinesterase is implicated in the pathology of AD. Selective inhibitors increase acetylcholine and improve cognitive function in animal models. In dementia with Lewy bodies, cholinergic activities are more affected than in AD. The authors report a highly significant association between temporal cortex butyryl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000068336.84399.9e
更新日期:2003-06-10 00:00:00
abstract:OBJECTIVE:To identify the level of evidence for use of nusinersen to treat spinal muscular atrophy (SMA) and review clinical considerations regarding use. METHODS:The author panel systematically reviewed nusinersen clinical trials for patients with SMA and assigned level of evidence statements based on the American Ac...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006502
更新日期:2018-11-13 00:00:00
abstract:OBJECTIVE:To investigate the relationship between baseline hypertension and severity of white matter hyperintensities (WMH) at 4-year follow-up in a sample of subjects aged 59 to 71 years old at entry. METHODS:Subjects were participants in the Epidemiology of Vascular Ageing study, a longitudinal study on vascular agi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.7.921
更新日期:2001-04-10 00:00:00
abstract::Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.653
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003696
更新日期:2017-03-14 00:00:00
abstract::We report a Jewish family of Yemenite origin in which three brothers born from a consanguineous marriage had juvenile parkinsonism. The DNA samples from three affected brothers and one healthy brother were analyzed for the linkage to markers covering the autosomal-recessive juvenile parkinsonism (AR-JP) locus. A perfe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1602
更新日期:1999-10-22 00:00:00
abstract:OBJECTIVE:To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN:The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.4.1000
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the association between spinal cord injury (SCI) and type 2 diabetes in a large representative sample and to determine whether an association exists irrespective of known risk factors for type 2 diabetes. METHODS:Data were obtained on 60,678 respondents to the Stat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436074.98534.6e
更新日期:2013-11-19 00:00:00
abstract:OBJECTIVE:To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. METHODS:The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000216259.99811.50
更新日期:2006-05-23 00:00:00
abstract::We compared CT and MRI findings among 78 Alzheimer's disease (AD), 66 vascular dementia (VaD), and 41 stroke without dementia (SWD) African-American patients to identify possible neuroimaging indicators of dementia. The patients with AD and VaD were generally older and less educated than those with SWD. VaD and SWD pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.8.1456
更新日期:1995-08-01 00:00:00
abstract::We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.2.412
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To use a historical placebo control design to determine whether lithium carbonate slows progression of amyotrophic lateral sclerosis (ALS). METHODS:A phase II trial was conducted at 10 sites in the Western ALS Study Group using similar dosages (300-450 mg/day), target blood levels (0.3-0.8 mEq/L), outcome me...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31822dc7a5
更新日期:2011-09-06 00:00:00
abstract::Childhood absence epilepsy (CAE) is defined by absence seizures in a normally developing child, with onset between 4 and 10 years of age.(1) Typical absence seizures consist of behavioral arrest with or without automatisms, usually last 30-60 seconds, and demonstrate a characteristic 3-Hz generalized spike-wave (GSW) ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000380
更新日期:2014-05-06 00:00:00
abstract::Supporting young people with pediatric multiple sclerosis can be challenging for families and health care providers. Adolescents may be more resilient than adults in reaction to the diagnosis but can have more difficulty planning for their futures. Appropriate, sensitive, and focused health provision should include co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002879
更新日期:2016-08-30 00:00:00
abstract:OBJECTIVE:To characterize brain functional connectivity in subjects with prechiasmatic visual system damage and relate functional connectivity features to extent of vision loss. METHODS:In this case-control study, resting-state, eyes-closed EEG activity was recorded in patients with partial optic nerve damage (n = 15)...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000672
更新日期:2014-08-05 00:00:00