Abstract:
BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorientation by comparing the performance of normal young (YN), middle-aged (MA), older adult (OA), and AD subjects on neuropsychological and spatial orientation tests. RESULTS:The tendency to become lost is shared by almost all patients with AD (93%) and some OA subjects (38%). This impairment is not related to memory impairment. Instead, it reflects an inability to link recognized scenes with locations in the environment. CONCLUSIONS:Spatial disorientation reflects the impaired linking of landmarks and routes that should be assessed in conjunction with routine memory testing in elderly patients.
journal_name
Neurologyjournal_title
Neurologyauthors
Monacelli AM,Cushman LA,Kavcic V,Duffy CJdoi
10.1212/wnl.61.11.1491subject
Has Abstractpub_date
2003-12-09 00:00:00pages
1491-7issue
11eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
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