Expression of cytokines in brain lesions in subacute sclerosing panencephalitis.

Abstract:

:We analyzed frozen brain specimens from three patients with subacute sclerosing panencephalitis (SSPE) for the presence of interleukin (IL)-1 beta, IL-2, IL-6, tumor necrosis factor (TNF), lymphotoxin (LT), and interferon (IFN)-gamma using immunocytochemical techniques. We detected these cytokines in SSPE brain lesions demonstrating extensive cellular infiltrates, demyelination, and gliosis. Double-label immunocytochemistry, using cell-specific markers, showed that positive immunoreactivity for these cytokines was present on both infiltrating cells and resident brain cells. We also found IL-6, TNF, and IFN-gamma at lower levels in brain tissue from a patient with progressive multifocal leukoencephalopathy. In contrast, normal control brain sections showed no reactivity for any of the cytokines. These findings indicate that IL-1 beta, IL-2, IL-6, TNT, LT, and IFN-gamma may be produced in SSPE lesions and may be involved in the lesion pathogenesis of SSPE.

journal_name

Neurology

journal_title

Neurology

authors

Nagano I,Nakamura S,Yoshioka M,Onodera J,Kogure K,Itoyama Y

doi

10.1212/wnl.44.4.710

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

710-5

issue

4

eissn

0028-3878

issn

1526-632X

journal_volume

44

pub_type

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