Proportional anterior commissure area in humans and monkeys.


:Behavioral testing following division of the corpus callosum has shown that the anterior commissure can transfer information related to visual tasks interhemispherically in nonhuman primates but not in humans. We have found that the ratio of anterior commissure cross-sectional area to total neocortical commissural area is significantly greater for rhesus monkeys than for humans. This difference persists when the proportions are weighted for these structures' known differences in axon density. We hypothesize that this interspecies dissimilarity reflects a difference in the distribution of interhemispheric communication and may explain the behavioral differences observed after callosal section.






Foxman BT,Oppenheim J,Petito CK,Gazzaniga MS




Has Abstract


1986-11-01 00:00:00












  • Tissue inhibitor metalloproteinase-1 and clinical outcomes after acute ischemic stroke.

    abstract:OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...


    pub_type: 杂志文章


    authors: Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

    更新日期:2019-10-29 00:00:00

  • Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study.

    abstract:OBJECTIVE:(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whet...


    pub_type: 杂志文章


    authors: Huang W,Alexander GE,Chang L,Shetty HU,Krasuski JS,Rapoport SI,Schapiro MB

    更新日期:2001-08-28 00:00:00

  • Acute hydrocephalus in nonketotic hyperglycinemia.

    abstract::We present four patients with typical neonatal onset non-ketotic hyperglycinemia (NKH) who developed hydrocephalus requiring shunting in early infancy. Brain imaging revealed acute hydrocephalus, a megacisterna magna or posterior fossa cyst, pronounced atrophy of the white matter, and an extremely thin corpus callosum...


    pub_type: 杂志文章


    authors: Van Hove JL,Kishnani PS,Demaerel P,Kahler SG,Miller C,Jaeken J,Rutledge SL

    更新日期:2000-02-08 00:00:00

  • Amino acid abnormalities in cerebrospinal fluid of patients with parkinsonism and extrapyramidal disorders.

    abstract::Free amino acid determinations in the cerebrospinal fluid of patients with Parkinson's disease or other extrapyramidal disorders showed that in both groups most amino acids were increased. Significantly increased amino acids were neutral and basic amino acids. Amino acid clusters were present and corresponded with the...


    pub_type: 杂志文章


    authors: Lakke JP,Teelken AW

    更新日期:1976-05-01 00:00:00

  • Proof of genetic heterogeneity in X-linked Charcot-Marie-Tooth disease.

    abstract:OBJECTIVE:To characterize a large family with X-linked Charcot-Marie-Tooth (CMT) neuropathy without mutations in the gap junction protein B1 (GJB1) gene, which has an unusual phenotype that is different in some aspects from classic CMTX1. METHODS:We tested CMT families consistent with X-linked inheritance for GJB1 mut...


    pub_type: 杂志文章


    authors: Huttner IG,Kennerson ML,Reddel SW,Radovanovic D,Nicholson GA

    更新日期:2006-12-12 00:00:00

  • Laryngeal botulinum toxin injections for disabling stuttering in adults.

    abstract::Stuttering is an action-induced speech disorder with involuntary, audible, or silent repetitions or prolongations in the utterance of short speech elements (sounds, syllables) and words. Symptomatic treatment programs frequently have initial success; persistent benefit is variable and many patients remain disabled. St...


    pub_type: 临床试验,杂志文章


    authors: Brin MF,Stewart C,Blitzer A,Diamond B

    更新日期:1994-12-01 00:00:00

  • Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease.

    abstract:BACKGROUND:Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system. The authors performed MRS to characterize metabolic alterations and their regional variation in brain tissue in GLD in vivo. METHODS:Abnormalities of cerebral ...


    pub_type: 临床试验,杂志文章


    authors: Brockmann K,Dechent P,Wilken B,Rusch O,Frahm J,Hanefeld F

    更新日期:2003-03-11 00:00:00

  • Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later.

    abstract:OBJECTIVES:We compared the ability of molecular biomarkers for Alzheimer disease (AD), including amyloid imaging and CSF biomarkers (Aβ42, tau, ptau181, tau/Aβ42, ptau181/Aβ42), to predict time to incident cognitive impairment among cognitively normal adults aged 45 to 88 years and followed for up to 7.5 years. METHOD...


    pub_type: 杂志文章


    authors: Roe CM,Fagan AM,Grant EA,Hassenstab J,Moulder KL,Maue Dreyfus D,Sutphen CL,Benzinger TL,Mintun MA,Holtzman DM,Morris JC

    更新日期:2013-05-07 00:00:00

  • Cognitive training in Parkinson disease: A systematic review and meta-analysis.

    abstract:OBJECTIVE:To quantify the effects of cognitive training (CT) on cognitive and behavioral outcome measures in patients with Parkinson disease (PD). METHODS:We systematically searched 5 databases for randomized controlled trials (RCTs) of CT in patients with PD reporting cognitive or behavioral outcomes. Efficacy was me...


    pub_type: 杂志文章,meta分析,评审


    authors: Leung IH,Walton CC,Hallock H,Lewis SJ,Valenzuela M,Lampit A

    更新日期:2015-11-24 00:00:00

  • Mortality in epilepsy: driving fatalities vs other causes of death in patients with epilepsy.

    abstract:OBJECTIVES:To estimate the risk to public safety posed by drivers with epilepsy, the authors compared annual totals and disease-specific risk for fatal crashes associated with seizures and other medical conditions. They compared individual risks for fatal crashes due to seizures and other causes of mortality in patient...


    pub_type: 杂志文章


    authors: Sheth SG,Krauss G,Krumholz A,Li G

    更新日期:2004-09-28 00:00:00

  • Leukoencephalopathy induced by levamisole alone for the treatment of recurrent aphthous ulcers.

    abstract::We report imaging and clinical findings of leukoencephalopathy occurring after levamisole. The lesions were hypoattenuating on CT and appeared as multifocal oval or elliptical foci in the white matter or along the subependymal veins on MRI. Most lesions resolve after prompt withdrawal of levamisole. Detailed history t...


    pub_type: 杂志文章


    authors: Liu HM,Hsieh WJ,Yang CC,Wu VC,Wu KD

    更新日期:2006-09-26 00:00:00

  • Hypotensive akathisia: autonomic failure associated with leg fidgeting while sitting.

    abstract::The author describes a distinct clinical syndrome in six patients with autonomic failure who manifested habitual, voluntary, transiently suppressible, yet irresistible leg movements occurring only in the sitting position. Keeping the legs still brought on vague symptoms of fatigue, lightheadedness, or apprehension. Re...


    pub_type: 杂志文章


    authors: Cheshire WP Jr

    更新日期:2000-12-26 00:00:00

  • Depressive symptoms and white matter dysfunction in retired NFL players with concussion history.

    abstract:OBJECTIVE:To determine whether correlates of white matter integrity can provide general as well as specific insight into the chronic effects of head injury coupled with depression symptom expression in professional football players. METHOD:We studied 26 retired National Football League (NFL) athletes who underwent dif...


    pub_type: 杂志文章


    authors: Strain J,Didehbani N,Cullum CM,Mansinghani S,Conover H,Kraut MA,Hart J Jr,Womack KB

    更新日期:2013-07-02 00:00:00

  • Phenotypic features of familial febrile seizures: case-control study.

    abstract:OBJECTIVE:To identify phenotypic features of febrile seizures that can be used to reduce heterogeneity and thereby increase power in linkage analysis. BACKGROUND:Despite exciting discoveries in several rare pedigrees, the genetic basis of common febrile seizures remains a mystery. The major drawback of studying common...


    pub_type: 杂志文章


    authors: Pal DK,Kugler SL,Mandelbaum DE,Durner M

    更新日期:2003-02-11 00:00:00

  • A competency-based longitudinal core curriculum in medical neuroscience.

    abstract::Current medical educational theory encourages the development of competency-based curricula. The Accreditation Council for Graduate Medical Education's 6 core competencies for resident education (medical knowledge, patient care, professionalism, interpersonal and communication skills, practice-based learning, and syst...


    pub_type: 杂志文章


    authors: Merlin LR,Horak HA,Milligan TA,Kraakevik JA,Ali II

    更新日期:2014-07-29 00:00:00

  • Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial.

    abstract:OBJECTIVE:To study the efficacy and safety of low-dose oral tetrahydrocannabinol (THC) in the treatment of dementia-related neuropsychiatric symptoms (NPS). METHODS:This is a randomized, double-blind, placebo-controlled study. Patients with dementia and clinically relevant NPS were randomly assigned to receive THC 1.5...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: van den Elsen GA,Ahmed AI,Verkes RJ,Kramers C,Feuth T,Rosenberg PB,van der Marck MA,Olde Rikkert MG

    更新日期:2015-06-09 00:00:00

  • Attentional distractibility by optokinetic stimulation in Alzheimer disease.

    abstract:OBJECTIVE:Unilateral temporoparietal injury may result in an attentional deficit for stimuli presented in contralesional space. Thus, bilateral temporoparietal degeneration associated with Alzheimer disease (AD) might result in a bilateral attentional disturbance. Tests for hemispatial neglect, however, primarily asses...


    pub_type: 杂志文章


    authors: Kim EJ,Lee BH,Seo SW,Moon SY,Jung DS,Park KH,Heilman KM,Na DL

    更新日期:2007-09-11 00:00:00

  • Rapsyn mutations in hereditary myasthenia: distinct early- and late-onset phenotypes.

    abstract::Rapsyn mutations in 16 unrelated patients with a congenital/hereditary myasthenic syndrome were identified, and a mutation (N88K) common to each of them was found. Two distinct phenotypes were noted: early and late onset. The former is frequently associated with arthrogryposis multiplex congenita and life-threatening ...


    pub_type: 杂志文章


    authors: Burke G,Cossins J,Maxwell S,Owens G,Vincent A,Robb S,Nicolle M,Hilton-Jones D,Newsom-Davis J,Palace J,Beeson D

    更新日期:2003-09-23 00:00:00

  • Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy.

    abstract:OBJECTIVES:We used functional MRI (fMRI), transcranial Doppler ultrasound, and visual evoked potentials (VEPs) to determine the nature of blood flow responses to functional brain activity and carbon dioxide (CO2) inhalation in patients with cerebral amyloid angiopathy (CAA), and their association with markers of CAA se...


    pub_type: 杂志文章


    authors: Peca S,McCreary CR,Donaldson E,Kumarpillai G,Shobha N,Sanchez K,Charlton A,Steinback CD,Beaudin AE,Flück D,Pillay N,Fick GH,Poulin MJ,Frayne R,Goodyear BG,Smith EE

    更新日期:2013-11-05 00:00:00

  • Non-neoplastic pineal cysts.

    abstract::We identified 53 patients with non-neoplastic cysts of the pineal gland. In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. ...


    pub_type: 杂志文章


    authors: Fetell MR,Bruce JN,Burke AM,Cross DT,Torres RA,Powers JM,Stein BM

    更新日期:1991-07-01 00:00:00

  • Hyperzincemia in anencephaly and spina bifida: a clue to the pathogenesis of neural tube defects?

    abstract::Zinc is essential for normal embryogenesis and may have particular importance for closure of the human neural tube. Compared to 258 controls, we found increased zinc content in umbilical cord serum in eight of nine newborn anencephalics (p less than 0.02) and three infants with spina bifida (p less than 0.001). Increa...


    pub_type: 杂志文章


    authors: Zimmerman AW

    更新日期:1984-04-01 00:00:00

  • Development and validation of a simplified Stroke-Thrombolytic Predictive Instrument.

    abstract:OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...


    pub_type: 杂志文章


    authors: Kent DM,Ruthazer R,Decker C,Jones PG,Saver JL,Bluhmki E,Spertus JA

    更新日期:2015-09-15 00:00:00

  • APOE epsilon4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy.

    abstract::The presence of an APOE epsilon4 allele may be a risk factor for neuropathy severity in diabetes. The authors assessed the frequency of APOE epsilon4 in patients presenting with sensory predominant neuropathy. APOE epsilon4 frequency among patients with early diabetic neuropathy and impaired glucose tolerance-associat...


    pub_type: 杂志文章


    authors: Zhou Z,Hoke A,Cornblath DR,Griffin JW,Polydefkis M

    更新日期:2005-01-11 00:00:00

  • Invited article: changing concepts in Parkinson disease: moving beyond the decade of the brain.

    abstract::Recent years have seen major changes in our understanding of Parkinson disease (PD), challenging conventional wisdom, much of which was established during the Decade of the Brain. In this article, we highlight important changes in our understanding of PD in six general categories: definition, etiology, pathology, path...


    pub_type: 杂志文章,评审


    authors: Marras C,Lang A

    更新日期:2008-05-20 00:00:00

  • Multiple sclerosis and age at exposure to childhood diseases and animals: cases and their friends.

    abstract::Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...


    pub_type: 杂志文章


    authors: Sullivan CB,Visscher BR,Detels R

    更新日期:1984-09-01 00:00:00

  • Relationship of motor symptoms to intellectual deficits in Parkinson disease.

    abstract::We studied 60 patients with idiopathic Parkinson disease with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficity. Significant correlations were found between the severity of brady kinesia and impaired performance on tests ass...


    pub_type: 杂志文章


    authors: Mortimer JA,Pirozzolo FJ,Hansch EC,Webster DD

    更新日期:1982-02-01 00:00:00

  • Clinical aspects of motor fluctuations in Parkinson's disease.

    abstract::Fluctuations in motor response eventually affect most patients with Parkinson's disease who have been exposed to chronic, intermittent levodopa administration for longer than 5 years. Response oscillations are often related to the timing of levodopa doses (predictable "wearing-off"), but random "on-off" effects also o...


    pub_type: 杂志文章,评审


    authors: Poewe WH

    更新日期:1994-07-01 00:00:00

  • Levodopa, melanoma, and Parkinson's disease.

    abstract::Previous reports and the Physicians' Desk Reference caution against the use of levodopa in Parkinson's disease (PD) patients with melanoma. A critical review of the literature reveals only anecdotal evidence to support a link between levodopa and melanoma. In fact, levodopa has an antitumor effect on melanoma. We repo...


    pub_type: 杂志文章,评审


    authors: Weiner WJ,Singer C,Sanchez-Ramos JR,Goldenberg JN

    更新日期:1993-04-01 00:00:00

  • Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography.

    abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...


    pub_type: 杂志文章


    authors: Kishore A,Nygaard TG,de la Fuente-Fernandez R,Naini AB,Schulzer M,Mak E,Ruth TJ,Calne DB,Snow BJ,Stoessl AJ

    更新日期:1998-04-01 00:00:00

  • Cerebrovascular ischemic events in wind instrument players.

    abstract::Two cases of ischemic stroke due to carotid artery dissection occurring during wind instrument playing, probably caused by increased intrathoracic and subsequent intrapharyngeal pressure, are presented. A review of the literature revealed three similar patients with other types of cerebrovascular events, such as parad...


    pub_type: 杂志文章


    authors: Evers S,Altenmüller E,Ringelstein EB

    更新日期:2000-09-26 00:00:00