Motor perseverative behavior on a line cancellation task.

abstract：OBJECTIVE:To assess pathologic changes in prospectively characterized subjects with essential tremor (ET). METHODS:Subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program were examined annually by a movement disorders neurologist, and semiannually by a behavioral neurologist and neuropsy...

journal_title：Neurology

authors： Shill HA,Adler CH,Sabbagh MN,Connor DJ,Caviness JN,Hentz JG,Beach TG

更新日期：2008-04-15 00:00:00

abstract：OBJECTIVE:To describe the phenotype and phenotype-genotype correlations in patients with amyotrophic lateral sclerosis (ALS) with TARDBP gene mutations. METHODS:French TARDBP+ patients with ALS (n = 28) were compared first to 3 cohorts: 737 sporadic ALS (SALS), 192 nonmutated familial ALS (FALS), and 58 SOD1 + FALS, a...

journal_title：Neurology

authors： Corcia P,Valdmanis P,Millecamps S,Lionnet C,Blasco H,Mouzat K,Daoud H,Belzil V,Morales R,Pageot N,Danel-Brunaud V,Vandenberghe N,Pradat PF,Couratier P,Salachas F,Lumbroso S,Rouleau GA,Meininger V,Camu W

更新日期：2012-05-08 00:00:00

abstract：:Recent years have seen major changes in our understanding of Parkinson disease (PD), challenging conventional wisdom, much of which was established during the Decade of the Brain. In this article, we highlight important changes in our understanding of PD in six general categories: definition, etiology, pathology, path...

journal_title：Neurology

authors： Marras C,Lang A

更新日期：2008-05-20 00:00:00

abstract：:A new cerebral disorder, described in three unrelated children, has recognizable clinical, radiologic, and neuropathologic findings. The onset occurs from early infancy to adolescence with slowing of cognitive performance, rare convulsive seizures, and a mixture of extrapyramidal, cerebellar, and pyramidal signs. CT s...

journal_title：Neurology

authors： Labrune P,Lacroix C,Goutières F,de Laveaucoupet J,Chevalier P,Zerah M,Husson B,Landrieu P

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:To study the effects of head injury on disease progression and on neuropathologic outcomes in amyotrophic lateral sclerosis (ALS). METHODS:Patients with ALS were surveyed to obtain head injury history, and medical records were reviewed. Linear regression was performed to determine if head injury was a predi...

journal_title：Neurology

authors： Fournier CN,Gearing M,Upadhyayula SR,Klein M,Glass JD

更新日期：2015-04-28 00:00:00

abstract：OBJECTIVE:To determine whether serum Zic4 antibodies associate with paraneoplastic neurologic disorders (PND) and small-cell lung cancer (SCLC), and the association of these antibodies with other onconeuronal immunities associated with SCLC. DESIGN/METHODS:The authors studied 498 patients (215 with PND and 283 without...

journal_title：Neurology

authors： Bataller L,Wade DF,Graus F,Stacey HD,Rosenfeld MR,Dalmau J

更新日期：2004-03-09 00:00:00

abstract：:We investigated the prevalence of Parkinson's disease and other types of parkinsonism in a Sicilian population using a door-to-door two-phase approach. This design called for the administration of a brief screening instrument to all subjects who, on November 1, 1987, were residents of Terrasini (Palermo Province), San...

journal_title：Neurology

authors： Morgante L,Rocca WA,Di Rosa AE,De Domenico P,Grigoletto F,Meneghini F,Reggio A,Savettieri G,Castiglione MG,Patti F

更新日期：1992-10-01 00:00:00

abstract：:Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy vo...

journal_title：Neurology

authors： Wang W,Timsit-Berthier M,Schoenen J

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To assess the attitudes, knowledge, and practice patterns of US neurologists regarding migraine management relative to the US Headache Consortium Guidelines (the Guidelines). METHODS:Two samples of 600 neurologists each were selected from the American Academy of Neurology membership database. The first group...

journal_title：Neurology

authors： Lipton RB,Bigal ME,Rush SR,Yenkosky JP,Liberman JN,Bartleson JD,Silberstein SD

更新日期：2004-06-08 00:00:00

abstract：OBJECTIVE:To critically re-evaluate cases diagnosed as adult neuronal ceroid lipofuscinosis (ANCL) in order to aid clinicopathologic diagnosis as a route to further gene discovery. METHODS:Through establishment of an international consortium we pooled 47 unsolved cases regarded by referring centers as ANCL. Clinical a...

journal_title：Neurology

authors： Berkovic SF,Staropoli JF,Carpenter S,Oliver KL,Kmoch S,Anderson GW,Damiano JA,Hildebrand MS,Sims KB,Cotman SL,Bahlo M,Smith KR,Cadieux-Dion M,Cossette P,Jedličková I,Přistoupilová A,Mole SE,ANCL Gene Discovery Consortiu

更新日期：2016-08-09 00:00:00

abstract：:Glucocorticoid therapy slows the progression of Duchenne muscular dystrophy. In muscle cultures, the addition of the glucocorticoid methylprednisolone increases myogenesis in most normal mixed and clonal cultures. Conversely, in some normal clonal and most dystrophic cultures, methylprednisolone inhibits fusion. Howev...

journal_title：Neurology

authors： Hardiman O,Sklar RM,Brown RH Jr

更新日期：1993-02-01 00:00:00

abstract：:We studied a family with an extrapyramidal disorder characterized by childhood onset of lower-limb and axial dystonia, followed by parkinsonism. Dramatic response to levodopa therapy and minimal progression in adult life was seen. The family included five generations of affected members of both sexes in an autosomal d...

journal_title：Neurology

authors： Nygaard TG,Duvoisin RC

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:A European (EU) and a North American (NA) placebo-controlled study with interferon beta-1b (IFNB-1b) in secondary progressive multiple sclerosis (SPMS) showed divergent results with regard to their primary outcome of sustained Expanded Disability Status Scale (EDSS) progression, while effects were similar on...

journal_title：Neurology

authors： Kappos L,Weinshenker B,Pozzilli C,Thompson AJ,Dahlke F,Beckmann K,Polman C,McFarland H,European (EU-SPMS) Interferon beta-1b in Secondary Progressive Multiple Sclerosis Trial Steering Committee and Independent Advisory Board.,North Ame

更新日期：2004-11-23 00:00:00

abstract：:We retrospectively examined the clinical courses of 20 children with severe near-drowning and divided their outcomes into 3 groups: normal (4), persistent vegetative state (9), and dead (7). We reviewed serial blood glucose levels and cerebral blood flow measured by stable xenon computed tomography within the 1st 48 h...

journal_title：Neurology

authors： Ashwal S,Schneider S,Tomasi L,Thompson J

更新日期：1990-05-01 00:00:00

abstract：:Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...

journal_title：Neurology

authors： Rosenblum WI

更新日期：1975-12-01 00:00:00

abstract：:A 78-year-old woman presented with a right basal ganglia infarct 6 weeks after a left herpes zoster ophthalmicus. MR angiography showed focal segmental stenosis of the proximal segments of the anterior, middle, and posterior cerebral arteries. Varicella DNA was detected in the CSF by polymerase chain reaction (PCR). T...

journal_title：Neurology

authors： Melanson M,Chalk C,Georgevich L,Fett K,Lapierre Y,Duong H,Richardson J,Marineau C,Rouleau GA

更新日期：1996-08-01 00:00:00

abstract：:Intracranial EEG recording is often required to identify an area of the brain for resective surgery for intractable epilepsy. We simultaneously compared bilaterally placed depth and limited subdural electrode EEG to determine the most effective method of recording seizures from the temporal lobes. Localized complex pa...

journal_title：Neurology

authors： Sperling MR,O'Connor MJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal. METHODS:The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evi...

journal_title：Neurology

authors： Helmchen C,Rambold H,Kempermann U,Büttner-Ennever JA,Büttner U

更新日期：2002-12-24 00:00:00

abstract：:Antiacetylcholine receptor antibody (anti-AChR) was spontaneously synthesized by cultured thymic tissue from 19 of 35 patients with myasthenia gravis. Two other thymus cultures produced antibody after stimulation by pokeweed mitogen. Antibody production correlated with histologic evidence of thymitis, long duration of...

journal_title：Neurology

authors： Scadding GK,Vincent A,Newsom-Davis J,Henry K

更新日期：1981-08-01 00:00:00

abstract：OBJECTIVE:To clarify the possible relation between the extent of involvement of catecholaminergic neurons and the presence of alveolar hypoventilation in patients with myotonic dystrophy (MyD). BACKGROUND:Respiratory insufficiency has been reported frequently in MyD patients. Recent data support the hypothesis that th...

journal_title：Neurology

authors： Ono S,Takahashi K,Jinnai K,Kanda F,Fukuoka Y,Kurisaki H,Mitake S,Inagaki T,Yamano T,Shimizu N,Nagao K

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To determine whether blood-based biomarkers can differentiate older veterans with and without traumatic brain injury (TBI) and cognitive impairment (CogI). METHODS:We enrolled 155 veterans from 2 veterans' retirement homes: 90 without TBI and 65 with TBI history. Participants were further separated into CogI...

journal_title：Neurology

authors： Peltz CB,Kenney K,Gill J,Diaz-Arrastia R,Gardner RC,Yaffe K

更新日期：2020-09-01 00:00:00

abstract：:Although people with migraine are aware of their headaches they are often not aware that they have migraine. This can lead to inappropriate or ineffective use of treatments, delays in seeking appropriate care, and miscommunication during clinical encounters. This article assesses self-recognition of migraine and ident...

journal_title：Neurology

authors： Lipton RB,Stewart WF,Liberman JN

更新日期：2002-05-14 00:00:00

abstract：OBJECTIVE:To examine the relationship between carotid artery stenosis, other risk factors, and lacunar stroke. BACKGROUND:Carotid artery stenosis in patients presenting with lacune stroke may be coincidental or causal. The distinction by risk factor profile is uncertain. The risk and cause of subsequent stroke, and be...

journal_title：Neurology

authors： Inzitari D,Eliasziw M,Sharpe BL,Fox AJ,Barnett HJ

更新日期：2000-02-08 00:00:00

abstract：:Restless legs syndrome (RLS) is characterized by an urge to move the legs. The symptoms are more intense in the evening and during periods of inactivity. RLS symptoms are relieved by movement. It is classified as a sleep disorder, but in many ways it is actually a disorder of wakefulness that seems to intrude upon the...

journal_title：Neurology

authors： Auerbach S,Walters AS

更新日期：2014-04-08 00:00:00

abstract：OBJECTIVE:To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy. METHODS:As proof of principle, 22 patients with well-compensated, biopsy-proven cirrhosis of differing etiology and previous minimal hepat...

journal_title：Neurology

authors： McPhail MJ,Leech R,Grover VP,Fitzpatrick JA,Dhanjal NS,Crossey MM,Pflugrad H,Saxby BK,Wesnes K,Dresner MA,Waldman AD,Thomas HC,Taylor-Robinson SD

更新日期：2013-03-12 00:00:00

abstract：:Pergolide, a long-acting central dopamine agonist, was used as monotherapy in 16 parkinsonian patients. A mean daily dose of 6.3 mg resulted in 73% improvement of parkinsonian disability. Clinical improvement after acute administration of one dose of pergolide was similar to that observed after levodopa plus a periphe...

journal_title：Neurology

authors： Mear JY,Barroche G,de Smet Y,Weber M,Lhermitte F,Agid Y

更新日期：1984-07-01 00:00:00

abstract：:Subacute necrotizing encephalopathy (SNE) or Leigh's disease is associated with various defects in oxidative phosphorylation (OXPHOS). However, the relationships between these OXPHOS defects and nuclear DNA or mitochondrial DNA (mtDNA) mutations is still unclear. We evaluated three SNE pedigrees (two singleton cases a...

journal_title：Neurology

authors： Shoffner JM,Fernhoff PM,Krawiecki NS,Caplan DB,Holt PJ,Koontz DA,Takei Y,Newman NJ,Ortiz RG,Polak M

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). METHODS:Forty-nine patients with PD and 54 age-matched controls were analyzed. Ophthalmologic examination and macula optical coherence tomography scans were performed with additional microperi...

journal_title：Neurology

authors： Ahn J,Lee JY,Kim TW,Yoon EJ,Oh S,Kim YK,Kim JM,Woo SJ,Kim KW,Jeon B

更新日期：2018-09-11 00:00:00

abstract：:The authors estimated the sample sizes needed for exploratory trials of MS assessing the efficacy of new treatments in reducing the number of new enhancing lesions vs those of interferon-beta or glatiramer acetate. The sample sizes per arm ranged from 868 (effect: 20%) to 94 (effect: 50%) for patients with relapsing-r...

journal_title：Neurology

authors： Sormani MP,Rovaris M,Bagnato F,Molyneux P,Bruzzi P,Pozzilli C,Miller DH,Comi G,Filippi M

更新日期：2001-11-27 00:00:00

abstract：OBJECTIVE:To examine the genetic relationships among epilepsies with different seizure types--myoclonic, absence, and generalized tonic-clonic--within the idiopathic generalized epilepsies (IGEs). BACKGROUND:Careful phenotype definition in the epilepsies may allow division into groups that share susceptibility genes. ...

journal_title：Neurology

authors： Winawer MR,Marini C,Grinton BE,Rabinowitz D,Berkovic SF,Scheffer IE,Ottman R

更新日期：2005-08-23 00:00:00