Abstract:
OBJECTIVE:To empirically validate the expanded concept of mild cognitive impairment (MCI), which differentiates between four clinical subtypes-amnestic MCI-single domain, amnestic MCI-multiple domains, nonamnestic MCI-single domain, and nonamnestic MCI-multiple domains-and to examine the prevalence, course, and outcome of these four clinical MCI subtypes. METHODS:We studied a community sample of 980 dementia-free individuals aged 75 years or older who participated in the Leipzig Longitudinal Study of the Aged (LEILA 75+). All participants were examined by neuropsychological testing based on 6 years of observation. The diagnoses of the four clinical MCI subtypes were made according to the original and to slightly modified criteria by Petersen et al. (2001) (both with a cutoff of 1.0 SD and with a cutoff of 1.5 SD). The complete range of outcome types (dementia, death, improvement, stable diagnosis, unstable diagnosis) was described for all subtypes. The relative predictive power of stable MCI for dementia onset was determined. RESULTS:MCI-single domain is more frequent than MCI-multiple domains, and the nonamnestic MCI type is as frequent as the amnestic MCI type. The "MCI modified, 1.0 SD" criteria have the highest relative predictive power for the development of dementia (sensitivity = 74%, specificity = 73%). Alzheimer disease (AD) was the most common type of dementia at follow-up in all but one MCI subtype. Participants with nonamnestic MCI-multiple domains were more likely to progress to a non-AD dementia. CONCLUSIONS:It has been assumed that each MCI subtype is associated with an increased risk for a particular type of dementia. We can only partially agree with this.
journal_name
Neurologyjournal_title
Neurologyauthors
Busse A,Hensel A,Gühne U,Angermeyer MC,Riedel-Heller SGdoi
10.1212/01.wnl.0000249117.23318.e1subject
Has Abstractpub_date
2006-12-26 00:00:00pages
2176-85issue
12eissn
0028-3878issn
1526-632Xpii
67/12/2176journal_volume
67pub_type
杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To compare effects of immediate-release (IR) and sustained-release (CR) carbidopa/levodopa in levodopa-naive PD patients. BACKGROUND:It was hypothesized that the long-acting preparation would be associated with fewer long-term complications. METHODS:A total of 618 patients were studied in 36 centers worldwi...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.53.5.1012
更新日期:1999-09-22 00:00:00
abstract::In an attempt to determine the opinions and practices of neurologists regarding the use of antithrombotic drugs in the treatment of acute ischemic stroke, we conducted a survey of 349 randomly selected neurologists from throughout the United States. Responses were received from 247 (71%), and 219 identified themselves...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.12.1631
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To explore an association with survival of modifying the current standard of care for patients with newly diagnosed glioblastoma of surgery followed by radiotherapy plus concurrent and 6 cycles of maintenance temozolomide chemotherapy (TMZ/RT → TMZ) by extending TMZ beyond 6 cycles. METHODS:The German Glioma...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003809
更新日期:2017-04-11 00:00:00
abstract::We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD). One hundred twelve subjects were included in the study. Of thes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1148
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Frontotemporal dementia associated with motor neuron disease (FTD-MND) is a rare neurodegenerative disorder that may be inherited by autosomal dominant trait. No major gene has been identified but a locus was mapped on chromosome 9 (9p21.3-p13.3). METHODS:Ten French families with FTD-MND were tested for lin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181a55f1c
更新日期:2009-05-12 00:00:00
abstract:OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000160000.01742.9D
更新日期:2005-05-10 00:00:00
abstract:OBJECTIVE:Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. METHODS:Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001702
更新日期:2015-07-07 00:00:00
abstract:OBJECTIVE:To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an upgoing thumb sign. METHODS:We previously reported an upgoing thumb sign as a subtle clinical finding in patients with tran...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004157
更新日期:2017-07-25 00:00:00
abstract::Seizures are not expected in progressive multifocal leukoencephalopathy (PML), a condition considered to be restricted to the white matter. Review of medical records of 89 patients with possible or proven PML showed an 18% prevalence of seizures. Seizures usually responded well to treatment and did not affect survival...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000194227.16696.11
更新日期:2006-01-24 00:00:00
abstract::Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1257
更新日期:2002-10-22 00:00:00
abstract::We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.253
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:To assess hearing in patients with essential tremor (ET) vs patients with Parkinson disease (PD) and normal controls. METHODS:The authors assessed demographic and clinical information including use of hearing aids in 250 patients with ET, 127 patients with PD, and 127 normal controls. The authors administere...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000086376.40750.af
更新日期:2003-10-28 00:00:00
abstract:OBJECTIVE:To investigate whether the presence of cerebral microbleeds, which present as focal lesions on imaging, is associated with a diffuse loss of white matter microstructural integrity in the brain. METHODS:In the prospective, population-based Rotterdam Scan Study, a total of 4,493 participants underwent brain MR...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436609.20587.65
更新日期:2013-11-26 00:00:00
abstract:BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.5.663
更新日期:2000-09-12 00:00:00
abstract::The authors report two cases of patients with word deafness. The word deafness occurred after a head injury for the first patient and after an arterio venous malformation embolization for the second patient. MRI demonstrated bilateral lesions of the inferior colliculi but brainstem auditory-evoked potentials (BAEP) we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.6.970
更新日期:2002-03-26 00:00:00
abstract::We tested three serotonin antagonists--lysergic acid diethylamide (LSD), 2-bromolysergic acid diethylamide (BOL), and cinanserin--for effects on experimental spinal cord ischemia in the rabbit. Blood flow to spinal cord was obstructed. Drugs were administered before or after initiation of occlusion, and flow was later...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.4.469
更新日期:1984-04-01 00:00:00
abstract::We treated 36 patients with motor fluctuations and dyskinesias on chronic levodopa therapy with cabergoline (CBG) once a day for a mean period of 14.2 +/- 5.8 months. There was a significant increase in the "on" hours and a reduction in "off-period" dystonia. Ten patients continued to show a marked improvement after 2...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2587
更新日期:1993-12-01 00:00:00
abstract::Cisternography and ventriculography were performed in five normal anesthetized dogs to study the dynamics of tracer dispersal. Indium 111-diethylenetriaminepentaacetic acid was injected into lateral ventricles, cisterna magna, thoracic subarachnoid space, and lumbar sac. The patterns of dispersal from each injection s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.3.254
更新日期:1976-03-01 00:00:00
abstract::A 11-year-old boy of short stature had recurrent right temporal pounding headaches of 7 months' duration, and progressive visual loss for 3 days. There was a left hemianopia, alexia without agraphia, and diffuse muscle weakness. Investigation established the presence of a mitochondrial myopathy with pyruvate and lacti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.5.717
更新日期:1979-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.10.1763
更新日期:2001-11-27 00:00:00
abstract::The authors describe two patients with clinical manifestations of the osmotic demyelination syndrome (ODS) and unusual MRI findings of gadolinium-enhancing peripheral cortical abnormalities. They propose that these represent extrapontine manifestations of ODS because neither patient had a notable hypoxic-ischemic insu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.7.1048
更新日期:2000-10-10 00:00:00
abstract:OBJECTIVE:To determine the incidence of first seizures, epilepsy, and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition, which allows an epilepsy diagnosis after a single seizure when the risk of further seizures over the next 10 years is ≈60%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009980
更新日期:2020-08-04 00:00:00
abstract::Long-term hypothalamic stimulation is effective in improving drug-resistant chronic cluster headache (CH). We assessed acute hypothalamic stimulation to resolve ongoing CH attacks in 16 patients implanted to prevent chronic CH, investigating 136 attacks. A pain intensity reduction of > or =50% occurred in 25 of 108 ev...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000247273.93084.49
更新日期:2006-11-28 00:00:00
abstract:OBJECTIVE:To demonstrate whether the cerebral hemispheres (language dominant versus nondominant) affect immune function differentially in humans by delineating the effects of resections for epilepsy surgery on T-cell indices. BACKGROUND:Cerebral lateralization has been postulated to affect immunomodulation. Differenti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.6.1183
更新日期:1999-04-12 00:00:00
abstract:OBJECTIVE:We performed a longitudinal cohort study of infants with tuberous sclerosis complex (TSC), with the overarching goal of defining early clinical, behavioral, and biological markers of autism spectrum disorder (ASD) in this high-risk population. METHODS:Infants with TSC and typically developing controls were r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000568
更新日期:2014-07-08 00:00:00
abstract:BACKGROUND:Recent studies demonstrated an excess of winter births in children with brain tumors and in adults with various neurologic or psychiatric diseases relative to the general population. OBJECTIVE:To investigate a possible association between month of birth and risk of brain tumors in adults using data from a l...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000129984.01327.9d
更新日期:2004-07-27 00:00:00
abstract:OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182582fe7
更新日期:2012-05-29 00:00:00
abstract::Autonomic functions were studied after withdrawal of all medication in parkinsonian out-patients with short and long duration of disease and in age-matched healthy control subjects. Vagal heart control and noradrenergic response to standing were impaired and related to duration of symptoms of idiopathic parkinsonism. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.7.1173
更新日期:1987-07-01 00:00:00
abstract::We developed a scheme using routinely available data to estimate the risk of human immunodeficiency virus (HIV) dementia in HIV-infected persons over time. We performed a longitudinal review of medical records from more than 100 medical facilities in 11 U.S. cities. A total of 19,462 HIV-infected persons without histo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.392
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective study was to survey our patients about their experience with our clinic's telemedicine program to better understand telemedicine's utility for families, and to improve patient satisfaction and ultimately patient care. METHODS:This was a prospective survey study of patients and the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005482
更新日期:2018-05-08 00:00:00