Abstract:
:We investigated tyrosine-hydroxylase (TH)-immunoreactive neurons in the medulla oblongata corresponding to the A1 and A2 cell groups in autopsy tissue of patients with Parkinson's disease (PD) (n = 3), progressive supranuclear palsy (PSP) (n = 3), striatonigral degeneration (SND) (n = 2), and in controls (n = 4). The estimated total number of TH-positive neurons in the A1 and the A2 regions was normal in PD and PSP patients. The sparing of medullary catecholaminergic cells in PD and PSP may be related to their minor degree of melanization and the possibility that intermediate compounds associated with the oxidative catabolism of norepinephrine and epinephrine may be less cytotoxic than those generated by degradation of dopamine. Patients with SND showed a marked loss of TH-immunoreactive cells in the A1 and the A2 groups, which may contribute to the impairment of vasomotor control characteristic of the disease.
journal_name
Neurologyjournal_title
Neurologyauthors
Malessa S,Hirsch EC,Cervera P,Duyckaerts C,Agid Ydoi
10.1212/wnl.40.11.1739subject
Has Abstractpub_date
1990-11-01 00:00:00pages
1739-43issue
11eissn
0028-3878issn
1526-632Xjournal_volume
40pub_type
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