Abstract:
:The blink reflex may be evoked by auditory click or light stimulation, the latter being constantly present in all healthy subjects. The latency and amplitude of the light-stimulus-evoked blink response (L-BR) is influenced by the light intensity, distance between the light stimulus and the eye, attention, and background facilitation. The L-BR was abnormal in 75% of definite and 61% of probable multiple sclerosis (MS) patients. When abnormal, the L-BR was more commonly absent than delayed. Optic nerve lesions could be identified by the pattern of abnormalities in the L-BR in some patients. The L-BR has proved to be a sensitive detector of abnormalities in the visual connections and, in combination with the Vth nerve stimulation-evoked blink response, a valuable detector of brainstem lesions.
journal_name
Neurologyjournal_title
Neurologyauthors
Yates SK,Brown WFdoi
10.1212/wnl.31.3.272subject
Has Abstractpub_date
1981-03-01 00:00:00pages
272-81issue
3eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.879
更新日期:1999-03-10 00:00:00
abstract::Using (18)F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.10.1575
更新日期:2000-11-28 00:00:00
abstract:OBJECTIVE:To characterize brain functional connectivity in subjects with prechiasmatic visual system damage and relate functional connectivity features to extent of vision loss. METHODS:In this case-control study, resting-state, eyes-closed EEG activity was recorded in patients with partial optic nerve damage (n = 15)...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000672
更新日期:2014-08-05 00:00:00
abstract::A 33-year-old man with untreated hypertension had sudden onset of signs and symptoms suggestive of a dorsal lateral medullary syndrome. He died after 27 days. Postmortem studies revealed intramedullary hemorrhage with extension into the fourth ventricle and hypertensive cardiovascular disease. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.925
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:The authors previously reported on the development of thyroid dysfunction and autoimmunity during 1-year treatment of patients with MS with interferon-beta 1b (IFN beta-1b). OBJECTIVE:To evaluate the evolution of incident thyroid disease and the possible development of more thyroid disease during longer ter...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.55.4.549
更新日期:2000-08-22 00:00:00
abstract::A 3-year 8-month-old girl died after 14 months of illness characterized by episodes of intermittent ataxia associated with oculomotor palsy, hypotonia, mental confusion, and disturbances of consciousness. In the last 4 months of life, there were signs of liver dysfunction. Pyruvate dehydrogenase and alpha-ketoglutarat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1578
更新日期:1979-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000318294.36223.69
更新日期:2008-08-19 00:00:00
abstract:OBJECTIVE:To investigate the role of blocking antibodies in neonatal Guillain-Barré syndrome (GBS) occurring 12 days postpartum in a child born to a mother with ongoing GBS. METHODS:We studied plasma filtrate, purified IgG, and monovalent Fab fragments from the affected mother and serum from the neonate as well as ser...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.6.1246
更新日期:1999-10-12 00:00:00
abstract::A wide variety of movement disorders are associated with alcohol abuse. Some idiopathic movement disorders are markedly improved by small amounts of alcohol and this response occasionally may lead to alcoholism. Alcohol abuse alone or combined with hepatic encephalopathy can cause various types of tremor, asterixis, a...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.40.5.741
更新日期:1990-05-01 00:00:00
abstract::We compared the electrodiagnostic studies of 40 patients with chronic acquired demyelinative neuropathy and 18 patients with familial demyelinative neuropathy. Patients with acquired neuropathy had differential slowing of conduction velocity when distal latencies were compared with more proximal conduction velocities ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.6.592
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Computerized ambulatory monitoring provides real-time assessments of clinical outcomes in natural contexts, and it has been increasingly applied in recent years to investigate symptom expression in a wide range of disorders. The purpose of this study was to examine the feasibility and validity of this data c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c0d466
更新日期:2009-11-10 00:00:00
abstract::We reviewed 44 cases of ischemia and infarction of the spinal cord at two university hospitals. Three patients experienced transient ischemic attacks. Etiologies of completed strokes were diverse and included rupture and surgical repair of aortic aneurysms, aortic dissection, aortic rupture and thrombosis, global isch...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.2.321
更新日期:1996-08-01 00:00:00
abstract::Family studies of primary torsion dystonia have used the diagnostic categories of definite, probable, and possible dystonia for gene mapping and identification, but the validity of this hierarchical classification is not known. The authors assessed 147 DYT1 GAG deletion carriers and 113 blood-related noncarriers from ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000035630.12515.e0
更新日期:2002-12-10 00:00:00
abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.885
更新日期:1998-09-01 00:00:00
abstract::We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.5.1469
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000160000.01742.9D
更新日期:2005-05-10 00:00:00
abstract::Previous anatomic and physiologic studies suggest brainstem dysfunction in cranial-cervical dystonia. To further explore this, we studied suprathreshold acoustic reflex waveforms in 15 such patients. A unique feature of this technique is its ability to reject movement artifacts before averaging the acoustic reflex wav...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.594
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and predictors of acute cerebral ischemia and neurologic deterioration in intracerebral hemorrhage (ICH) patients after an institutional protocol change in systolic blood pressure (SBP) target from <160 to <140 mm Hg. METHODS:We retrospectively compared persons admitted with primar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006156
更新日期:2018-09-11 00:00:00
abstract:OBJECTIVE:The Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society develop practice parameters as strategies for patient management based on analysis of evidence. For this parameter, the authors reviewed available evidence on the evaluation of the...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引
doi:10.1212/wnl.59.4.490
更新日期:2002-08-27 00:00:00
abstract::Six patients with Parkinson's disease, six patients with essential or intention tremor, and nine controls were tested on a step-tracking task using a joystick control and oscilloscope display. Tremor subjects resembled controls in making an initial ballistic movement followed by (defective) corrections, and took longe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.5.413
更新日期:1975-05-01 00:00:00
abstract:OBJECTIVE:To evaluate an observational-behavioral pain tool among individuals with acute poststroke aphasia. METHODS:We performed a randomized, double-blind, controlled study of experimental pain assessment among 36 adult patients with acute poststroke aphasia. Patients were administered 3 levels of mechanical pain, i...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000006081
更新日期:2018-08-28 00:00:00
abstract::Mapping eloquent language cortex in presurgical patients typically is accomplished using highly invasive direct cortical stimulation techniques. Functional imaging during language activation using positron emission tomography (PET) is a promising, noninvasive alternative that requires validation. In seven patients und...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.4.1056
更新日期:1997-04-01 00:00:00
abstract::Dr. Masur and colleagues(1) from the Childhood Absence Epilepsy Study Group tried to answer a few important questions regarding childhood absence epilepsy (CAE) in their article "Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy." First, they wanted to know whether childr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436060.67147.25
更新日期:2013-10-29 00:00:00
abstract::Stuttering is an action-induced speech disorder with involuntary, audible, or silent repetitions or prolongations in the utterance of short speech elements (sounds, syllables) and words. Symptomatic treatment programs frequently have initial success; persistent benefit is variable and many patients remain disabled. St...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.44.12.2262
更新日期:1994-12-01 00:00:00
abstract::Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.614
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:To compare the degrees to which 8 domains of health are affected across types of cerebrovascular events and to identify factors associated with domain scores in different event types. METHODS:This was an observational cohort study of 2,181 patients with ischemic stroke, intracerebral hemorrhage (ICH), subar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006626
更新日期:2018-12-04 00:00:00
abstract:OBJECTIVE:The gradual development of cutaneous allodynia during the course of a migraine attack is commonly detected by quantitative sensory testing (QST) in migraineurs seeking secondary and tertiary medical help. In this study, the authors developed a questionnaire that tested the recollection of the patients on thei...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183358.53939.38
更新日期:2005-11-08 00:00:00
abstract::The authors describe two novel mutations of the acid alpha-glucosidase gene, P361L and R437C, which define the juvenile-onset glycogen storage disease type II (GSDII) in a 16-year-old Chinese patient. The asymptomatic 13-year-old brother of the proband is also a compound heterozygote of the two mutations. These result...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000048661.95327.bf
更新日期:2003-02-25 00:00:00
abstract::The long-term evolution of Hu antibody (Hu-Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu-Ab titers in 35 patients with PNS with a median follow-up of 32 months (range 6 to 108 months). No correlation was observed between Hu-Ab titers and neurologi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000144340.03364.bf
更新日期:2004-11-23 00:00:00
abstract:OBJECTIVE:Dominant, left anteromedial temporal lobe resection (AMTLR) for seizure control carries risks to verbal episodic memory and visual object naming. Consistent with traditional thinking, verbal memory decline is considered a consequence of hippocampal removal and naming decline has been attributed to lateral tem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181dd40f0
更新日期:2010-05-11 00:00:00