Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism.

Abstract:

:Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls the synthesis of nitric oxide, could possibly be a cause, or candidate gene, in migraine etiology. In this study, we detected a polymorphism for endothelial nitric oxide synthase by polymerase chain reaction and tested this for association and linkage to migraine. Results from the study did not show an association of the nitric oxide synthase microsatellite when tested in 91 affected and 85 unaffected individuals. Using the FASTLINK program for parametric linkage analysis, the polymorphism did not show significant linkage to migraine when tested in four migraine pedigrees composed of 116 individuals, 52 affected. Total LOD scores excluded linkage up to 8.5 cM between the nitric oxide synthase polymorphism and migraine. Results using the nonparametric affected pedigree member form of analysis also did not support a role for this gene in migraine etiology.

journal_name

Neurology

journal_title

Neurology

authors

Griffiths LR,Nyholt DR,Curtain RP,Goadsby PJ,Brimage PJ

doi

10.1212/wnl.49.2.614

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

614-7

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

49

pub_type

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