Abstract:
:We studied lymphocyte subsets and major histocompatibility complex (MHC) class II antigens in frozen brain tissues from three patients with subacute sclerosing panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs consisted predominantly of T cells and MHC class II-positive cells. In the parenchymal lesions, there were frequent B and CD4+ cells. MHC class II-positive cells were also diffusely distributed throughout the parenchyma. There were more CD4+ than CD8+ cells both in the parenchyma and in the perivascular cuffs. These findings suggest an overrepresentation of CD4+ cells in SSPE lesions and that CD4+ cells may be involved in the pathogenesis of SSPE.
journal_name
Neurologyjournal_title
Neurologyauthors
Nagano I,Nakamura S,Yoshioka M,Kogure Kdoi
10.1212/wnl.41.10.1639subject
Has Abstractpub_date
1991-10-01 00:00:00pages
1639-42issue
10eissn
0028-3878issn
1526-632Xjournal_volume
41pub_type
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