Abstract:
:A patient with PD who exhibited disabling tremor and prominent dyskinesia underwent deep brain stimulation (DBS) of the left thalamic ventral intermediate nucleus. The electrode migrated and was replaced but with suboptimal clinical response. Two years later, postmortem analysis found the second electrode tip had entered the thalamic centromedian-parafascicular complex. There was a small thalamotomy and cell loss exceeding that found in PD. Thalamic damage may occur in association with DBS for PD.
journal_name
Neurologyjournal_title
Neurologyauthors
Henderson JM,O'Sullivan DJ,Pell M,Fung VS,Hely MA,Morris JG,Halliday GMdoi
10.1212/wnl.56.11.1576subject
Has Abstractpub_date
2001-06-12 00:00:00pages
1576-9issue
11eissn
0028-3878issn
1526-632Xjournal_volume
56pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:INTRODUCTION:As clinical trials move toward earlier intervention, we sought to redefine the β-amyloid (Aβ)-PET threshold based on the lowest point in a baseline distribution that robustly predicts future Aβ accumulation and cognitive decline in 3 independent samples of clinically normal individuals. METHODS:Sequential...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011214
更新日期:2021-01-26 00:00:00
abstract::A 34-year-old man presented with a 30-year history of spasmodic dysphonia. He developed a speech disturbance 1 month after a closed head injury due to a fall. Sighing, coughing, and crying were normal. He had a tremor of the right hand when he drew a vertical line. His out-stretched right hand had a minimal dystonic p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.3.827
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:With diagnostic criteria alterations, increased MRI availability, and awareness of therapies, temporal changes in incidence and prevalence rates may occur, with an increase in the proportion of mildly affected persons diagnosed with multiple sclerosis (MS). The authors assessed temporal trends in the delay fr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000178891.20579.64
更新日期:2005-10-11 00:00:00
abstract:OBJECTIVES:To test the hypothesis that neuropsychiatric symptomatology is predictive of the success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that this predictive value adds to that provided by other clinical, imaging, and genomic factors in a multivariate model. METHODS:One hun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f25b16
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Collagen abnormalities of skin have been reported among patients with ALS. However, little is known concerning glycosaminoglycans of the skin in ALS. Our objective was to clarify morphologic and biochemical findings of skin glycosaminoglycans among patients with ALS. METHODS:We performed morph...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.51.2.399
更新日期:1998-08-01 00:00:00
abstract::We evaluated four formulas for estimating the intra-blood-brain barrier (IBBB) synthesis of IgG in a computer model of two types of BBB damage and in 1,629 consecutively received pairs of CSF and serum. These four formulas were the IgG synthesis rate (SR), IgG(loc) (ie, local), IgG index, and IgG extended index. Resul...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.510
更新日期:1992-03-01 00:00:00
abstract::We performed a retrospective study to characterize the type, frequency, and timing of neurologic complications in patients with B-cell chronic lymphocytic leukemia (B-CLL). We reviewed 962 total charts with a median follow-up time of 57.5 months. There were 109 cases (11.3%) of neurologic complications, including 69 c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.2.407
更新日期:1997-02-01 00:00:00
abstract::We used riboflavin to treat a patient with lipid myopathy, reduced exercise capacity, intolerance to fasting, and reduced concentrations of carnitine in muscle and serum. Although carnitine concentrations did not change, exercise capacity doubled, and response to fasting improved. Muscle enzyme assay showed that palmi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.12.1557
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:To assess the medial plantar nerve action potential (NAP) and skin biopsy in the evaluation of suspected distal sensory neuropathies (SN) with normal routine nerve conduction studies (NCS). METHODS:A total of 110 consecutive patients with suspected distal SN and normal routine NCS underwent medial plantar NA...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000137036.26601.84
更新日期:2004-09-14 00:00:00
abstract:OBJECTIVE:To use the large dataset from the Tysabri Outreach: Unified Commitment to Health (TOUCH) program to compare progressive multifocal leukoencephalopathy (PML) risk with natalizumab extended interval dosing (EID) vs standard interval dosing (SID) in patients with multiple sclerosis (MS). METHODS:This retrospect...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008243
更新日期:2019-10-08 00:00:00
abstract::We studied 60 patients with idiopathic Parkinson disease with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficity. Significant correlations were found between the severity of brady kinesia and impaired performance on tests ass...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.2.133
更新日期:1982-02-01 00:00:00
abstract::We used electrophysiologic methods in the diagnosis of torsion dystonia and the evaluation of therapy in a 7-year-old child. Electromyographic (EMG) activity patterns in five leg muscles were recorded during specific voluntary and passive movements as well as during gait. We found patterns of coactivation in leg muscl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.8.1083
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:To survey brain death criteria throughout the world. BACKGROUND:The clinical diagnosis of brain death allows organ donation or withdrawal of support. Declaration of brain death follows a certain set of examinations. The code of practice throughout the world has not been systematically investigated. METHODS:...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.1.20
更新日期:2002-01-08 00:00:00
abstract:OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001925
更新日期:2015-09-15 00:00:00
abstract:OBJECTIVE:To characterize the present state of brain death (BD) determination in actual practice relative to contemporary American Academy of Neurology (AAN) guidelines. METHODS:We reviewed the charts of all adult (16 years and older) BD organ donors during 2011 from 68 heterogeneous hospitals in the Midwest United St...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000436938.70528.4a
更新日期:2013-12-03 00:00:00
abstract::We describe a familial disorder consisting of sleep apnea, anosmia, colorblindness, partial complex seizures, and cognitive dysfunction. The phenotypic expression of the syndrome suggests an autosomal dominant inheritance with incomplete penetrance. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.2.190
更新日期:1988-02-01 00:00:00
abstract::The role of gender in the pathogenesis of Alzheimer's disease (AD) is an important issue that remains controversial. We compared men and women in late-onset familial AD kindreds for the risk of developing AD by studying 26 well-characterized familial AD kindreds from the Oregon Alzheimer Disease Center and, for confir...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.1.126
更新日期:1996-01-01 00:00:00
abstract::I studied vimentin and desmin immunoreactivities in the skeletal muscle of 30 human fetuses and children ranging from 8 weeks' gestation to 2 years of age, and in 45 infants and children and five adults with developmental neuromuscular diseases. Acridine orange-RNA fluorescence also identified regenerating myofibers i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.8.1616
更新日期:1992-08-01 00:00:00
abstract::Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.6.652
更新日期:1980-06-01 00:00:00
abstract::A new generation of Atraumatic (blunt tipped) needles now exists in addition to the traditional Quincke (cutting tip) needles for LP. We wished to identify the optimal size and type of needle that should be used for this technique. Requirements include rapid and accurate transduction of CSF pressure and adequate flow ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.1.33
更新日期:1996-07-01 00:00:00
abstract::A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180517.70572.37
更新日期:2005-10-25 00:00:00
abstract:BACKGROUND AND PURPOSE:Persistently elevated intracranial pressure (ICP) has been associated with poor clinical outcome after severe brain injury, such as neurotrauma, intracerebral hemorrhage, and subarachnoidal hemorrhage. Although ICP monitoring is increasingly being used in intensive care treatment of patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.2.393
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF). METHODS:NF1 experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors usin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005792
更新日期:2018-07-10 00:00:00
abstract:OBJECTIVE:To establish a variant of sporadic prion disease as the sporadic form of fatal familial insomnia (FFI). BACKGROUND:FFI is a recently described prion disease characterized clinically by severe sleep impairment, dysautonomia, and motor signs, and pathologically by atrophy of thalamic nuclei, especially the med...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.9.1757
更新日期:1999-06-10 00:00:00
abstract:OBJECTIVES:(1) To assess the diagnostic accuracy of EMG in radiculopathy. (2) To evaluate the intrarater reliability and interrater reliability of EMG in radiculopathy. (3) To assess the presence of confirmation bias in EMG. METHODS:Three experienced academic electromyographers interpreted 3 compact discs with 20 EMG ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002292
更新日期:2016-01-19 00:00:00
abstract::A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.5.550
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency and types of change in "self" seen in frontotemporal dementia (FTD) and to determine the relative involvement of the nondominant and dominant frontal and temporal brain regions in FTD patients with or without changes in a sense of self using neuropsychology tests and neuroimaging. B...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.817
更新日期:2001-09-11 00:00:00
abstract::The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free kappa chains and CSF free lambda chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.8.1334
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181cb3e39
更新日期:2010-01-19 00:00:00
abstract:OBJECTIVE:To investigate whether tactile extinction alters the cortical somatosensory activations induced by hand vibration. BACKGROUND:Tactile extinction occurs mainly after right-brain lesions and consists of the inability to perceive a contralesional cutaneous stimulation when a similar stimulus is applied to the m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.3.571
更新日期:1999-02-01 00:00:00