Abstract:
:The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free kappa chains and CSF free lambda chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels of free kappa chains; free kappa:free lambda chain ratio; free kappa chain:albumin ratio; and IgG:albumin ratio. There were no differences in the level of free lambda chains or absolute concentration of IgG. A significant correlation was observed between free kappa chains and total IgG in MS and between free lambda chains and total IgG in infections, suggesting that the immune response was predominantly IgG-kappa in MS and IgG-lambda in infections.
journal_name
Neurologyjournal_title
Neurologyauthors
DeCarli C,Menegus MA,Rudick RAdoi
10.1212/wnl.37.8.1334subject
Has Abstractpub_date
1987-08-01 00:00:00pages
1334-8issue
8eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
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