Effect of hematin in porphyric neuropathy.

abstract：BACKGROUND AND OBJECTIVES:A number of familial temporal lobe epilepsies (TLE) have been recently recognized. Mutations in LGI1 (leucine-rich, glioma-inactivated 1 gene) have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF). The authors aimed to determ...

journal_title：Neurology

authors： Berkovic SF,Izzillo P,McMahon JM,Harkin LA,McIntosh AM,Phillips HA,Briellmann RS,Wallace RH,Mazarib A,Neufeld MY,Korczyn AD,Scheffer IE,Mulley JC

更新日期：2004-04-13 00:00:00

abstract：OBJECTIVE:To investigate the temporal relationship between inflammation and cerebral atrophy in a longitudinal study of 19 patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly contrast enhanced MRI examinations and monthly measurements of brain fractional volume (BFV) for an average of 4 (ra...

journal_title：Neurology

authors： Richert ND,Howard T,Frank JA,Stone R,Ostuni J,Ohayon J,Bash C,McFarland HF

更新日期：2006-02-28 00:00:00

abstract：:Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-trea...

journal_title：Neurology

authors： Turjanski N,Lees AJ,Brooks DJ

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of headaches in a Chinese elderly population. BACKGROUND:There are few headache surveys in the elderly. Previous studies have shown a low headache prevalence in Chinese. METHODS: TARGET POPULATION:eligible registered residents > or = 65 years old (N = 2,003) in two townships o...

journal_title：Neurology

authors： Wang SJ,Liu HC,Fuh JL,Liu CY,Lin KP,Chen HM,Lin CH,Wang PN,Hsu LC,Wang HC,Lin KN

更新日期：1997-07-01 00:00:00

abstract：:X-linked spinal and bulbar muscular atrophy (SBMA) is usually associated with feminization and hypogonadism. We were unable to find androgen receptor (AR) in the scrotal skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease. ...

journal_title：Neurology

authors： Matsuura T,Demura T,Aimoto Y,Mizuno T,Moriwaka F,Tashiro K

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:To verify the previously reported association between long-term use of β2-adrenoreceptor (β2AR) agonist and antagonist with reduced and increased risk of Parkinson disease (PD), respectively. METHODS:We obtained odds ratios (ORs) associating time of β2AR agonist and antagonist use with PD risk in nationwide ...

journal_title：Neurology

authors： Hopfner F,Wod M,Höglinger GU,Blaabjerg M,Rösler TW,Kuhlenbäumer G,Christensen K,Deuschl G,Pottegård A

更新日期：2019-07-09 00:00:00

abstract：BACKGROUND:Neutralizing antibodies (NAB) to interferon beta (IFNbeta) occur in about one-third of MS patients treated with IFNbeta-1b and there is an association with a loss of clinical and MRI efficacy. However, there are no data regarding the bioavailability of IFNbeta-1b in patients with and without NAB. METHODS:Th...

journal_title：Neurology

authors： Deisenhammer F,Reindl M,Harvey J,Gasse T,Dilitz E,Berger T

更新日期：1999-04-12 00:00:00

abstract：:We studied brain sections from 10 patients with the acquired immunodeficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML) by in situ hybridization with a biotin-labeled JC virus (JCV) DNA probe and by immunohistochemistry using antibody against the JCV capsid antigen. We compared the results w...

journal_title：Neurology

authors： Aksamit AJ,Gendelman HE,Orenstein JM,Pezeshkpour GH

更新日期：1990-07-01 00:00:00

abstract：:We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...

journal_title：Neurology

authors： Kishore A,Nygaard TG,de la Fuente-Fernandez R,Naini AB,Schulzer M,Mak E,Ruth TJ,Calne DB,Snow BJ,Stoessl AJ

更新日期：1998-04-01 00:00:00

abstract：:We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; range, 3.5 to 74 year...

journal_title：Neurology

authors： Schlienger RG,Knowles SR,Shear NH

更新日期：1998-10-01 00:00:00

abstract：:The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*epsilon2 allele took longer to att...

journal_title：Neurology

authors： Kantarci OH,Hebrink DD,Achenbach SJ,Pittock SJ,Altintas A,Schaefer-Klein JL,Atkinson EJ,De Andrade M,McMurray CT,Rodriguez M,Weinshenker BG

更新日期：2004-03-09 00:00:00

abstract：PURPOSE:To understand the role of the angiopoietin-like 6 gene (ANGPTL6) in intracranial aneurysms (IAs), we investigated its role in a large cohort of familial IAs. METHODS:Individuals with family history of IA were recruited to the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study. The ANGPTL6 gene was...

journal_title：Neurology

authors： Hostettler IC,O'Callaghan B,Bugiardini E,O'Connor E,Vandrovcova J,Davagnanam I,Alg V,Bonner S,Walsh D,Bulters D,Kitchen N,Brown MM,Grieve J,Werring DJ,Houlden H,Genetics and Observational Subarachnoid Haemorrhage (GOSH) Stu

更新日期：2020-10-26 00:00:00

abstract：:GM1 gangliosidosis is usually a pediatric disease caused by hereditary acid beta-galactosidase deficiency. There have been a few cases in adults. We saw a 51-year-old Japanese man with type 3 GM1 gangliosidosis who was manifesting dementia, dysarthria, gait disturbance, and limb rigidity. Radiologic studies showed pla...

journal_title：Neurology

authors： Ohta K,Tsuji S,Mizuno Y,Atsumi T,Yahagi T,Miyatake T

更新日期：1985-10-01 00:00:00

abstract：:This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...

journal_title：Neurology

authors： Goto S,Hirano A,Matsumoto S

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). METHODS:Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. After a 1-week washout they crossed over to the...

journal_title：Neurology

authors： Garcia-Borreguero D,Larrosa O,de la Llave Y,Verger K,Masramon X,Hernandez G

更新日期：2002-11-26 00:00:00

abstract：:A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...

journal_title：Neurology

authors： Capellari S,Parchi P,Wolff BD,Campbell J,Atkinson R,Posey DM,Petersen RB,Gambetti P

更新日期：2002-11-26 00:00:00

abstract：:To determine whether MRI can reveal more vascular lesions in patients clinically suspected of having vascular parkinsonism, we compared 15 such patients with 15 patients who had idiopathic Parkinson's disease and 10 hypertensive controls. Patients with suspected vascular parkinsonism had significantly more subcortical...

journal_title：Neurology

authors： Zijlmans JC,Thijssen HO,Vogels OJ,Kremer HP,Poels PJ,Schoonderwaldt HC,Merx JL,van 't Hof MA,Thien T,Horstink MW

更新日期：1995-12-01 00:00:00

abstract：:Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included kno...

journal_title：Neurology

authors： Cranford RE,Leppik IE,Patrick B,Anderson CB,Kostick B

更新日期：1979-11-01 00:00:00

abstract：:Two patients with acute onset of profound weakness and loss of muscle bulk during a critical illness had unusual histopathological changes of type II myofibers. Both patients had respiratory failure and prolonged neuromuscular blockade. High-dose steroids were used in only one case and atracurium in the other. Muscle ...

journal_title：Neurology

authors： Gutmann L,Blumenthal D,Gutmann L,Schochet SS

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To investigate brain amyloid pathology in a dementia-risk population defined as cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with normal cognition and to examine associations between brain amyloid load and cognitive performance and vascular risk factors. METHODS:A sub...

journal_title：Neurology

authors： Kemppainen N,Johansson J,Teuho J,Parkkola R,Joutsa J,Ngandu T,Solomon A,Stephen R,Liu Y,Hänninen T,Paajanen T,Laatikainen T,Soininen H,Jula A,Rokka J,Rissanen E,Vahlberg T,Peltoniemi J,Kivipelto M,Rinne JO

更新日期：2018-01-16 00:00:00

abstract：:The syndrome of increased intracranial pressure without hydrocephalus or mass lesion and with normal CSF composition, previously referred to as pseudotumor cerebri, is a diagnosis of exclusion now termed idiopathic intracranial hypertension (IIH). Diagnostic criteria of this disorder have not been updated since the Mo...

journal_title：Neurology

authors： Friedman DI,Jacobson DM

更新日期：2002-11-26 00:00:00

abstract：OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...

journal_title：Neurology

authors： Iglesias S,Chapon F,Baron JC

更新日期：2000-12-12 00:00:00

abstract：OBJECTIVE:Guillain-Barré syndrome (GBS) is characterized by nerve infiltration of leukocytes and autoantibodies of the immunoglobulin G (IgG) isotype directed against nerve constituents. Leukocyte receptors for IgG (FcgammaR) constitute an important link between the humoral and cellular parts of the immune system and c...

journal_title：Neurology

authors： van der Pol WL,van den Berg LH,Scheepers RH,van der Bom JG,van Doorn PA,van Koningsveld R,van den Broek MC,Wokke JH,van de Winkel JG

更新日期：2000-04-25 00:00:00

abstract：OBJECTIVE:This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors amo...

journal_title：Neurology

authors： Andrews RJ,Fonda JR,Levin LK,McGlinchey RE,Milberg WP

更新日期：2018-08-21 00:00:00

abstract：OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...

journal_title：Neurology

authors： Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

更新日期：2019-10-29 00:00:00

abstract：OBJECTIVE:This study assessed the tissue integrity of major cervical cord tracts by using diffusion tensor imaging (DTI) to determine the relationship with specific clinical functions carried by those tracts. METHODS:This was a cross-sectional study of 37 patients with multiple sclerosis or neuromyelitis optica with r...

journal_title：Neurology

authors： Naismith RT,Xu J,Klawiter EC,Lancia S,Tutlam NT,Wagner JM,Qian P,Trinkaus K,Song SK,Cross AH

更新日期：2013-06-11 00:00:00

abstract：:Lyme borreliosis (LB) causes a range of neurologic manifestations, the most common of which is facial nerve paralysis. To evaluate nervous system LB, we organized a neurologic collaborative study group in Suffolk County, NY, a region of high LB incidence. Between July and September 1989, LB serologies were performed o...

journal_title：Neurology

authors： Halperin JJ,Golightly M

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:UK veterans who were deployed to the Gulf in 1990 to 1991 reported higher prevalence of neuromuscular symptoms. OBJECTIVE:To investigate whether these Gulf War-related symptoms were associated with objective evidence of neuromuscular dysfunction. METHODS:Forty-nine Gulf War veterans with more than four neu...

journal_title：Neurology

authors： Sharief MK,Priddin J,Delamont RS,Unwin C,Rose MR,David A,Wessely S

更新日期：2002-11-26 00:00:00

abstract：:A right-handed woman with independent left- and right-sided temporal lobe discharges was studied by continuous EEG and videotape monitoring for 3 weeks. Changes in affect were noted in the immediate and extended postictal periods and varied with the side of discharge. After a left-sided discharge, she became globally ...

journal_title：Neurology

authors： Hurwitz TA,Wada JA,Kosaka BD,Strauss EH

更新日期：1985-09-01 00:00:00

abstract：:We report a patient with unusual MRI abnormalities that had the physical characteristics of ferromagnetic artifact. We believe that the MRI artifacts were due to microscopic embolic metal fragments, most likely from a mechanical heart valve prosthesis. Potential sources of metal emboli should be considered in patients...

journal_title：Neurology

authors： Wingerchuk DM,Krecke KN,Fulgham JR

更新日期：1997-11-01 00:00:00