Abstract:
:Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-treated PD patients. Untreated patients showed a 14% increase in mean D2 receptor binding in the putamen contralateral to the more affected limbs (p < 0.02). Treated patients were segregated into subgroups according to the presence or absence of dyskinesias. There were no differences in mean caudate and putamen D1 and D2 binding between dyskinetic and nondyskinetic patients, matched for duration of clinical disease. Both dyskinetic and nondyskinetic PD subgroups showed a similar 16% reduction of mean caudate D2 binding (p < 0.01) with normal D2 binding in putamen. Mean caudate and putamen D1 binding potentials of both subgroups were reduced by 10% compared with those of controls, though this trend did not reach significance. Putamen D1 binding, however, showed a negative correlation with duration and L-dopa treatment (p < 0.03). These findings suggest that, while exposure of PD patients to L-dopa may be associated with reductions in caudate D2 and caudate and putamen D1 receptor, dyskinesias are unlikely to result from alterations in striatal dopamine receptor binding.
journal_name
Neurologyjournal_title
Neurologyauthors
Turjanski N,Lees AJ,Brooks DJdoi
10.1212/wnl.49.3.717subject
Has Abstractpub_date
1997-09-01 00:00:00pages
717-23issue
3eissn
0028-3878issn
1526-632Xjournal_volume
49pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.170
更新日期:1979-02-01 00:00:00
abstract::Spinal muscular atrophy (SMA) is the most common fatal neuromuscular disease of infancy. SMA type I is the most severe and mortality is usually due to respiratory failure. In type II the disability is of later onset and less severe, and prognosis has improved primarily due to supportive care. Type III is the mildest f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183282.10946.c7
更新日期:2005-11-08 00:00:00
abstract::The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.6.780
更新日期:1979-06-01 00:00:00
abstract::Generic substitution is practiced widely in both hospital and community settings. There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol. We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2696
更新日期:1993-12-01 00:00:00
abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.259
更新日期:1986-02-01 00:00:00
abstract::Forty-seven consecutive patients presenting acutely with repetitive symptoms indicative of anterior circulation ischemia ("crescendo" transient ischemic attacks) were evaluated to identify clinical features that might reliably predict the presence of significant stenosis, ulceration, or both in the presumably symptoma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.2.198
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Cerebrovascular disease (CVD) may contribute to mild cognitive impairment (MCI). We sought to determine the relation of white matter hyperintensity (WMH) volume and infarcts in brain MRI to MCI in a community-based sample. METHODS:A total of 679 elderly persons without dementia underwent brain MRI. WMH and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181b1636a
更新日期:2009-08-11 00:00:00
abstract:OBJECTIVE:The present retrospective cohort study compares the long-term functional outcome, improvement or deterioration, of patients considered in a vegetative state (VS) or a minimally conscious state (MCS) 1 year after coma onset, then yearly for up to 5 years. METHODS:We reviewed the clinical courses of 12 patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e8e8df
更新日期:2010-07-20 00:00:00
abstract:BACKGROUND:Cross-sectional studies suggest gender differences in cognitive function and risk of AD in older persons. However, longitudinal studies comparing change in cognitive function and risk of AD in men and women have had mixed results. The authors investigated gender differences in rate of decline for different c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000065892.67099.2a
更新日期:2003-06-10 00:00:00
abstract::Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive supranuclear palsy (PSP) and 4 controls. ChAT-immunoreactive neurons were quantified in sections that spanned the rostrocaudal extent of each nucleus. In PSP, t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.1.25
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD). METHODS:Cognitive deficits and rates of progression attributable to DLB and AD neuropathology were inve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180964.60708.c2
更新日期:2005-10-25 00:00:00
abstract::We analyzed the frequency of cardiac embolic sources in 62 patients with acute lacunar stroke vs 50 controls. In post hoc analysis, 11 patients with lacunar stroke having neither hypertension nor diabetes mellitus (non-HDM group) had a higher frequency of right-to-left shunt (RLS) (82%) than patients with risk factors...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000253197.83777.c7
更新日期:2007-02-13 00:00:00
abstract:OBJECTIVES:To determine the sensitivity and specificity of B-mode ultrasound in the diagnosis of neuromuscular diaphragmatic dysfunction, including phrenic neuropathy. METHODS:A prospective study of patients with dyspnea referred to the EMG laboratory over a 2-year time frame for evaluation of neuromuscular respirator...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000841
更新日期:2014-09-30 00:00:00
abstract:BACKGROUND:Neutralizing antibodies (NAB) to interferon beta (IFNbeta) occur in about one-third of MS patients treated with IFNbeta-1b and there is an association with a loss of clinical and MRI efficacy. However, there are no data regarding the bioavailability of IFNbeta-1b in patients with and without NAB. METHODS:Th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.6.1239
更新日期:1999-04-12 00:00:00
abstract:OBJECTIVE:To assess the role of CHCHD2 variants in patients with Parkinson disease (PD) and Lewy body disease (LBD) in Caucasian populations. METHODS:All exons of the CHCHD2 gene were sequenced in a US Caucasian patient-control series (878 PD, 610 LBD, and 717 controls). Subsequently, exons 1 and 2 were sequenced in a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002170
更新日期:2015-12-08 00:00:00
abstract::There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.30.7_part_2.8
更新日期:1980-07-01 00:00:00
abstract::We describe an atypical neurologic presentation of Wegener's granulomatosis (WG) with striking meningeal and cerebral involvement, responding to immunosuppressive therapy. WG may cause treatable intracranial complications in the absence of nasal or renal disease and without cerebral angiographic abnormalities, CSF ple...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.9.1831
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To determine the risk of seizure recurrence after a first seizure due to neurocysticercosis (NC) and to evaluate risk factors for seizure recurrence, including the influence of antihelminthic treatment. METHODS:The authors prospectively followed 77 patients with a first seizure and active or transitional NC ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000036320.69823.ea
更新日期:2002-12-10 00:00:00
abstract::A population-based case-control study in western Washington state was performed to assess the relation between head trauma and meningioma. Based on 200 case and 400 control subjects, head trauma was associated with an increased risk of meningioma (odds ratio = 1.83; 95% CI = 1.28, 2.62), especially head traumas occurr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.12.1849
更新日期:2002-06-25 00:00:00
abstract:OBJECTIVE:To assess hearing in patients with essential tremor (ET) vs patients with Parkinson disease (PD) and normal controls. METHODS:The authors assessed demographic and clinical information including use of hearing aids in 250 patients with ET, 127 patients with PD, and 127 normal controls. The authors administere...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000086376.40750.af
更新日期:2003-10-28 00:00:00
abstract::We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; range, 3.5 to 74 year...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.4.1172
更新日期:1998-10-01 00:00:00
abstract::Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with 125I-protein A. The mean binding of 125I-protein A to oligodendrocyte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.540
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex. METHODS:We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex vi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006007
更新日期:2018-08-14 00:00:00
abstract::The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000208442.07548.71
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.7.1045
更新日期:2002-04-09 00:00:00
abstract:OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008389
更新日期:2019-10-29 00:00:00
abstract::We assayed serum folate levels of 60 patients with chronic fatigue syndrome (CFS) and found that 50% had values below 3.0 micrograms/l. Some patients with CFS are deficient in folic acid. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2645
更新日期:1993-12-01 00:00:00
abstract::Three patients presented with unilateral progressive optic neuropathy. None of these patients had signs of symptoms referable to the chiasm or eye, thus confining their decline in vision to the optic nerve. Clinical and neuroradiographic evidence suggested a meningioma involving the optic nerve at the orbital-canalicu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.6.597
更新日期:1982-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824b94e9
更新日期:2012-03-06 00:00:00
abstract::A 5-year-old child with clinical and radiologic evidence of Leigh syndrome (LS) showed a T-->C mutation at position nt 8993 in the mitochondrial DNA (instead of the more common T-->G substitution), resulting in an amino acid change from a highly conserved leucine to proline in subunit 6 of mitochondrial ATPase. The mu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.5.972
更新日期:1994-05-01 00:00:00