Sarcoid optic neuropathy.

abstract：OBJECTIVE:To evaluate levels of neurofilament light (NFL) and glial fibrillary acidic protein (GFAP) in CSF from patients with multiple sclerosis (MS) in relation to clinical progress of the disease. METHODS:CSF levels of NFL and GFAP were determined by sensitive ELISAs in 99 patients with different subtypes of MS, cl...

journal_title：Neurology

authors： Norgren N,Sundström P,Svenningsson A,Rosengren L,Stigbrand T,Gunnarsson M

更新日期：2004-11-09 00:00:00

abstract：OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...

journal_title：Neurology

authors： Mosconi L,Berti V,Quinn C,McHugh P,Petrongolo G,Varsavsky I,Osorio RS,Pupi A,Vallabhajosula S,Isaacson RS,de Leon MJ,Brinton RD

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Clostridium botulinum neurotoxin types A, B, and E cause most cases of the paralytic disease botulism. Little is known about the epidemiology, clinical features, or microbiology of botulism type F. METHODS:Cases of adult type F botulism were identified by review of data collected by CDC's National Botulism ...

journal_title：Neurology

authors： Gupta A,Sumner CJ,Castor M,Maslanka S,Sobel J

更新日期：2005-12-13 00:00:00

abstract：:An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...

journal_title：Neurology

authors： Lavi E,Montone KT,Rorke LB,Kliman HJ

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. PATIENTS/METHODS:We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. I...

journal_title：Neurology

authors： Jackson CE,Amato AA,Bryan WW,Wolfe GI,Sakhaee K,Barohn RJ

更新日期：1998-06-01 00:00:00

abstract：:Using diagnostic criteria from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, dementia was clinically diagnosed in 57 (62%) of 92 centenarians living in two northern Italian provinces. The condition was severely disabling in approximately 70% of the demented patients. Although clinica...

journal_title：Neurology

authors： Ravaglia G,Forti P,De Ronchi D,Maioli F,Nesi B,Cucinotta D,Bernardi M,Cavalli G

更新日期：1999-07-22 00:00:00

abstract：BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorienta...

journal_title：Neurology

authors： Monacelli AM,Cushman LA,Kavcic V,Duffy CJ

更新日期：2003-12-09 00:00:00

abstract：:The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...

journal_title：Neurology

authors： Rowan AJ,Binnie CD,de Beer-Pawlikowski NK,Goedhart DM,Gutter T,van der Geest P,Meinardi H,Meijer JW

更新日期：1979-11-01 00:00:00

abstract：:Normal human quadriceps muscle was transplanted into nude mice subcutaneously for periods of 1, 2, 3, 4, 6, and 8 weeks. At 1 week, there was myoblast and myotube formation with thin and thick filaments. After 2 weeks, there was myotube formation with partially cross-striated myofilaments, and formation of dyads or tr...

journal_title：Neurology

authors： Wakayama Y,Schotland DL,Bonilla E

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Seven loci for autosomal dominant hereditary spastic paraplegia (ADHSP) have been mapped. To date, two families of SPG12 (chromosome 19q13) have been analyzed; however, there is not enough clinical information on SPG12 to establish locus-phenotype correlations. METHODS:The authors studied 60 individuals fro...

journal_title：Neurology

authors： Orlacchio A,Kawarai T,Rogaeva E,Song YQ,Paterson AD,Bernardi G,St George-Hyslop PH

更新日期：2002-11-12 00:00:00

abstract：:Because Hughlings Jackson directed that his personal documents be destroyed upon his death, none of his own clinical records are known. However, we have discovered several pages of notes in the Royal London Hospital Archive written in 1893 by Jackson to his House Physician at Queen Square concerning his proposals for ...

journal_title：Neurology

authors： Swash M,Evans J

更新日期：2006-08-22 00:00:00

abstract：:Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...

journal_title：Neurology

authors： Fromm GH,Glass JD,Chattha AS,Martinez AJ,Silverman M

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Some patients with prosopagnosia have covert recognition, meaning that they retain some familiarity or knowledge of facial identity of which they are not aware. OBJECTIVE:To test the hypothesis that prosopagnosic patients with right occipitotemporal lesions and impaired face perception lack covert processin...

journal_title：Neurology

authors： Barton JJ,Cherkasova M,O'Connor M

更新日期：2001-10-09 00:00:00

abstract：:Duchenne muscular dystrophy manifested in one of girl twins. The twins were monozygous on the basis of red cell and HL antigens and skin graft compatibility. Karyotyping, including banding techniques, showed a normal number of chromosomes and a normal configuration of the X-chromosome in both twins. The twins were ide...

journal_title：Neurology

authors： Gomez MR,Engel AG,Dewald G,Peterson HA

更新日期：1977-06-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...

journal_title：Neurology

authors： Batista S,Alves C,d'Almeida OC,Afonso A,Félix-Morais R,Pereira J,Macário C,Sousa L,Castelo-Branco M,Santana I,Cunha L

更新日期：2017-07-04 00:00:00

abstract：OBJECTIVE:To characterize humoral response to cerebellum in patients with gluten ataxia. BACKGROUND:Gluten ataxia is a common neurologic manifestation of gluten sensitivity. METHODS:The authors assessed the reactivity of sera from patients with gluten ataxia (13), newly diagnosed patients with celiac disease without ...

journal_title：Neurology

authors： Hadjivassiliou M,Boscolo S,Davies-Jones GA,Grünewald RA,Not T,Sanders DS,Simpson JE,Tongiorgi E,Williamson CA,Woodroofe NM

更新日期：2002-04-23 00:00:00

abstract：:In 64 patients with Parkinson's disease (PD), the basal level of prolactin (PRL) was normal. Bromocriptine (BCT) caused a significant suppression of PRL in all parkinsonian patients and controls. When given after BCT treatment, thyrotropin-releasing hormone (TRH) induced a significantly lower PRL rise in recent-onset ...

journal_title：Neurology

authors： Laihinen A,Rinne UK

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:To compare access to caregiving between men and women with Parkinson disease (PD). METHODS:This was a cross-sectional and longitudinal study among participants with PD enrolled in the National Parkinson Foundation Parkinson's Outcomes Project from 2009 to 2014 at 21 international sites. The primary outcome m...

journal_title：Neurology

authors： Dahodwala N,Shah K,He Y,Wu SS,Schmidt P,Cubillos F,Willis AW

更新日期：2018-01-02 00:00:00

abstract：OBJECTIVE:To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. METHODS:Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) fr...

journal_title：Neurology

authors： Collij LE,Heeman F,Salvadó G,Ingala S,Altomare D,de Wilde A,Konijnenberg E,van Buchem M,Yaqub M,Markiewicz P,Golla SSV,Wottschel V,Wink AM,Visser PJ,Teunissen CE,Lammertsma AA,Scheltens P,van der Flier WM,Boellaard R

更新日期：2020-09-15 00:00:00

abstract：:The authors carried out a three-phase door-to-door survey in Atahualpa, Ecuador to assess epidemiologic and pathogenetic mechanisms of stroke. They found 10 stroke patients among 1,568 individuals aged > or =15 years (crude prevalence, 638 per 100,000). There was only one incident case (incidence, 64 per 100,000). Six...

journal_title：Neurology

authors： Del Brutto OH,Idrovo L,Mosquera A,Navas C,Santibáñez R,Cuesta F,Díaz-Calderón E

更新日期：2004-11-23 00:00:00

abstract：OBJECTIVE:Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. METHODS:We review the various mechani...

journal_title：Neurology

authors： Racke MK,Lovett-Racke AE,Karandikar NJ

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Both genetic and environmental factors play a role in the pathophysiology of MS and may influence the clinical expression of the disease. OBJECTIVE:To determine the contribution of familial factors to the clinical expression of MS. METHODS:The French Multiple Sclerosis Genetics Group identified 87 sibling ...

journal_title：Neurology

authors： Brassat D,Azais-Vuillemin C,Yaouanq J,Semana G,Reboul J,Cournu I,Mertens C,Edan G,Lyon-Caen O,Clanet M,Fontaine B

更新日期：1999-05-12 00:00:00

abstract：:We report the occurrence of neurologic complications in 23 patients who underwent gastric restriction surgery for the treatment of morbid obesity. Complications occurred 3 to 20 months after surgery. All the patients had had protracted vomiting for the first 3 months after the operation. The following syndromes were f...

journal_title：Neurology

authors： Abarbanel JM,Berginer VM,Osimani A,Solomon H,Charuzi I

更新日期：1987-02-01 00:00:00

abstract：:Genetic factors are important in Alzheimer disease (AD) and Parkinson disease but have not been well characterized in Lewy body dementia (LBD). The authors obtained family history in patients from an autopsy series of AD and LBD and in living healthy controls. A family history of dementia was more common in both LBD a...

journal_title：Neurology

authors： Woodruff BK,Graff-Radford NR,Ferman TJ,Dickson DW,DeLucia MW,Crook JE,Arvanitakis Z,Brassler S,Waters C,Barker W,Duara R

更新日期：2006-06-27 00:00:00

abstract：:Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated...

journal_title：Neurology

authors： Hatanpaa KJ,Blass DM,Pletnikova O,Crain BJ,Bigio EH,Hedreen JC,White CL 3rd,Troncoso JC

更新日期：2004-08-10 00:00:00

abstract：:Five women are presented with a subacute pure pancerebellar syndrome of ataxia and dysarthria to emphasize that this illness may occur without anti-Purkinje-cell or anti-Yo antibodies, or associated systemic cancer. The syndrome evolved over weeks or less and stabilized in four of the patients. Three had had a precedi...

journal_title：Neurology

authors： Ropper AH

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence...

journal_title：Neurology

authors： Al-Yahyaee S,Al-Gazali LI,De Jonghe P,Al-Barwany H,Al-Kindi M,De Vriendt E,Chand P,Koul R,Jacob PC,Gururaj A,Sztriha L,Parrado A,Van Broeckhoven C,Bayoumi RA

更新日期：2006-04-25 00:00:00

abstract：OBJECTIVE:To identify phenotypic features of febrile seizures that can be used to reduce heterogeneity and thereby increase power in linkage analysis. BACKGROUND:Despite exciting discoveries in several rare pedigrees, the genetic basis of common febrile seizures remains a mystery. The major drawback of studying common...

journal_title：Neurology

authors： Pal DK,Kugler SL,Mandelbaum DE,Durner M

更新日期：2003-02-11 00:00:00

abstract：OBJECTIVE:To determine whether blood-based biomarkers can differentiate older veterans with and without traumatic brain injury (TBI) and cognitive impairment (CogI). METHODS:We enrolled 155 veterans from 2 veterans' retirement homes: 90 without TBI and 65 with TBI history. Participants were further separated into CogI...

journal_title：Neurology

authors： Peltz CB,Kenney K,Gill J,Diaz-Arrastia R,Gardner RC,Yaffe K

更新日期：2020-09-01 00:00:00

abstract：:Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...

journal_title：Neurology

authors： Aubé M

更新日期：1999-01-01 00:00:00