Primary hyperparathyroidism and ALS: is there a relation?


BACKGROUND:An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. PATIENTS/METHODS:We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. In three patients, the diagnosis of PHP was made during the laboratory evaluation for motor neuron disease, and in one patient, the diagnosis of PHP preceded the onset of weakness by 5 months and in another by 2 years. Serum calcium levels in all five patients were elevated, ranging from 11.2 to 12.8 mg/dL (normal, <10.4 mg/dL), as were levels of parathyroid hormone (PTH). RESULTS:All five patients underwent parathyroid adenoma resection with subsequent normalization of serum calcium and PTH levels. Each patient had progressive weakness resulting in death 1 to 3 years following parathyroidectomy. CONCLUSION:Resection of parathyroid adenomas in patients meeting El Escorial criteria for ALS did not alter the course of ALS. PHP and ALS appear to be coexisting but unrelated disorders.






Jackson CE,Amato AA,Bryan WW,Wolfe GI,Sakhaee K,Barohn RJ




Has Abstract


1998-06-01 00:00:00












  • Benefits of rivastigmine on attention in dementia associated with Parkinson disease.

    abstract::In a 24-week, randomized, double-blind, placebo-controlled, multicenter study of rivastigmine, 487 patients with dementia associated with Parkinson disease underwent assessment of attention on the Cognitive Drug Research computerized cognitive assessment system before dosing and 16 and 24 weeks later. Significant bene...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wesnes KA,McKeith I,Edgar C,Emre M,Lane R

    更新日期:2005-11-22 00:00:00

  • Imitation synkinesia and sensory control of movement.

    abstract::Immitation synkinesia is usually associated with thalamic or parietal lesions. Analysis of three cases shows that the lesions may affect the posterior columns of the spinal cord or even the peripheral nervous system. In our cases, two facts stand out, a large measure of integrity of motor activity and predominant dist...


    pub_type: 杂志文章


    authors: Cambier J,Dehen H

    更新日期:1977-07-01 00:00:00

  • Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial.

    abstract:OBJECTIVE:To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS:A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month intervals IV over a 2-year per...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Krapf H,Morrissey SP,Zenker O,Zwingers T,Gonsette R,Hartung HP,MIMS Study Group.

    更新日期:2005-09-13 00:00:00

  • Retraction of the lower eyelid.

    abstract::Retraction of the lower eyelid is a useful sign of disease. It is an early manifestation of weakness of the facial muscles, occurring with myopathies, myasthenia, and upper and lower motor neuron facial paresis. Rarely, lower and upper lid retraction occur without proptosis in patients with Graves disease. Lower lid r...


    pub_type: 杂志文章


    authors: Cohen MM,Lessell S

    更新日期:1979-03-01 00:00:00

  • Methionine-enkephalin, substance P, and homovanillic acid in the CSF of parkinsonian patients.

    abstract::Methionine-enkephalin, substance P, and homovanillic acid concentrations were measured in the CSF of subjects not affected by neurologic disorders (group 1), and in parkinsonian patients who had a slight or moderate (group 2) or severe (group 3) disability. Homovanillic acid and substance P concentrations in the CSF o...


    pub_type: 杂志文章


    authors: Pezzoli G,Panerai AE,Di Giulio A,Longo A,Passerini D,Carenzi A

    更新日期:1984-04-01 00:00:00

  • "Dark Victory" (prognosis negative): The beginnings of neurology on screen.

    abstract::In "Dark Victory," released in theaters in 1939, the diagnosis and management of a progressive brain tumor was a central part of the screenplay, and this film marked the beginnings of the depiction of neurologic disease in cinema. Bette Davis' cinematic portrayal of a young woman dying from a brain tumor is close to t...


    pub_type: 历史文章,杂志文章


    authors: Wijdicks EFM

    更新日期:2016-04-12 00:00:00

  • Idiopathic intracranial hypertension: relationship to depression, anxiety, and quality of life.

    abstract:OBJECTIVE:To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not diagnosed with IIH (n ...


    pub_type: 杂志文章


    authors: Kleinschmidt JJ,Digre KB,Hanover R

    更新日期:2000-01-25 00:00:00

  • Seizures accelerate forgetting in patients with left-sided temporal lobe epilepsy.

    abstract::Ten patients with refractory temporal lobe epilepsy performed a word-position association learning task every 24 hours during video EEG monitoring. On 55 occasions recall performance was tested 30 minutes and 24 hours after the initial learning phase. Patients with left- but not right-sided temporal lobe epilepsy exhi...


    pub_type: 杂志文章


    authors: Jokeit H,Daamen M,Zang H,Janszky J,Ebner A

    更新日期:2001-07-10 00:00:00

  • Delineation of the movement disorders associated with FOXG1 mutations.

    abstract:OBJECTIVE:The primary objective of this research was to characterize the movement disorders associated with FOXG1 mutations. METHODS:We identified patients with FOXG1 mutations who were referred to either a tertiary movement disorder clinic or tertiary epilepsy service and retrospectively reviewed medical records, cli...


    pub_type: 杂志文章


    authors: Papandreou A,Schneider RB,Augustine EF,Ng J,Mankad K,Meyer E,McTague A,Ngoh A,Hemingway C,Robinson R,Varadkar SM,Kinali M,Salpietro V,O'Driscoll MC,Basheer SN,Webster RI,Mohammad SS,Pula S,McGowan M,Trump N,Jenkin

    更新日期:2016-05-10 00:00:00

  • Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS.

    abstract:OBJECTIVE:To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings. METHODS:Clinicians and scientists with expertise in the use of MRI i...


    pub_type: 共识发展会议,杂志文章,评审


    authors: Oh J,Ontaneda D,Azevedo C,Klawiter EC,Absinta M,Arnold DL,Bakshi R,Calabresi PA,Crainiceanu C,Dewey B,Freeman L,Gauthier S,Henry R,Inglese M,Kolind S,Li DKB,Mainero C,Menon RS,Nair G,Narayanan S,Nelson F,Pelleti

    更新日期:2019-03-12 00:00:00

  • Nonseptic cardiogenic cerebral embolic stroke: clinical-CT correlations.

    abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...


    pub_type: 杂志文章


    authors: Weisberg LA

    更新日期:1985-06-01 00:00:00

  • Early myocardial disease and cramping myalgia in Becker-type muscular dystrophy: a kindred.

    abstract::We present a clinical and morphological study concerning a kindred with slowly progressive X-linked muscular dystrophy (Becker type). Five males were affected; one died of heart failure at age 16. Severe and early cardiac disorder is unusual in this type of muscular dystrophy, and death at such an early age had not be...


    pub_type: 杂志文章


    authors: Kuhn E,Fiehn W,Schröder JM,Assmus H,Wagner A

    更新日期:1979-08-01 00:00:00

  • Incidence of contrast nephropathy from cerebral CT angiography and CT perfusion imaging.

    abstract::The incidence of contrast-induced nephropathy was examined in 1,075 patients receiving routine CT angiography and CT perfusion brain imaging at a single institution. Fifty-two patients had a creatinine rise of > or =0.5 mg/dL. In four patients (0.37%), the administration of IV contrast medium possibly contributed to r...


    pub_type: 杂志文章


    authors: Josephson SA,Dillon WP,Smith WS

    更新日期:2005-05-24 00:00:00

  • THIP treatment of Huntington's disease.

    abstract::We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...


    pub_type: 临床试验,杂志文章


    authors: Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

    更新日期:1983-05-01 00:00:00

  • Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis.

    abstract:OBJECTIVE:To report outcomes of pregnancies that occurred during the fingolimod clinical development program. METHODS:Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolim...


    pub_type: 杂志文章


    authors: Karlsson G,Francis G,Koren G,Heining P,Zhang X,Cohen JA,Kappos L,Collins W

    更新日期:2014-02-25 00:00:00

  • Characteristics of CADASIL in Korea: a novel cysteine-sparing Notch3 mutation.

    abstract:OBJECTIVE:To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. METHODS:The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis o...


    pub_type: 杂志文章


    authors: Kim Y,Choi EJ,Choi CG,Kim G,Choi JH,Yoo HW,Kim JS

    更新日期:2006-05-23 00:00:00

  • Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat.

    abstract::We evaluated the neuroprotective effect of MK-801, a noncompetitive, selective N-methyl-D-aspartate receptor antagonist, in a neonatal hypoxic-ischemic animal model. Seven-day-old rats underwent bilateral ligation of the carotid arteries followed by exposure to an 8% oxygen atmosphere for 1 hr. We sacrificed the anima...


    pub_type: 杂志文章


    authors: Hattori H,Morin AM,Schwartz PH,Fujikawa DG,Wasterlain CG

    更新日期:1989-05-01 00:00:00

  • Antiplatelets, ACE inhibitors, and statins combination reduces stroke severity and tissue at risk.

    abstract:BACKGROUND:Antiplatelets (APL), angiotensin-converting enzyme (ACE) inhibitors (ACEI), and statins (STAT) are commonly used for stroke prevention. The authors examined whether combination therapy with these agents has additive protective effects in reducing ischemic stroke severity. METHODS:The authors retrospectively...


    pub_type: 杂志文章


    authors: Kumar S,Savitz S,Schlaug G,Caplan L,Selim M

    更新日期:2006-04-25 00:00:00

  • Canine and human myasthenia gravis autoantibodies recognize similar regions on the acetylcholine receptor.

    abstract::Serum from 35 cases of naturally occurring acquired canine myasthenia gravis (MG) were assayed for patterns of autoantibody specificities against canine acetylcholine receptor (AChR) using monoclonal antibodies (mAbs) and antiserum against defined regions of the AChR as competitive inhibitors of autoantibody binding. ...


    pub_type: 杂志文章


    authors: Shelton GD,Cardinet GH,Lindstrom JM

    更新日期:1988-09-01 00:00:00

  • Horner's syndrome after coronary artery bypass surgery.

    abstract::We established the frequency of Horner's syndrome (HS) in 248 elective patients after coronary artery bypass surgery. Patients were evaluated neurologically pre- and post-operatively and 6 months after surgery. Nineteen patients (7.7%) developed unilateral HS postoperatively, 12 involving the left eye. The finding per...


    pub_type: 杂志文章


    authors: Barbut D,Gold JP,Heinemann MH,Hinton RB,Trifiletti RR

    更新日期:1996-01-01 00:00:00

  • Gustatory agnosia.

    abstract:OBJECTIVE:To report the assessment of a patient exhibiting gustatory agnosia. METHODS:Preoperative and postoperative neuropsychological, neuroimaging, and chemosensory evaluations were performed in a 39-year-old woman undergoing surgical treatment for intractable epilepsy. RESULTS:Preoperative MRIs showed bilateral (...


    pub_type: 杂志文章


    authors: Small DM,Bernasconi N,Bernasconi A,Sziklas V,Jones-Gotman M

    更新日期:2005-01-25 00:00:00

  • Familial recurrent Bell's palsy with ocular motor palsies.

    abstract::We studied a family in which the father and 7 of 10 children had episodes of Bell's palsy. Five of the eight affected family members also had ocular motor palsies. Facial nerve and blink reflex studies in four affected siblings demonstrated asymmetrically reduced amplitude of evoked responses without delayed conductio...


    pub_type: 杂志文章


    authors: Aldrich MS,Beck RW,Albers JW

    更新日期:1987-08-01 00:00:00

  • Response of cluster headache to psilocybin and LSD.

    abstract::The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin ...


    pub_type: 杂志文章


    authors: Sewell RA,Halpern JH,Pope HG Jr

    更新日期:2006-06-27 00:00:00

  • Factors influencing sweat gland innervation in diabetes.

    abstract:BACKGROUND:Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine which marker best detect...


    pub_type: 杂志文章


    authors: Liu Y,Billiet J,Ebenezer GJ,Pan B,Hauer P,Wei J,Polydefkis M

    更新日期:2015-04-21 00:00:00

  • Upgoing thumb sign: A sensitive indicator of brain involvement?

    abstract:OBJECTIVE:To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an upgoing thumb sign. METHODS:We previously reported an upgoing thumb sign as a subtle clinical finding in patients with tran...


    pub_type: 杂志文章


    authors: Hachinski V,Alsubaie R,Azarpazhooh MR

    更新日期:2017-07-25 00:00:00

  • Pilot age and expertise predict flight simulator performance: a 3-year longitudinal study.

    abstract:BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...


    pub_type: 杂志文章


    authors: Taylor JL,Kennedy Q,Noda A,Yesavage JA

    更新日期:2007-02-27 00:00:00

  • Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF.

    abstract:OBJECTIVE:In families with autosomal dominant partial epilepsy with auditory features (ADPEAF) with mutations in the LGI1 gene, we evaluated clustering of mutations within the gene and associations of penetrance and phenotypic features with mutation location and predicted effect (truncation or missense). METHODS:We ab...


    pub_type: 杂志文章


    authors: Ho YY,Ionita-Laza I,Ottman R

    更新日期:2012-02-21 00:00:00

  • Acute symptomatic seizures and hippocampus damage: DWI and MRS findings.

    abstract::The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with correspon...


    pub_type: 临床试验,杂志文章


    authors: Parmar H,Lim SH,Tan NC,Lim CC

    更新日期:2006-06-13 00:00:00

  • Current treatments of epilepsy.

    abstract::Medical therapy is the mainstay for epilepsy, with most patients well controlled on a single antiepileptic drug (AED). In this non-refractory group, many patients have medication side effects and occasional seizures. Approximately 30% of patients with partial epilepsy and 25% of patients with generalized epilepsy are ...


    pub_type: 杂志文章,评审


    authors: Nadkarni S,LaJoie J,Devinsky O

    更新日期:2005-06-28 00:00:00

  • Prevalence of repetitive and reward-seeking behaviors in Parkinson disease.

    abstract::We surveyed 297 patients with Parkinson disease (PD) with systematic screens and rigorous definitional criteria. Pathologic hypersexuality lifetime prevalence was 2.4%. Compulsive shopping was 0.7%. Combined with our pathologic gambling data, the lifetime prevalence of these behaviors was 6.1% and increases to 13.7% i...


    pub_type: 杂志文章


    authors: Voon V,Hassan K,Zurowski M,de Souza M,Thomsen T,Fox S,Lang AE,Miyasaki J

    更新日期:2006-10-10 00:00:00