Abstract:
:A 5-year-old child with clinical and radiologic evidence of Leigh syndrome (LS) showed a T-->C mutation at position nt 8993 in the mitochondrial DNA (instead of the more common T-->G substitution), resulting in an amino acid change from a highly conserved leucine to proline in subunit 6 of mitochondrial ATPase. The mutation was heteroplasmic and maternally inherited, and was present in high percentages in multiple tissues. This finding documents genetic heterogeneity of the ATPase 6 gene mutation associated with LS.
journal_name
Neurologyjournal_title
Neurologyauthors
Santorelli FM,Shanske S,Jain KD,Tick D,Schon EA,DiMauro Sdoi
10.1212/wnl.44.5.972subject
Has Abstractpub_date
1994-05-01 00:00:00pages
972-4issue
5eissn
0028-3878issn
1526-632Xjournal_volume
44pub_type
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