Apolipoprotein E genotype and memory in the sixth decade of life.

Abstract:

BACKGROUND:Virtually all adult studies of APOE genotypes and cognition have included individuals over 60. In older adults, epsilon 4 carriers may manifest greater cognitive asymmetries than non-epsilon 4 carriers even in the absence of overall mean differences. General cognitive ability may also be affected by aging and APOE genotype, but most studies have inadequately addressed this potential confound. The goals of this study were to examine, in middle age, the relationship of APOE genotype with episodic memory and verbal-visuospatial episodic memory asymmetries, after accounting for prior general cognitive ability. METHOD:We compared epsilon 4+ and epsilon 4- individuals in 626 male twins in their 50s. We examined verbal and visuospatial episodic memory and verbal-visual asymmetry scores after adjusting for cognitive ability at age 20. Analyses corrected for correlations between twin pair members. RESULTS:Compared with epsilon 4- individuals, epsilon 4 carriers performed significantly more poorly on verbal, but not visuospatial memory, manifested significantly greater cognitive asymmetry, and also had significantly more concerns about memory. At age 20, epsilon 4 carriers had higher general cognitive ability than epsilon 4- individuals, and current memory differences were enhanced after adjusting for age 20 cognitive ability. CONCLUSIONS:Small, but significant, APOE-epsilon 4-related memory deficits appear in the sixth decade of life in individuals who show no signs of preclinical dementia. The results partially support studies of older adults that suggest that increased cognitive asymmetries reflect risk for dementia and are associated with the APOE-epsilon 4 genotype. The results also highlight the potential problems of not having accurate data on prior cognitive ability.

journal_name

Neurology

journal_title

Neurology

authors

Schultz MR,Lyons MJ,Franz CE,Grant MD,Boake C,Jacobson KC,Xian H,Schellenberg GD,Eisen SA,Kremen WS

doi

10.1212/01.wnl.0000286941.74372.cc

subject

Has Abstract

pub_date

2008-05-06 00:00:00

pages

1771-7

issue

19 Pt 2

eissn

0028-3878

issn

1526-632X

pii

01.wnl.0000286941.74372.cc

journal_volume

70

pub_type

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