Optimal combination secondary prevention drug treatment and stroke outcomes.

abstract：:The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and...

journal_title：Neurology

authors： Marder K,Maestre G,Cote L,Mejia H,Alfaro B,Halim A,Tang M,Tycko B,Mayeux R

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:To identify the genetic and physiologic basis for recessive myasthenic congenital myopathy in 2 families, suggestive of a channelopathy involving the sodium channel gene, SCN4A. METHODS:A combination of whole exome sequencing and targeted mutation analysis, followed by voltage-clamp studies of mutant sodium ...

journal_title：Neurology

authors： Elia N,Palmio J,Castañeda MS,Shieh PB,Quinonez M,Suominen T,Hanna MG,Männikkö R,Udd B,Cannon SC

更新日期：2019-03-26 00:00:00

abstract：:Alzheimer disease (AD) has a significant impact on caregivers. Administering and managing medications is one of their many daily tasks. More effective modes of drug administration may benefit patient and caregiver, and may improve compliance. A prospective outcome of the IDEAL (Investigation of TransDermal Exelon in A...

journal_title：Neurology

authors： Blesa R,Ballard C,Orgogozo JM,Lane R,Thomas SK

更新日期：2007-07-24 00:00:00

abstract：OBJECTIVE:To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. METHODS:A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 200...

journal_title：Neurology

authors： Wallin MT,Culpepper WJ,Campbell JD,Nelson LM,Langer-Gould A,Marrie RA,Cutter GR,Kaye WE,Wagner L,Tremlett H,Buka SL,Dilokthornsakul P,Topol B,Chen LH,LaRocca NG,US Multiple Sclerosis Prevalence Workgroup.

更新日期：2019-03-05 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of a mismatch between the severity of acute clinical manifestations and the diffusion-weighted imaging (DWI) lesion in predicting early stroke outcome and infarct volume. METHODS:One hundred sixty-six patients with a hemispheric ischemic stroke of <12 hours' duration were studied. ...

journal_title：Neurology

authors： Dávalos A,Blanco M,Pedraza S,Leira R,Castellanos M,Pumar JM,Silva Y,Serena J,Castillo J

更新日期：2004-06-22 00:00:00

abstract：OBJECTIVE:The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions. ME...

journal_title：Neurology

authors： Heuer HW,Mirsky JB,Kong EL,Dickerson BC,Miller BL,Kramer JH,Boxer AL

更新日期：2013-10-01 00:00:00

abstract：:We investigated blood-brain barrier (BBB) function in relation to Alzheimer's disease (AD) and vascular dementia (VAD) in the very elderly. Sixty-five 85-year-old persons from a population-based sample were followed for 3 years; 29 were demented at age 85 (13 with AD, 14 with VAD, and 2 with other dementias), 7 develo...

journal_title：Neurology

authors： Skoog I,Wallin A,Fredman P,Hesse C,Aevarsson O,Karlsson I,Gottfries CG,Blennow K

更新日期：1998-04-01 00:00:00

abstract：:With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications. In this article, four patient reports of a sp...

journal_title：Neurology

authors： Diamond S,Pepper BJ,Diamond ML,Freitag FG,Urban GJ,Erdemoglu AK

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...

journal_title：Neurology

authors： Siepmann T,Boardman H,Bilderbeck A,Griffanti L,Kenworthy Y,Zwager C,McKean D,Francis J,Neubauer S,Yu GZ,Lewandowski AJ,Sverrisdottir YB,Leeson P

更新日期：2017-03-28 00:00:00

abstract：OBJECTIVE:To test the hypothesis that ApoE isoforms affect mitochondrial structure and function that are related to cognitive impairment in Alzheimer disease (AD), we systematically investigated the effects of ApoE isoforms on mitochondrial biogenesis and dynamics, oxidative stress, synapses, and cognitive performance ...

journal_title：Neurology

authors： Yin J,Reiman EM,Beach TG,Serrano GE,Sabbagh MN,Nielsen M,Caselli RJ,Shi J

更新日期：2020-06-09 00:00:00

abstract：:We determined the gene frequencies for the alleles of the HLA-linked complement markers C2, properdin factor B (BF), C4A (Rodgers) and C4B (Chido), and the red cell enzyme glyoxalase-I in 38 unrelated patients with senile dementia of the Alzheimer type, 42 patients with idiopathic Parkinson's disease, and 59 unaffecte...

journal_title：Neurology

authors： Nerl C,Mayeux R,O'Neill GJ

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:About 20% of patients with familial hemiplegic migraine (FHM) develop progressive cerebellar signs. Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown. OBJECTIVE:To use proton MR spectroscopy (1H-M...

journal_title：Neurology

authors： Dichgans M,Herzog J,Freilinger T,Wilke M,Auer DP

更新日期：2005-02-22 00:00:00

abstract：:Since the introduction of computed tomography (CT), there have been numerous reports of brain abscess treated successfully without surgery. Because pathologic confirmation was lacking in these patients, diagnosis was based on CT abnormalities, usually ring enhancement. However, our recent clinical experience and the e...

journal_title：Neurology

authors： Dobkin JF,Healton EB,Dickinson PC,Brust JC

更新日期：1984-02-01 00:00:00

abstract：:To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure...

journal_title：Neurology

authors： Borasio GD,Robberecht W,Leigh PN,Emile J,Guiloff RJ,Jerusalem F,Silani V,Vos PE,Wokke JH,Dobbins T

更新日期：1998-08-01 00:00:00

abstract：:The authors evaluated education attainment and neuropsychological deficits in children with sickle cell disease (SCD) and silent cerebral infarcts. Children with silent infarcts had twice the rate of school difficulties as children without infarcts. Eighty percent of silent infarct cases had clinically significant cog...

journal_title：Neurology

authors： Schatz J,Brown RT,Pascual JM,Hsu L,DeBaun MR

更新日期：2001-04-24 00:00:00

abstract：OBJECTIVE:Parkinson disease (PD), a devastating neurodegenerative disorder, affects motor abilities and cognition as well. It is not clear whether the proapoptotic protein, Bid, is involved in tumor necrosis factor death receptor I (TNFRI)-mediated destructive signal transduction pathways such as cell dysfunction or ne...

journal_title：Neurology

authors： Jiang H,He P,Adler CH,Shill H,Beach TG,Li R,Shen Y

更新日期：2012-10-23 00:00:00

abstract：OBJECTIVE:To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). METHODS:A cross-sectional Internet-based physician survey of MS specialists was performed. RESULTS:The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported h...

journal_title：Neurology

authors： Solomon AJ,Klein EP,Bourdette D

更新日期：2012-06-12 00:00:00

abstract：:Immitation synkinesia is usually associated with thalamic or parietal lesions. Analysis of three cases shows that the lesions may affect the posterior columns of the spinal cord or even the peripheral nervous system. In our cases, two facts stand out, a large measure of integrity of motor activity and predominant dist...

journal_title：Neurology

authors： Cambier J,Dehen H

更新日期：1977-07-01 00:00:00

abstract：:We reviewed the prognostic significance of preoperative EEG findings in 25 patients who underwent functional hemispherectomy. Bilateral independent epileptogenic foci, found in five patients, generally indicate a less satisfactory outcome, with only three of the five patients becoming seizure free following hemisphere...

journal_title：Neurology

authors： Smith SJ,Andermann F,Villemure JG,Rasmussen TB,Quesney LF

更新日期：1991-11-01 00:00:00

abstract：:A 12-year-old girl who had zoster ophthalmicus 10 months earlier presented with hemiparesis and corresponding basal ganglionic infarction related to middle cerebral artery branch thrombosis ipsilateral to the zoster. Hematologic evaluation disclosed protein C deficiency. This represents the first zoster-associated str...

journal_title：Neurology

authors： Cadavid D,Pearl PL,Dubovsky EC,Angiolillo A,Vezina LG

更新日期：1999-09-22 00:00:00

abstract：:We evaluated the accuracy and interobserver variability of selected ictal and postictal behavioral changes. Three observers, blinded to clinical history, EEG, and side of surgical resection, analyzed videotapes of 166 seizures in 38 patients, looking for lateralizing signs. Twenty-seven patients with temporal lobe res...

journal_title：Neurology

authors： Chee MW,Kotagal P,Van Ness PC,Gragg L,Murphy D,Lüders HO

更新日期：1993-12-01 00:00:00

abstract：:4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for t...

journal_title：Neurology

authors： Smits RC,Emmen HH,Bertelsmann FW,Kulig BM,van Loenen AC,Polman CH

更新日期：1994-09-01 00:00:00

abstract：:Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...

journal_title：Neurology

authors： Ravits J,Hallett M,Baker M,Wilkins D

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:To investigate the association of PD with preceding head trauma using a case-control study design. METHODS:The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched ...

journal_title：Neurology

authors： Bower JH,Maraganore DM,Peterson BJ,McDonnell SK,Ahlskog JE,Rocca WA

更新日期：2003-05-27 00:00:00

abstract：OBJECTIVE:To test efficacy and safety of atorvastatin in subjects with clinically isolated syndrome (CIS). METHODS:Subjects with CIS were enrolled in a phase II, double-blind, placebo-controlled, 14-center randomized trial testing 80 mg atorvastatin on clinical and brain MRI activity. Brain MRIs were performed quarter...

journal_title：Neurology

authors： Waubant E,Pelletier D,Mass M,Cohen JA,Kita M,Cross A,Bar-Or A,Vollmer T,Racke M,Stüve O,Schwid S,Goodman A,Kachuck N,Preiningerova J,Weinstock-Guttman B,Calabresi PA,Miller A,Mokhtarani M,Iklé D,Murphy S,Kopetskie

更新日期：2012-04-10 00:00:00

abstract：OBJECTIVE:To describe the clinical features and outcome of anti-NMDA receptor (NMDAR) encephalitis in patients ≥45 years old. METHOD:Observational cohort study. RESULTS:In a cohort of 661 patients with anti-NMDAR encephalitis, we identified 31 patients ≥45 years old. Compared with younger adults (18-44 years), older ...

journal_title：Neurology

authors： Titulaer MJ,McCracken L,Gabilondo I,Iizuka T,Kawachi I,Bataller L,Torrents A,Rosenfeld MR,Balice-Gordon R,Graus F,Dalmau J

更新日期：2013-09-17 00:00:00

abstract：:Since cytomegalovirus (CMV) has been implicated in the pathogenesis of Rasmussen's syndrome, we treated four patients with ganciclovir, a potent anti-CMV drug. A 7-year-old girl with seizures escalating to 60/day over 3 months despite triple antiepileptic drug therapy became seizure-free 5 days after initiation of tre...

journal_title：Neurology

authors： McLachlan RS,Levin S,Blume WT

更新日期：1996-10-01 00:00:00

abstract：:The relevance of neutralizing antibodies (NAb) to interferon-beta (IFNbeta) for patients with MS treated with IFNbeta injections has been controversial. Published data from several double-blind, randomized clinical trials demonstrate that disease activity in IFNbeta-treated patients with MS is similar to placebo-treat...

journal_title：Neurology

authors： Rudick RA

更新日期：2003-11-11 00:00:00

abstract：:The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...

journal_title：Neurology

authors： Pinter JD,Brown WE,Eliez S,Schmitt JE,Capone GT,Reiss AL

更新日期：2001-04-10 00:00:00

abstract：:The local cerebral metabolic rate for glucose (1=CMRg) was computed in rats with methylphenidate-induced stereotypy using the quantitative 14C-2-deoxyglucose (2-DG) technique. Four rats received methylphenidate 15 mg per kilogram IP. Compared to five control animals, treated rats showed statistically significant (p le...

journal_title：Neurology

authors： Bell RD,Alexander GM,Schwartzman RJ,Yu J

更新日期：1982-04-01 00:00:00