Abstract:
:To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.
journal_name
Neurologyjournal_title
Neurologyauthors
Borasio GD,Robberecht W,Leigh PN,Emile J,Guiloff RJ,Jerusalem F,Silani V,Vos PE,Wokke JH,Dobbins Tdoi
10.1212/wnl.51.2.583subject
Has Abstractpub_date
1998-08-01 00:00:00pages
583-6issue
2eissn
0028-3878issn
1526-632Xjournal_volume
51pub_type
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