Pharmacologic management of seizures in organ transplant.

abstract：:Eighty-one percent (47/58) of private-sector neurologists in Colorado responded to a mail survey of practice patterns. We evaluated patient load, degree of principal versus consultative care, and use of neurodiagnostic tests. Broad areas of neurologic education that were perceived to have been lacking during residency...

journal_title：Neurology

authors： Franklin GM,Ringel SP,Nelson LM,DeLapp C

更新日期：1987-02-01 00:00:00

abstract：:We surveyed 297 patients with Parkinson disease (PD) with systematic screens and rigorous definitional criteria. Pathologic hypersexuality lifetime prevalence was 2.4%. Compulsive shopping was 0.7%. Combined with our pathologic gambling data, the lifetime prevalence of these behaviors was 6.1% and increases to 13.7% i...

journal_title：Neurology

authors： Voon V,Hassan K,Zurowski M,de Souza M,Thomsen T,Fox S,Lang AE,Miyasaki J

更新日期：2006-10-10 00:00:00

abstract：OBJECTIVE:To determine the incidence and predictors of acute cerebral ischemia and neurologic deterioration in intracerebral hemorrhage (ICH) patients after an institutional protocol change in systolic blood pressure (SBP) target from <160 to <140 mm Hg. METHODS:We retrospectively compared persons admitted with primar...

journal_title：Neurology

authors： Buletko AB,Thacker T,Cho SM,Mathew J,Thompson NR,Organek N,Frontera JA,Uchino K

更新日期：2018-09-11 00:00:00

abstract：:We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete s...

journal_title：Neurology

authors： Ishii N,Nishihara Y,Imamura T

更新日期：1986-03-01 00:00:00

abstract：:We administered the Mini-Mental State Exam (MMSE) to 194 healthy men and women, ages 40 to 89 years. Total score was significantly associated with age (p less than 0.0001), but not vocabulary, education, Beck's Depression Inventory Score, or sex. The lowest quartile cutoff scores for the MMSE by decade were 40s - 29; ...

journal_title：Neurology

authors： Bleecker ML,Bolla-Wilson K,Kawas C,Agnew J

更新日期：1988-10-01 00:00:00

abstract：:Biochemical analysis of muscle in a 37-year-old man with exercise intolerance, myalgia, recurrent myoglobinuria, and retinitis pigmentosa showed phosphoglycerate kinase (PGK) deficiency. Kinetic and physical characteristics of the mutant enzyme differed from those of two previously reported cases, suggesting a distinc...

journal_title：Neurology

authors： Tonin P,Shanske S,Miranda AF,Brownell AK,Wyse JP,Tsujino S,DiMauro S

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVES:To identify gene mutations in patients with dystroglycanopathy and prove pathogenicity of those mutations using an in vitro cell assay. METHODS:We performed whole-exome sequencing on 20 patients, who were previously diagnosed with dystroglycanopathy by immunohistochemistry and/or Western blot analysis. We a...

journal_title：Neurology

authors： Dong M,Noguchi S,Endo Y,Hayashi YK,Yoshida S,Nonaka I,Nishino I

更新日期：2015-01-20 00:00:00

abstract：BACKGROUND:Previous studies link posterior border-zone cerebral infarcts between the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) to hemodynamic causes, not embolism. OBJECTIVE:To study the cause of these infarcts. METHODS:We studied 21 patients (unilateral = 18, bilateral = 3) with acute, sym...

journal_title：Neurology

authors： Belden JR,Caplan LR,Pessin MS,Kwan E

更新日期：1999-10-12 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1 (CMT1) is associated with atrophy and degeneration of peripheral nerve axons in addition to prominent changes in the structure of Schwann cells. We have investigated the composition of the axonal cytoskeleton in sural nerve biopsies from patients with CMT1. Compared to controls, CMT1...

journal_title：Neurology

authors： Watson DF,Nachtman FN,Kuncl RW,Griffin JW

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter and access port in advanced PD. BACKGROUND:GDNF is a peptide that promotes survival of dopamine neurons. It improved 6-OHDA- or...

journal_title：Neurology

authors： Nutt JG,Burchiel KJ,Comella CL,Jankovic J,Lang AE,Laws ER Jr,Lozano AM,Penn RD,Simpson RK Jr,Stacy M,Wooten GF,ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor.

更新日期：2003-01-14 00:00:00

abstract：:Alzheimer disease (AD) has a significant impact on caregivers. Administering and managing medications is one of their many daily tasks. More effective modes of drug administration may benefit patient and caregiver, and may improve compliance. A prospective outcome of the IDEAL (Investigation of TransDermal Exelon in A...

journal_title：Neurology

authors： Blesa R,Ballard C,Orgogozo JM,Lane R,Thomas SK

更新日期：2007-07-24 00:00:00

abstract：BACKGROUND:There is a paucity of therapies for gait impairment in Parkinson disease (PD). Open-label studies have suggested improved gait after treatment with methylphenidate (MPD). OBJECTIVE:To evaluate the efficacy of MPD for the treatment of gait impairment in PD. METHODS:Twenty-seven subjects with PD and moderate...

journal_title：Neurology

authors： Espay AJ,Dwivedi AK,Payne M,Gaines L,Vaughan JE,Maddux BN,Slevin JT,Gartner M,Sahay A,Revilla FJ,Duker AP,Shukla R

更新日期：2011-04-05 00:00:00

abstract：:Methionine-enkephalin, substance P, and homovanillic acid concentrations were measured in the CSF of subjects not affected by neurologic disorders (group 1), and in parkinsonian patients who had a slight or moderate (group 2) or severe (group 3) disability. Homovanillic acid and substance P concentrations in the CSF o...

journal_title：Neurology

authors： Pezzoli G,Panerai AE,Di Giulio A,Longo A,Passerini D,Carenzi A

更新日期：1984-04-01 00:00:00

abstract：:Functional decline for each decade at symptom onset and need for cane, walker, or wheelchair were assessed in 78 biopsy-proved patients with sporadic inclusion body myositis. Patients with disease onset between 40 and 59 years used a walker after 10.2 +/- 5.8 years, whereas those with disease onset between 60 and 79 y...

journal_title：Neurology

authors： Peng A,Koffman BM,Malley JD,Dalakas MC

更新日期：2000-07-25 00:00:00

abstract：BACKGROUND:Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system. The authors performed MRS to characterize metabolic alterations and their regional variation in brain tissue in GLD in vivo. METHODS:Abnormalities of cerebral ...

journal_title：Neurology

authors： Brockmann K,Dechent P,Wilken B,Rusch O,Frahm J,Hanefeld F

更新日期：2003-03-11 00:00:00

abstract：:The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...

journal_title：Neurology

authors： Mula M,Trimble MR,Yuen A,Liu RS,Sander JW

更新日期：2003-09-09 00:00:00

abstract：:The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infar...

journal_title：Neurology

authors： van der Worp HB,Kappelle LJ,Algra A,Bär PR,Orgogozo JM,Ringelstein EB,Bath PM,van Gijn J,TESS Investigators.,TESS II Investigators.

更新日期：2002-01-08 00:00:00

abstract：BACKGROUND:In a recent study, the authors found that blinks in healthy volunteers always triggered ocular torsion quick phases during dynamic roll movements of the head. On the basis of this observation, they hypothesized that blinks in patients with a vestibular tone imbalance would also trigger torsional quick phases...

journal_title：Neurology

authors： Schneider E,Glasauer S,Dieterich M,Kalla R,Brandt T

更新日期：2004-10-12 00:00:00

abstract：OBJECTIVE:To assess the onset of ocrelizumab efficacy on brain MRI measures of disease activity in the phase II study in relapsing-remitting multiple sclerosis (RRMS), and relapse rate in the pooled phase III studies in relapsing multiple sclerosis (RMS). METHODS:Brain MRI activity was determined in the phase II trial...

journal_title：Neurology

authors： Barkhof F,Kappos L,Wolinsky JS,Li DKB,Bar-Or A,Hartung HP,Belachew S,Han J,Julian L,Sauter A,Napieralski J,Koendgen H,Hauser SL

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Antiplatelets (APL), angiotensin-converting enzyme (ACE) inhibitors (ACEI), and statins (STAT) are commonly used for stroke prevention. The authors examined whether combination therapy with these agents has additive protective effects in reducing ischemic stroke severity. METHODS:The authors retrospectively...

journal_title：Neurology

authors： Kumar S,Savitz S,Schlaug G,Caplan L,Selim M

更新日期：2006-04-25 00:00:00

abstract：:To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...

journal_title：Neurology

authors： Wilson JM,Levey AI,Rajput A,Ang L,Guttman M,Shannak K,Niznik HB,Hornykiewicz O,Pifl C,Kish SJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is a neurodegenerative disease associated with marked impairments in health-related quality of life (HRQoL). Although standard clinical end points such as the Expanded Disability Status Scale and annualized relapse rate remain useful in assessing MS activity and severity, these measur...

journal_title：Neurology

authors： Miller D,Rudick RA,Hutchinson M

更新日期：2010-04-27 00:00:00

abstract：:The role of gender in the pathogenesis of Alzheimer's disease (AD) is an important issue that remains controversial. We compared men and women in late-onset familial AD kindreds for the risk of developing AD by studying 26 well-characterized familial AD kindreds from the Oregon Alzheimer Disease Center and, for confir...

journal_title：Neurology

authors： Payami H,Montee K,Grimslid H,Shattuc S,Kaye J

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...

journal_title：Neurology

authors： Iglesias S,Chapon F,Baron JC

更新日期：2000-12-12 00:00:00

abstract：OBJECTIVE:To review the disciplinary process by which the American Academy of Neurology (AAN) enforces its formalized standards of professional conduct. METHODS:We reviewed the AAN's Disciplinary Action Policy. We tracked the elapsed time from receipt to final decision of all allegations ("complaints") of improper con...

journal_title：Neurology

authors： Hutchins JC,Sagsveen MG,Larriviere D

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:There are no published MRI studies comparing interferon beta 1b (IFNbeta-1b) and glatiramer acetate (GA) for treatment of relapsing multiple sclerosis (MS). OBJECTIVE:To compare the efficacy of IFNbeta-1b and GA for suppression of MS disease activity as evidenced on frequent brain MRI. METHODS:A total of 7...

journal_title：Neurology

authors： Cadavid D,Wolansky LJ,Skurnick J,Lincoln J,Cheriyan J,Szczepanowski K,Kamin SS,Pachner AR,Halper J,Cook SD

更新日期：2009-06-09 00:00:00

abstract：:The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...

journal_title：Neurology

authors： Cole SR,Beck RW,Moke PS,Kaufman DI,Tourtellotte WW

更新日期：1998-09-01 00:00:00

abstract：:The authors pooled four population-based European studies to determine the risk for institutionalization and death after stroke. Risk for institutionalization was assessed in 13,095 subjects. Survival was calculated for prevalent stroke in 7929 individuals and incident stroke in 8550 individuals. The adjusted risk of ...

journal_title：Neurology

authors： Schmidt R,Breteler MM,Inzitari D,Fratiglioni L,Hofman A,Launer LJ

更新日期：2000-01-01 00:00:00

abstract：:Evidence suggests that untreated obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, and stroke. Conversely, the systemic effects of a wide variety of critical illnesses can lead to CNS dysfunction, which can precipitate respiratory failure. Reported is a patient in whom an acute encephalop...

journal_title：Neurology

authors： Dyken ME,Yamada T,Berger HA

更新日期：2003-05-27 00:00:00

abstract：:Zinc is essential for normal embryogenesis and may have particular importance for closure of the human neural tube. Compared to 258 controls, we found increased zinc content in umbilical cord serum in eight of nine newborn anencephalics (p less than 0.02) and three infants with spina bifida (p less than 0.001). Increa...

journal_title：Neurology

authors： Zimmerman AW

更新日期：1984-04-01 00:00:00