Abstract:
:Methionine-enkephalin, substance P, and homovanillic acid concentrations were measured in the CSF of subjects not affected by neurologic disorders (group 1), and in parkinsonian patients who had a slight or moderate (group 2) or severe (group 3) disability. Homovanillic acid and substance P concentrations in the CSF of groups 2 and 3 were respectively lower and higher than in group 1. On the contrary, an increase in CSF methionine-enkephalin content was found only in group 2. Our results confirm in humans the close relation between the dopaminergic and peptidergic transmissions in the nigrostriatal system that has been observed in experimental animals.
journal_name
Neurologyjournal_title
Neurologyauthors
Pezzoli G,Panerai AE,Di Giulio A,Longo A,Passerini D,Carenzi Adoi
10.1212/wnl.34.4.516subject
Has Abstractpub_date
1984-04-01 00:00:00pages
516-9issue
4eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
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