Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study.


OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 patients (57 ± 9 years) without large infarcts had vascular screening and 1.5 T MRI at baseline and after a mean follow-up of 3.9 years. With automated brain segmentation, total brain, cortical gray matter, ventricular, and WML volumes were estimated and expressed relative to intracranial volume (%). Lacunar infarcts were rated manually. RESULTS:Using linear regression analyses adjusted for demographics and vascular risk factors, periventricular WML volume at baseline was associated with greater decrease in cortical gray matter volume (B = -1.73%, 95% confidence interval [CI] -3.15% to -0.30%, per 1% WML volume increase) and greater increase in ventricular volume (B = 0.12%, 95% CI 0.04% to 0.20%). Progression of periventricular WML volume corresponded with a greater decrease in cortical gray matter volume (B = -0.45%, 95% CI -0.9% to 0%) and greater increase in ventricular volume (B = 0.15%, 95% CI 0.1% to 0.2%). Presence of lacunar infarcts was associated with greater decline in total brain volume (B = -0.25%, 95% CI -0.49% to -0.01%) and progression of lacunar infarcts with a greater decrease of total brain (B = -0.30%, 95% CI -0.59% to 0.01%) and cortical gray matter volume (B = -0.81%, 95% CI -1.43% to -0.20%). CONCLUSIONS:In patients with symptomatic atherosclerotic disease, presence and progression of periventricular WML and lacunar infarcts is associated with greater progression of brain atrophy independent of vascular risk factors.






Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.




Has Abstract


2012-11-13 00:00:00














  • Mapping brain recovery after concussion: From acute injury to 1 year after medical clearance.

    abstract:OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...


    pub_type: 杂志文章


    authors: Churchill NW,Hutchison MG,Graham SJ,Schweizer TA

    更新日期:2019-11-19 00:00:00

  • Germline and mosaic mutations of FLN1 in men with periventricular heterotopia.

    abstract:OBJECTIVE:To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men. BACKGROUND:X-linked PNH caused by FLN1 mutations (MIM #300049) implies prenatal or early postnatal lethality in boys and 50% recurrence risk in daughters of affected women. MET...


    pub_type: 杂志文章


    authors: Guerrini R,Mei D,Sisodiya S,Sicca F,Harding B,Takahashi Y,Dorn T,Yoshida A,Campistol J,Krämer G,Moro F,Dobyns WB,Parrini E

    更新日期:2004-07-13 00:00:00

  • Subarachnoid and intracerebral hemorrhage: natural history, prognosis, and precursive factors in the Framingham Study.

    abstract::No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in...


    pub_type: 杂志文章


    authors: Sacco RL,Wolf PA,Bharucha NE,Meeks SL,Kannel WB,Charette LJ,McNamara PM,Palmer EP,D'Agostino R

    更新日期:1984-07-01 00:00:00

  • Experimental spinal cord injury: effects of trauma or ischemia on TRH and muscarinic receptors.

    abstract::Traumatic spinal cord injury in rats and ischemic spinal cord injury in rabbits were associated with time-dependent, localized decreases in thyrotropin-releasing hormone (TRH) and muscarinic receptor binding. Changes were not evident in the first 24 to 48 hours, consistent with the hypothesis that secondary alteration...


    pub_type: 杂志文章


    authors: Faden AI,Pilotte NS,Burt DR

    更新日期:1986-05-01 00:00:00

  • Three-Tesla MRI does not improve the diagnosis of multiple sclerosis: A multicenter study.

    abstract:OBJECTIVE:In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS:We recruited 66 patients with CIS within 6 months...


    pub_type: 杂志文章,多中心研究


    authors: Hagens MHJ,Burggraaff J,Kilsdonk ID,de Vos ML,Cawley N,Sbardella E,Andelova M,Amann M,Lieb JM,Pantano P,Lissenberg-Witte BI,Killestein J,Oreja-Guevara C,Ciccarelli O,Gasperini C,Lukas C,Wattjes MP,Barkhof F,MAGNIMS St

    更新日期:2018-07-17 00:00:00

  • A randomized controlled study of pergolide in patients with restless legs syndrome.

    abstract:BACKGROUND:Open clinical trials indicate that low doses of pergolide, a long-acting D1 and D2 dopamine agonist, lead to a reduction in the symptoms of restless legs syndrome (RLS) with subjective improvement in sleep quality. OBJECTIVE:To assess the therapeutic efficacy of pergolide in improving sleep and subjective m...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wetter TC,Stiasny K,Winkelmann J,Buhlinger A,Brandenburg U,Penzel T,Medori R,Rubin M,Oertel WH,Trenkwalder C

    更新日期:1999-03-23 00:00:00

  • The clinical profile of MS in Australia: a comparison between medium- and high-frequency prevalence zones.

    abstract::Recent epidemiologic studies of multiple sclerosis (MS) in Australia defined the State of Queensland as a medium-frequency zone and the more southerly placed cities of Perth, Newcastle, and Hobart as high-frequency zones. Clinical profiles in the patient populations of both frequency zones were remarkably similar in m...


    pub_type: 杂志文章


    authors: Hammond SR,English D,de Wytt C,Maxwell IC,Millingen KS,Stewart-Wynne EG,McLeod JG,McCall MG

    更新日期:1988-06-01 00:00:00

  • Intravenous t-PA for acute ischemic stroke: therapeutic yield of a stroke code system.

    abstract::Subsequent to publication of the NINDS t-PA Stroke Study results, we sought to determine the proportion of patients eligible for and receiving intravenous tissue plasminogen activator (t-PA) at an active acute stroke treatment center. Over a 12-month period there were 185 stroke code activations. Of these, 134 involve...


    pub_type: 杂志文章


    authors: Zweifler RM,Brody ML,Graves GC,U TT,Drinkard R,Cunningham S,Rothrock JF

    更新日期:1998-02-01 00:00:00

  • Risk of Parkinson's disease among first-degree relatives: A community-based study.

    abstract:OBJECTIVE:To determine the relative risk (RR) and cumulative incidence of idiopathic Parkinson's disease (PD) in first-degree relatives of PD patients compared with relatives of controls from the same geographic region. DESIGN:A family history questionnaire was used to obtain information on all first-degree relatives ...


    pub_type: 杂志文章


    authors: Marder K,Tang MX,Mejia H,Alfaro B,Côté L,Louis E,Groves J,Mayeux R

    更新日期:1996-07-01 00:00:00

  • Reduced contrast sensitivity in compressive lesions of the anterior visual pathway.

    abstract::A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...


    pub_type: 杂志文章


    authors: Kupersmith MJ,Siegel IM,Carr RE

    更新日期:1981-05-01 00:00:00

  • Chiasmal apoplexy: hemorrhage from a cryptic vascular malformation in the optic chiasm.

    abstract::We describe three patients with acute chiasmal visual field loss caused by hemorrhage within an intrachiasmal arteriovenous malformation. One patient had five episodes; vision improved three times without treatment and twice after surgical decompression. Surgical intervention restored vision in two of the three patien...


    pub_type: 杂志文章


    authors: Lavin PJ,McCrary JA 3rd,Roessmann U,Ellenberger C Jr

    更新日期:1984-08-01 00:00:00

  • Cerebrovascular perfusion in marijuana users during a month of monitored abstinence.

    abstract:OBJECTIVE:To determine possible effects of prolonged marijuana use on the cerebrovascular system during a month of monitored abstinence and to assess how the intensity of current use might have influenced cerebrovascular perfusion in these marijuana users. METHOD:The authors recorded blood flow velocity in the anterio...


    pub_type: 杂志文章


    authors: Herning RI,Better WE,Tate K,Cadet JL

    更新日期:2005-02-08 00:00:00

  • Increased florbetapir binding in the temporal neocortex from age 20 to 60 years.

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    pub_type: 杂志文章


    authors: Gonneaud J,Arenaza-Urquijo EM,Mézenge F,Landeau B,Gaubert M,Bejanin A,de Flores R,Wirth M,Tomadesso C,Poisnel G,Abbas A,Desgranges B,Chételat G

    更新日期:2017-12-12 00:00:00

  • Randomized, double-blind, dose-comparison study of glatiramer acetate in relapsing-remitting MS.

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Cohen JA,Rovaris M,Goodman AD,Ladkani D,Wynn D,Filippi M,9006 Study Group.

    更新日期:2007-03-20 00:00:00

  • Effect of comorbidity on mortality in multiple sclerosis.

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    pub_type: 杂志文章


    authors: Marrie RA,Elliott L,Marriott J,Cossoy M,Blanchard J,Leung S,Yu N

    更新日期:2015-07-21 00:00:00

  • Neurocognition, sleep, and PET findings in type 2 vs type 1 narcolepsy.

    abstract:OBJECTIVE:To analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective neuropsychologic tests, and sleep findings. METHODS:Data collection included comprehensive clinical investigation, study of ...


    pub_type: 杂志文章


    authors: Huang YS,Hsiao IT,Liu FY,Hwang FM,Lin KL,Huang WC,Guilleminault C

    更新日期:2018-04-24 00:00:00

  • Lorazepam treatment of experimental status epilepticus in the rat: relevance to clinical practice.

    abstract::We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE. Lorazepam entered the bloodstream rapidly following intraperitoneal injection. Brain concentrations peaked 10 minutes after peak serum levels w...


    pub_type: 杂志文章


    authors: Walton NY,Treiman DM

    更新日期:1990-06-01 00:00:00

  • Estimation of brainstem neuronal loss in amyotrophic lateral sclerosis with in vivo proton magnetic resonance spectroscopy.

    abstract::In vivo proton magnetic resonance spectroscopy (MRS) may be used to quantify brainstem neuronal degeneration in ALS because of the neuronal localization of N-acetylaspartate and N-acetylaspartylglutamate, together termed NA, which are estimated with this technique. We measured the ratio of NA to creatine/phosphocreati...


    pub_type: 杂志文章


    authors: Cwik VA,Hanstock CC,Allen PS,Martin WR

    更新日期:1998-01-01 00:00:00

  • Practice Parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:Nonmotor symptoms (sleep dysfunction, sensory symptoms, autonomic dysfunction, mood disorders, and cognitive abnormalities) in Parkinson disease (PD) are a major cause of morbidity, yet are often underrecognized. This evidence-based practice parameter evaluates treatment options for the nonmotor symptoms of P...


    pub_type: 杂志文章,实务指引


    authors: Zesiewicz TA,Sullivan KL,Arnulf I,Chaudhuri KR,Morgan JC,Gronseth GS,Miyasaki J,Iverson DJ,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

    更新日期:2010-03-16 00:00:00

  • Time course of frontal somatosensory evoked potentials. Relation to L-dopa plasma levels and motor performance in PD.

    abstract:OBJECTIVE:To verify whether the change in L-dopa plasma levels after a single dose of carbidopa/L-dopa 50/200 (controlled-release) transiently modifies frontal components of somatosensory evoked potentials (SEPs) in patients with PD in parallel with improvement of motor performance. BACKGROUND:Apomorphine, a potent do...


    pub_type: 杂志文章


    authors: Ulivelli M,Rossi S,Pasqualetti P,Rossini PM,Ghiglieri O,Passero S,Battistini N

    更新日期:1999-10-22 00:00:00

  • Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients.

    abstract:BACKGROUND:Given that vagal afferents project to brainstem regions that promote alertness, the authors tested the hypothesis that vagus nerve stimulation (VNS) would improve daytime sleepiness in patients with epilepsy. METHODS:Sixteen subjects with medically refractory seizures underwent polysomnography and multiple ...


    pub_type: 杂志文章


    authors: Malow BA,Edwards J,Marzec M,Sagher O,Ross D,Fromes G

    更新日期:2001-09-11 00:00:00

  • Internal carotid artery stent placement without emboli protection: results and long-term outcome.

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    pub_type: 临床试验,杂志文章


    authors: Bibl D,Lampl C,Biberhofer I,Kerschner K,Kypta A,Bergmann J,Kaindlstorfer A,Röper C,Yazdi K,Engleder C,Hofmann R,Deibl M,Leisch F,Ransmayr G

    更新日期:2005-07-12 00:00:00

  • Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT.

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    pub_type: 杂志文章


    authors: Parsons MW,Pepper EM,Bateman GA,Wang Y,Levi CR

    更新日期:2007-03-06 00:00:00

  • Incidence and prevalence of small-fiber neuropathy: a survey in the Netherlands.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Cohen BA

    更新日期:2008-12-09 00:00:00

  • Sample size estimations for MRI-monitored trials of MS comparing new vs standard treatments.

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    pub_type: 杂志文章


    authors: Sormani MP,Rovaris M,Bagnato F,Molyneux P,Bruzzi P,Pozzilli C,Miller DH,Comi G,Filippi M

    更新日期:2001-11-27 00:00:00

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    abstract:BACKGROUND:Studies have suggested that mood status is associated with an increased risk of stroke, though mostly based on measures of depression defined by symptoms alone rather than diagnostic criteria representative of clinically important distress and impairment. We investigated this association based upon a large p...


    pub_type: 杂志文章


    authors: Surtees PG,Wainwright NW,Luben RN,Wareham NJ,Bingham SA,Khaw KT

    更新日期:2008-03-04 00:00:00

  • Double-blind comparison of cabergoline and bromocriptine in Parkinson's disease patients with motor fluctuations.

    abstract::In the present study we compared the efficacy and safety of the new dopamine agonist cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the stud...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Inzelberg R,Nisipeanu P,Rabey JM,Orlov E,Catz T,Kippervasser S,Schechtman E,Korczyn AD

    更新日期:1996-09-01 00:00:00

  • Inflammatory markers and cognition in well-functioning African-American and white elders.

    abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...


    pub_type: 杂志文章


    authors: Yaffe K,Lindquist K,Penninx BW,Simonsick EM,Pahor M,Kritchevsky S,Launer L,Kuller L,Rubin S,Harris T

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  • Early penetration of the blood-brain-barrier by HIV.

    abstract::CNS dysfunction occurs frequently in patients with HIV infection. To better define the role of HIV in the pathogenesis of neurologic dysfunction, HIV isolation and antibody studies were investigated from the CSF in 52 seropositive patients, 29 with and 23 without neurologic signs and symptoms, in various stages of dis...


    pub_type: 杂志文章


    authors: Resnick L,Berger JR,Shapshak P,Tourtellotte WW

    更新日期:1988-01-01 00:00:00