Tuberculous meningitis in the southwest United States: a community-based study.

Abstract:

:This community-based study analyzed 54 patients with definite or probable tuberculous meningitis (TBM) in New Mexico from 1970 through 1990. Patients ranged in age from 4 months to 86 years. The highest age-specific incidence occurred in the elderly, but 22% of patients were less than 10 years old. Native American patients were overrepresented. Patients were as likely to live in small towns as in large urban cities. Symptoms were present for a median of 13 days before admission. The majority of patients had fevers, headache, stiff neck, and mental changes, such as confusion or lethargy. No patient was admitted comatose. Focal neurologic signs were present in 33%. Laboratory testing found hyponatremia in 79%, pulmonary infiltrates on chest x-ray in 40%, ventricular dilatation on CT or MRI in 52%, and tuberculomas in 16%. PPD skin tests were positive in 64%. CSF cultures grew Mycobacterium tuberculosis in 50%, but colony counts were always lower than 10(2)/ml. As a consequence, acid-fast stains of CSF sediment were reported as positive in only 4%. Six patients were not diagnosed during the hospitalization and died of complications. Twenty-three percent of patients who were appropriately treated also died of complications during the initial hospitalization. Tuberculous meningitis continues to be an important disease in small communities, and affects all ages and ethnic and socioeconomic backgrounds.

journal_name

Neurology

journal_title

Neurology

authors

Davis LE,Rastogi KR,Lambert LC,Skipper BJ

doi

10.1212/wnl.43.9.1775

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

1775-8

issue

9

eissn

0028-3878

issn

1526-632X

journal_volume

43

pub_type

杂志文章
  • Repetitive TMS temporarily alters brain diffusion.

    abstract::The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000058903.15205.46

    authors: Mottaghy FM,Gangitano M,Horkan C,Chen Y,Pascual-Leone A,Schlaug G

    更新日期:2003-05-13 00:00:00

  • Clinical course correlates poorly with muscle pathology in nemaline myopathy.

    abstract:OBJECTIVE:To report pathologic findings in 124 Australian and North American cases of primary nemaline myopathy. METHODS:Results of 164 muscle biopsies from 124 Australian and North American patients with primary nemaline myopathy were reviewed, including biopsies from 19 patients with nemaline myopathy due to alpha-a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000046585.81304.bc

    authors: Ryan MM,Ilkovski B,Strickland CD,Schnell C,Sanoudou D,Midgett C,Houston R,Muirhead D,Dennett X,Shield LK,De Girolami U,Iannaccone ST,Laing NG,North KN,Beggs AH

    更新日期:2003-02-25 00:00:00

  • Pharmacodynamics of the long-duration response to levodopa in PD.

    abstract:OBJECTIVE:To determine the latency, magnitude, and duration of the long-duration response (LDR) to levodopa in PD in relationship to the administration of levodopa at different interdose intervals. METHODS:In six patients with PD, two different 15-day treatment regimens were used in which the drug was administered wit...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.3.557

    authors: Zappia M,Bosco D,Plastino M,Nicoletti G,Branca D,Oliveri RL,Aguglia U,Gambardella A,Quattrone A

    更新日期:1999-08-11 00:00:00

  • Acute and prophylactic treatment of migraine: practical approaches and pharmacologic rationale.

    abstract::The antimigraine efficacy of many drugs may be mediated less through their primary modes of action than through the common pathway of serotonergic transmission stabilization. Migraine treatment may be symptomatic, acute/abortive, or prophylactic. Because oral drug absorption is impaired during attacks, parenteral agen...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:

    authors: Raskin NH

    更新日期:1993-06-01 00:00:00

  • Predicting developmental outcomes in preterm infants: A simple white matter injury imaging rule.

    abstract:OBJECTIVE:To develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction. METHODS:Sixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008172

    authors: Cayam-Rand D,Guo T,Grunau RE,Benavente-Fernández I,Synnes A,Chau V,Branson H,Latal B,McQuillen P,Miller SP

    更新日期:2019-09-24 00:00:00

  • APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers.

    abstract:BACKGROUND:Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and famili...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析

    doi:10.1212/01.wnl.0000210531.19498.3f

    authors: Burwick RM,Ramsay PP,Haines JL,Hauser SL,Oksenberg JR,Pericak-Vance MA,Schmidt S,Compston A,Sawcer S,Cittadella R,Savettieri G,Quattrone A,Polman CH,Uitdehaag BM,Zwemmer JN,Hawkins CP,Ollier WE,Weatherby S,Enzinger C

    更新日期:2006-05-09 00:00:00

  • HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS.

    abstract::The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.00...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.WNL.0000150579.54878.00

    authors: Cocco E,Sotgiu A,Costa G,Murru MR,Mancosu C,Murru R,Lai M,Contu P,Marrosu MG

    更新日期:2005-02-08 00:00:00

  • Solitary intracranial chloroma in a patient with chronic granulocytic leukemia.

    abstract::A rare case of solitary CNS chloroma in a patient with chronic granulocytic leukemia (CGL) is described. This appears to be the first reported case of intracranial chloroma in CGL without systemic blastic crisis. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.8.1089

    authors: Lysy J,Globus M,Okon E,Polliack A,Chowers I

    更新日期:1983-08-01 00:00:00

  • Expression and functional activity of heat shock proteins in human glioblastoma multiforme.

    abstract:OBJECTIVE:To assess the expression of heat shock proteins (HSP) in glioma cells in vitro and in vivo and to examine their role in resistance to apoptosis. BACKGROUND:HSP are expressed in response to various forms of stress. Constitutive HSP expression may confer resistance to cytotoxic stimuli in human cancers. METHO...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.6.1357

    authors: Hermisson M,Strik H,Rieger J,Dichgans J,Meyermann R,Weller M

    更新日期:2000-03-28 00:00:00

  • Combined defects of muscle phosphofructokinase and AMP deaminase in a child with myoglobinuria.

    abstract::A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.1.296

    authors: Bruno C,Minetti C,Shanske S,Morreale G,Bado M,Cordone G,DiMauro S

    更新日期:1998-01-01 00:00:00

  • Registry studies of long-term multiple sclerosis outcomes: description of key registries.

    abstract:BACKGROUND:Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lifespan. MS registries have been established in Canada, the United ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e3182050225

    authors: Hurwitz BJ

    更新日期:2011-01-04 00:00:00

  • Sensory Guillain-Barré syndrome.

    abstract:OBJECTIVE:To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND:The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.56.1.82

    authors: Oh SJ,LaGanke C,Claussen GC

    更新日期:2001-01-09 00:00:00

  • COMT inhibitors and liver toxicity.

    abstract::This paper reviews the issue of hepatotoxicity with the use of the catechol-O-methly transferase (COMT) inhibitors tolcapone and entacapone. Neither drug caused hepatotoxicity in preclinical toxicity testing. However, in clinical trials of tolcapone, liver chemistry tests were elevated more than 3 times above the uppe...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:

    authors: Watkins P

    更新日期:2000-01-01 00:00:00

  • Effect of ropinirole on sleep onset: a randomized, placebo-controlled study in healthy volunteers.

    abstract::Somnolence and "sleep attacks" have been reported as an adverse effect of several antiparkinsonian drugs. The authors document, in a placebo-controlled, randomized, double-blind, crossover study performed in 20 healthy volunteers, using the Multiple System Latency Test (MSLT) as primary outcome, that ropinirole reduce...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.58.3.460

    authors: Ferreira JJ,Galitzky M,Thalamas C,Tiberge M,Montastruc JL,Sampaio C,Rascol O

    更新日期:2002-02-12 00:00:00

  • Natural history of cavernous malformation: Systematic review and meta-analysis of 25 studies.

    abstract:OBJECTIVE:We pooled the results of studies on natural history of cavernous malformations (CM) to calculate point estimates and investigate main sources of heterogeneity. METHODS:We searched MEDLINE, EMBASE, and ISI Web of Science for relevant studies published before May 2015. We used fixed or random effects models an...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1212/WNL.0000000000002701

    authors: Taslimi S,Modabbernia A,Amin-Hanjani S,Barker FG 2nd,Macdonald RL

    更新日期:2016-05-24 00:00:00

  • Psychiatric adverse events during levetiracetam therapy.

    abstract::The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000078031.32904.0d

    authors: Mula M,Trimble MR,Yuen A,Liu RS,Sander JW

    更新日期:2003-09-09 00:00:00

  • Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study.

    abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182749f02

    authors: Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.

    更新日期:2012-11-13 00:00:00

  • Perinatal stroke in term infants with neonatal encephalopathy.

    abstract::In a prospective cohort of 124 encephalopathic term infants, six infants had an acute focal stroke. All six encephalopathic patients with strokes presented with seizures. Neurodevelopmental outcome at 30 months was abnormal in all six patients and significantly worse when compared with the entire cohort overall. These...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000129909.77753.c4

    authors: Ramaswamy V,Miller SP,Barkovich AJ,Partridge JC,Ferriero DM

    更新日期:2004-06-08 00:00:00

  • Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy.

    abstract:OBJECTIVE:To describe the clinical, genetic and MR characteristics of patients with familial mesial temporal lobe epilepsy (MTLE). DESIGN/METHODS:The familial occurrence of MTLE was identified by a systematic search of family history of seizures in patients followed in the authors' epilepsy clinic. All probands and, w...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.2.166

    authors: Kobayashi E,Lopes-Cendes I,Guerreiro CA,Sousa SC,Guerreiro MM,Cendes F

    更新日期:2001-01-23 00:00:00

  • Involvement of the human pedunculopontine nucleus region in voluntary movements.

    abstract:OBJECTIVE:The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the devel...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181f25b35

    authors: Tsang EW,Hamani C,Moro E,Mazzella F,Poon YY,Lozano AM,Chen R

    更新日期:2010-09-14 00:00:00

  • Clinical and prognostic subforms of new daily-persistent headache.

    abstract:BACKGROUND:According to the International Classification of Headache Disorders (ICHD)-2, primary daily headaches unremitting from onset are classified as new daily-persistent headache (NDPH) only if migraine features are absent. When migraine features are present, classification is problematic. METHODS:We developed a ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181dad5de

    authors: Robbins MS,Grosberg BM,Napchan U,Crystal SC,Lipton RB

    更新日期:2010-04-27 00:00:00

  • The humoral response in the pathogenesis of gluten ataxia.

    abstract:OBJECTIVE:To characterize humoral response to cerebellum in patients with gluten ataxia. BACKGROUND:Gluten ataxia is a common neurologic manifestation of gluten sensitivity. METHODS:The authors assessed the reactivity of sera from patients with gluten ataxia (13), newly diagnosed patients with celiac disease without ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.8.1221

    authors: Hadjivassiliou M,Boscolo S,Davies-Jones GA,Grünewald RA,Not T,Sanders DS,Simpson JE,Tongiorgi E,Williamson CA,Woodroofe NM

    更新日期:2002-04-23 00:00:00

  • Longitudinal evaluation of dementia of the Alzheimer type: a comparison of 3 standardized mental status examinations.

    abstract::We administered 3 commonly employed tests of mental status (the Information-Memory-Concentration test [IMC], the Mini-Mental State Examination [MMSE], and the Dementia Rating Scale [DRS]) to 92 patients with probable dementia of the Alzheimer type. The 3 tests were readministered to 55 of the patients (2-year subgroup...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.8.1225

    authors: Salmon DP,Thal LJ,Butters N,Heindel WC

    更新日期:1990-08-01 00:00:00

  • Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1.

    abstract:OBJECTIVE:To determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1). METHODS:Children 0.5-18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion. This consisted of children with NF1 with or withou...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002771

    authors: Avery RA,Mansoor A,Idrees R,Biggs E,Alsharid MA,Packer RJ,Linguraru MG

    更新日期:2016-06-14 00:00:00

  • Widening spectrum of congenital hemiplegia: Periventricular venous infarction in term neonates.

    abstract::MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. S...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000079370.28310.ea

    authors: Takanashi J,Barkovich AJ,Ferriero DM,Suzuki H,Kohno Y

    更新日期:2003-08-26 00:00:00

  • Methionine-enkephalin, substance P, and homovanillic acid in the CSF of parkinsonian patients.

    abstract::Methionine-enkephalin, substance P, and homovanillic acid concentrations were measured in the CSF of subjects not affected by neurologic disorders (group 1), and in parkinsonian patients who had a slight or moderate (group 2) or severe (group 3) disability. Homovanillic acid and substance P concentrations in the CSF o...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.4.516

    authors: Pezzoli G,Panerai AE,Di Giulio A,Longo A,Passerini D,Carenzi A

    更新日期:1984-04-01 00:00:00

  • Linking MRI to daily life experience: the example of poststroke depression.

    abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31824528b2

    authors: Lassalle-Lagadec S,Allard M,Dilharreguy B,Schweitzer P,Swendsen J,Sibon I

    更新日期:2012-01-31 00:00:00

  • Subdural empyema in bacterial meningitis.

    abstract:OBJECTIVE:To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS:Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS:Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%),...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182752d0e

    authors: Jim KK,Brouwer MC,van der Ende A,van de Beek D

    更新日期:2012-11-20 00:00:00

  • The impact of lesion side on acute stroke treatment.

    abstract:BACKGROUND:Only a small percentage of patients with acute stroke are treated with recombinant tissue plasminogen activator (rt-PA). OBJECTIVE:To investigate why patients with right-hemisphere strokes seem at high risk of not receiving rt-PA. METHODS:This study includes two phases. Phase 1: the authors compared demogr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000167608.94237.aa

    authors: Di Legge S,Fang J,Saposnik G,Hachinski V

    更新日期:2005-07-12 00:00:00

  • 3-Methylglutaconic aciduria type I redefined: a syndrome with late-onset leukoencephalopathy.

    abstract:OBJECTIVE:3-Methylglutaconic aciduria type I is a rare inborn error of leucine catabolism. It is thought to present in childhood with nonspecific symptoms; it was even speculated to be a nondisease. The natural course of disease is unknown. METHODS:This is a study on 10 patients with 3-methylglutaconic aciduria type I...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181f39a8a

    authors: Wortmann SB,Kremer BH,Graham A,Willemsen MA,Loupatty FJ,Hogg SL,Engelke UF,Kluijtmans LA,Wanders RJ,Illsinger S,Wilcken B,Cruysberg JR,Das AM,Morava E,Wevers RA

    更新日期:2010-09-21 00:00:00