Abstract:
:The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.002) in women carrying the APOE4 but not the DRB1-DQB1 predisposing genotype, suggesting in this subgroup of patients a reciprocal influence between these genes and gender in modulating clinical variability of the disease.
journal_name
Neurologyjournal_title
Neurologyauthors
Cocco E,Sotgiu A,Costa G,Murru MR,Mancosu C,Murru R,Lai M,Contu P,Marrosu MGdoi
10.1212/01.WNL.0000150579.54878.00subject
Has Abstractpub_date
2005-02-08 00:00:00pages
564-6issue
3eissn
0028-3878issn
1526-632Xpii
64/3/564journal_volume
64pub_type
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