Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis.


OBJECTIVE:This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS. PATIENTS:There were 30 clinically definite MS patients, with different disease courses. EXCLUSION CRITERIA:psychoactive/steroid treatments, mood disorders, acute relapse phase. MAIN OUTCOME MEASURES:Neuropsychological test results. Total (TLL) and frontal (FLL) lesion loads assessed from PD-weighted, T1-weighted (22 patients), and MTI (22 patients) MRI scans. Average lesion MT ratios (MTR) and analysis of the MTR histograms from brain tissue axial slabs on MTI scans. RESULTS:Patients with frontal lobe deficits (n=15) or memory impairment (n-17) had a higher TLL on PD scans (p=0.04 and p=0.01, respectively). Patients with frontal lobe deficits had higher FLL on PD scans (p=0.01) and TLL on MTI (p=0.03) scans. No significant relationships between the extent of T1-weighted lesion loads and the presence of any neuropsychological impairment. Mean MTR of both MS lesions and whole brain tissue was lower in patients with frontal lobe impairment (p=0.04). MRI lesion loads correlated significantly with some neuropsychological test scores. CONCLUSIONS:Lesion loads on PD-weighted MRI and MTI-derived measures are associated with cognitive decline in MS patients. Overall macroscopic and microscopic brain damage is more important than the corresponding regional brain disease in determining deficits of selective cognitive domains.






Rovaris M,Filippi M,Falautano M,Minicucci L,Rocca MA,Martinelli V,Comi G




Has Abstract


1998-06-01 00:00:00












  • Neurologic complications after gastric restriction surgery for morbid obesity.

    abstract::We report the occurrence of neurologic complications in 23 patients who underwent gastric restriction surgery for the treatment of morbid obesity. Complications occurred 3 to 20 months after surgery. All the patients had had protracted vomiting for the first 3 months after the operation. The following syndromes were f...


    pub_type: 杂志文章


    authors: Abarbanel JM,Berginer VM,Osimani A,Solomon H,Charuzi I

    更新日期:1987-02-01 00:00:00

  • Recurrence of ICH after resumption of anticoagulation with VK antagonists: CHIRONE study.

    abstract:OBJECTIVE:To evaluate the risk of recurrent intracranial hemorrhage (ICH) in patients on vitamin K antagonists (VKAs) after a first episode of ICH. METHODS:The Cerebral Haemorrhage in patients Restarting Oral Anticoagulant Therapy (CHIRONE) Study collected data of patients eligible for the study from the database of 2...


    pub_type: 杂志文章,多中心研究


    authors: Poli D,Antonucci E,Dentali F,Erba N,Testa S,Tiraferri E,Palareti G,Italian Federation of Anticoagulation Clinics (FCSA).

    更新日期:2014-03-25 00:00:00

  • Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients.

    abstract:OBJECTIVES:To test the hypothesis that neuropsychiatric symptomatology is predictive of the success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that this predictive value adds to that provided by other clinical, imaging, and genomic factors in a multivariate model. METHODS:One hun...


    pub_type: 杂志文章


    authors: Petrovski S,Szoeke CE,Jones NC,Salzberg MR,Sheffield LJ,Huggins RM,O'Brien TJ

    更新日期:2010-09-14 00:00:00

  • Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?

    abstract:OBJECTIVE:To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma. METHODS:We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié...


    pub_type: 杂志文章,多中心研究


    authors: Roux A,Edjlali M,Porelli S,Tauziede-Espariat A,Zanello M,Dezamis E,Zah-Bi G,Sanson M,Puget S,Capelle L,Varlet P,Oppenheim C,Pallud J

    更新日期:2019-01-01 00:00:00

  • Cerebrospinal fluid monoamine markers are decreased in dementia of the Alzheimer type with extrapyramidal features.

    abstract::We measured monoamine metabolites and biopterin in the CSF of 37 patients with dementia of the Alzheimer type (DAT), with or without extrapyramidal signs, and in 14 age-matched healthy controls. Compared with concentrations in DAT and controls, the concentrations of homovanillic acid (HVA) and biopterin were significa...


    pub_type: 杂志文章


    authors: Kaye JA,May C,Daly E,Atack JR,Sweeney DJ,Luxenberg JS,Kay AD,Kaufman S,Milstien S,Friedland RP

    更新日期:1988-04-01 00:00:00

  • Venlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trial.

    abstract:BACKGROUND:Tricyclic antidepressants (TCA) are often used in the treatment of painful polyneuropathy. Venlafaxine is a serotonin and weak noradrenaline reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of TCA. OBJECTIVE:To test if venlafaxine would relieve painful pol...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sindrup SH,Bach FW,Madsen C,Gram LF,Jensen TS

    更新日期:2003-04-22 00:00:00

  • Genetics of epilepsy: The testimony of twins in the molecular era.

    abstract:OBJECTIVE:Analysis of twins with epilepsy to explore the genetic architecture of specific epilepsies, to evaluate the applicability of the 2010 International League Against Epilepsy (ILAE) organization of epilepsy syndromes, and to integrate molecular genetics with phenotypic analyses. METHODS:A total of 558 twin pair...


    pub_type: 杂志文章


    authors: Vadlamudi L,Milne RL,Lawrence K,Heron SE,Eckhaus J,Keay D,Connellan M,Torn-Broers Y,Howell RA,Mulley JC,Scheffer IE,Dibbens LM,Hopper JL,Berkovic SF

    更新日期:2014-09-16 00:00:00

  • The anatomic basis of pure alexia.

    abstract::The behavioral and anatomic correlates of pure alexia were analyzed in 16 patients. Right homonymous hemianopia failed to appear in three patients, who had right achromatopsia instead. Color anomia and unilateral optic ataxia were seen in six patients. Memory defects were found in two patients. Visual agnosia was note...


    pub_type: 杂志文章


    authors: Damasio AR,Damasio H

    更新日期:1983-12-01 00:00:00

  • The long-term clinical outcome of myasthenia gravis in patients with thymoma.

    abstract::We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...


    pub_type: 杂志文章,评审


    authors: Bril V,Kojic J,Dhanani A

    更新日期:1998-10-01 00:00:00

  • The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.

    abstract:OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...


    pub_type: 杂志文章


    authors: Silverberg GD,Heit G,Huhn S,Jaffe RA,Chang SD,Bronte-Stewart H,Rubenstein E,Possin K,Saul TA

    更新日期:2001-11-27 00:00:00

  • Ictal SPECT during autonomic crisis in familial dysautonomia.

    abstract::The authors report results of SPECT cerebral perfusion studies in two patients with familial dysautonomia (FD) during dysautonomic crises and when clinically stable. SPECT imaging studies used 99mTc ethylene cysteine dimer. During dysautonomic crises, regions in the temporoparietal and frontal lobes had increased upta...


    pub_type: 杂志文章


    authors: Axelrod FB,Zupanc M,Hilz MJ,Kramer EL

    更新日期:2000-07-12 00:00:00

  • Increased risk of stroke in patients with chronic kidney disease after recurrent hypoglycemia.

    abstract:OBJECTIVE:In this study, we aimed to investigate the effect of hypoglycemia on cardiovascular outcomes in a sample of patients with chronic kidney disease (CKD). METHODS:Information about study participants was extracted from the National Health Insurance Research Database of Taiwan for the years 1998 through 2008. We...


    pub_type: 杂志文章


    authors: Yu TM,Lin CL,Chang SN,Sung FC,Kao CH

    更新日期:2014-08-19 00:00:00

  • Stroke recurrence within the time window recommended for carotid endarterectomy.

    abstract:OBJECTIVE:In the North Dublin Population Stroke Study, we investigated the risk of recurrent stroke within the 14-day time window recommended for endarterectomy. METHODS:In a population-based prospective cohort study, all ischemic stroke patients were identified over 1 year and categorized into those with (CS-positive...


    pub_type: 杂志文章,随机对照试验


    authors: Marnane M,Ni Chroinin D,Callaly E,Sheehan OC,Merwick A,Hannon N,Horgan G,Kyne L,Moroney J,McCormack PM,Dolan E,Duggan J,Williams D,Crispino-O'Connell G,Kelly PJ

    更新日期:2011-08-23 00:00:00

  • Atypical presentation of dopa-responsive dystonia: generalized hypotonia and proximal weakness.

    abstract::Dopa-responsive dystonia (DRD) is an autosomal dominant disorder typically presenting as dystonia with diurnal variability. Described is an 8-year-old boy who had had waddling gait, generalized hypotonia, and proximal weakness since early childhood. He responded well to low-dose L-dopa. He had a point mutation of the ...


    pub_type: 杂志文章


    authors: Kong CK,Ko CH,Tong SF,Lam CW

    更新日期:2001-09-25 00:00:00

  • Change in body mass index and risk of incident Alzheimer disease.

    abstract:OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...


    pub_type: 杂志文章


    authors: Buchman AS,Wilson RS,Bienias JL,Shah RC,Evans DA,Bennett DA

    更新日期:2005-09-27 00:00:00

  • Local alterations of hemostatic-fibrinolytic mechanisms in reforming subdural hematomas.

    abstract::Multiple chemical and coagulation determinations were undertaken on the subdural hematoma fluid from the reformed effusions of two patients. It was found that plasma or blood repeatedly reentered the subdural cavity. Coagulation studies compared the in vitro effects of subdural fluid with those of cerebrospinal fluid,...


    pub_type: 杂志文章


    authors: Labadie EL,Glover D

    更新日期:1975-07-01 00:00:00

  • Predictive value of sensory and cognitive evoked potentials for awakening from coma.

    abstract:OBJECTIVES:To determine the prognostic role of late auditory (N100) and cognitive evoked potentials (MMN) for awakening in a cohort of comatose patients categorized by etiology. METHODS:The authors prospectively studied a series of 346 comatose patients. Coma was caused by stroke (n = 125), trauma (n = 96), anoxia (n ...


    pub_type: 杂志文章


    authors: Fischer C,Luauté J,Adeleine P,Morlet D

    更新日期:2004-08-24 00:00:00

  • PM2.5 associated with gray matter atrophy reflecting increased Alzheimers risk in older women.

    abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...


    pub_type: 杂志文章


    authors: Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

    更新日期:2020-11-18 00:00:00

  • Forced collectionism after orbitofrontal damage.

    abstract::A collector is a person who collects things on purpose, either as a hobby or business, or for personal satisfaction, e.g., stamp, coin, or art collector. In such instances, the act of collecting things represents voluntary, controlled, goal-directed, selective searching. Pathologic patterns of collecting have been obs...


    pub_type: 杂志文章


    authors: Volle E,Beato R,Levy R,Dubois B

    更新日期:2002-02-12 00:00:00

  • Reversible cerebral vasoconstriction syndrome and cervical artery dissection in 20 patients.

    abstract:OBJECTIVES:To describe clinical-radiologic characteristics in a prospective series of patients having both confirmed reversible cerebral vasoconstriction syndrome (RCVS) and cervical artery dissection (CeAD). METHODS:From January 2004 to December 2011, from our prospective cohorts of RCVS and CeAD, we studied patients...


    pub_type: 杂志文章


    authors: Mawet J,Boukobza M,Franc J,Sarov M,Arnold M,Bousser MG,Ducros A

    更新日期:2013-08-27 00:00:00

  • Neurologic complications of autologous and allogeneic bone marrow transplantation in patients with leukemia: a comparative study.

    abstract::We retrospectively evaluated the neurologic complications in 425 patients who underwent bone marrow transplant (BMT) (310 allogeneic, 115 autologous) for leukemia. Forty-six patients (11%) developed 47 central and three peripheral neurologic complications. The most common complications were cerebral hemorrhage (3.8%),...


    pub_type: 杂志文章


    authors: Graus F,Saiz A,Sierra J,Arbaiza D,Rovira M,Carreras E,Tolosa E,Rozman C

    更新日期:1996-04-01 00:00:00

  • Correlations between magnetization transfer metrics and other magnetic resonance abnormalities in multiple sclerosis.

    abstract::Magnetization transfer imaging (MTI) is a magnetic resonance imaging (MRI) technique that is now used in multiple sclerosis (MS) studies, and is thought to have a higher pathological specificity than conventional T2-weighted imaging. This review outlines the correlations between magnetization transfer (MT) metrics and...


    pub_type: 杂志文章,评审


    authors: Rovaris M,Horsfield MA,Filippi M

    更新日期:1999-01-01 00:00:00

  • Child neurology: tick paralysis: a diagnosis not to miss.

    abstract::A 4-year-old girl presented to our tertiary care hospital with a complaint of lower extremity weakness and unsteady gait for 2 days. She was able to pull herself to stand, but could not stand unsupported. She had no sensory symptoms or pain. She did not complain of any weakness in her arms, trunk, face, or neck. She h...


    pub_type: 杂志文章


    authors: Chagnon SL,Naik M,Abdel-Hamid H

    更新日期:2014-03-18 00:00:00

  • Calcification of the basal ganglia as a cause of levodopa-resistant parkinsonism.

    abstract::We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, si...


    pub_type: 杂志文章


    authors: Klawans HL,Lupton M,Simon L

    更新日期:1976-03-01 00:00:00

  • Subacute, reversible motor neuron disease.

    abstract::Four patients with a clinical syndrome closely resembling amyotrophic lateral sclerosis recovered completely, without treatment, 5 to 12 months after onset. Electrodiagnostic tests revealed acute and chronic denervation, with normal motor and sensory nerve conduction studies. The CSF was normal, and tests for paraprot...


    pub_type: 杂志文章


    authors: Tucker T,Layzer RB,Miller RG,Chad D

    更新日期:1991-10-01 00:00:00

  • Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy.

    abstract:OBJECTIVE:To report our experience delivering intrathecal nusinersen through cervical puncture in patients with spinal muscular atrophy (SMA) with no lumbar access. BACKGROUND:SMA is a neuromuscular disorder characterized by profound muscle weakness, atrophy, and paralysis due to degeneration of the anterior horn cell...


    pub_type: 杂志文章


    authors: Veerapandiyan A,Pal R,D'Ambrosio S,Young I,Eichinger K,Collins E,Westesson PL,Kwon J,Ciafaloni E

    更新日期:2018-08-14 00:00:00

  • Reduction in voice tremor under thalamic stimulation.

    abstract::We studied the effect of deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus on voice symptoms in seven patients with essential tremor. All had undergone DBS for management of hand tremor. Five of the patients had received unilateral implants; two were treated bilaterally. Each reported improveme...


    pub_type: 临床试验,杂志文章


    authors: Carpenter MA,Pahwa R,Miyawaki KL,Wilkinson SB,Searl JP,Koller WC

    更新日期:1998-03-01 00:00:00

  • Diagnosis of patients presenting to a Huntington disease (HD) clinic without a family history of HD.

    abstract::About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average ...


    pub_type: 杂志文章


    authors: Nance MA,Westphal B,Nugent S

    更新日期:1996-12-01 00:00:00

  • Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects.

    abstract:OBJECTIVE:To determine how memory-encoding tasks elicit functional perfusion change in subjects with amnestic mild cognitive impairment (aMCI). METHODS:Twelve subjects with aMCI and 14 age-matched cognitively normal (CN) subjects were recruited for this study. Arterial spin-labeling perfusion MRI (ASL-MRI) was employe...


    pub_type: 杂志文章


    authors: Xu G,Antuono PG,Jones J,Xu Y,Wu G,Ward D,Li SJ

    更新日期:2007-10-23 00:00:00

  • Regional metabolic correlates of Token test results in cortical and subcortical left hemispheric infarction.

    abstract::We investigated 26 right-handed patients who had aphasia caused by a single infarct in the territory of the left middle cerebral artery (MCA) with cranial CT, positron emission tomography, and a standard language test battery including the Token test. The patients represented an unselected sample of various infarct lo...


    pub_type: 杂志文章


    authors: Karbe H,Herholz K,Szelies B,Pawlik G,Wienhard K,Heiss WD

    更新日期:1989-08-01 00:00:00