Abstract:
:High plasma levels of 3-O-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of disease. It appears unlikely that plasma OMD accumulation contributes to the pathogenesis of wearing-off or on-off responses.
journal_name
Neurologyjournal_title
Neurologyauthors
Fabbrini G,Juncos JL,Mouradian MM,Serrati C,Chase TNdoi
10.1212/wnl.37.5.856subject
Has Abstractpub_date
1987-05-01 00:00:00pages
856-9issue
5eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
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