CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia.

abstract：OBJECTIVE:To describe the diagnosis and management of a 49-year-old woman with multiple sclerosis (MS) developing a progressive hemiparesis and expanding MRI lesion suspicious of progressive multifocal leukoencephalopathy (PML) 19 months after starting natalizumab. RESULTS:Polyomavirus JC (JCV)-specific qPCR in CSF wa...

journal_title：Neurology

authors： Kuhle J,Gosert R,Bühler R,Derfuss T,Sutter R,Yaldizli O,Radue EW,Ryschkewitsch C,Major EO,Kappos L,Frank S,Hirsch HH

更新日期：2011-12-06 00:00:00

abstract：OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...

journal_title：Neurology

authors： Geranmayeh F,Leech R,Wise RJS

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Quantitative head impulse test (HIT) measures the gain of the angular vestibulo-ocular reflex (VOR) during head rotation as the ratio of eye to head acceleration. Bedside HIT identifies subsequent catch-up saccades after the head rotation as indirect signs of VOR deficit. OBJECTIVE:To determine the VOR defi...

journal_title：Neurology

authors： Weber KP,Aw ST,Todd MJ,McGarvie LA,Curthoys IS,Halmagyi GM

更新日期：2008-02-05 00:00:00

abstract：:A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...

journal_title：Neurology

authors： Bruno C,Minetti C,Shanske S,Morreale G,Bado M,Cordone G,DiMauro S

更新日期：1998-01-01 00:00:00

abstract：:Isovaleric acidemia (IVA) is an inborn error of leucine metabolism, resulting in an accumulation of isovaleric acid in the body fluids. The neuropathologic findings in an 11-day-old infant with IVA consisted of diffuse cerebral edema, massive cerebellar hemorrhage, upward transtentorial herniation, and focal degenerat...

journal_title：Neurology

authors： Fischer AQ,Challa VR,Burton BK,McLean WT

更新日期：1981-06-01 00:00:00

abstract：:Five women are presented with a subacute pure pancerebellar syndrome of ataxia and dysarthria to emphasize that this illness may occur without anti-Purkinje-cell or anti-Yo antibodies, or associated systemic cancer. The syndrome evolved over weeks or less and stabilized in four of the patients. Three had had a precedi...

journal_title：Neurology

authors： Ropper AH

更新日期：1993-08-01 00:00:00

abstract：:The authors report results of SPECT cerebral perfusion studies in two patients with familial dysautonomia (FD) during dysautonomic crises and when clinically stable. SPECT imaging studies used 99mTc ethylene cysteine dimer. During dysautonomic crises, regions in the temporoparietal and frontal lobes had increased upta...

journal_title：Neurology

authors： Axelrod FB,Zupanc M,Hilz MJ,Kramer EL

更新日期：2000-07-12 00:00:00

abstract：:The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...

journal_title：Neurology

authors： Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

更新日期：1988-08-01 00:00:00

abstract：:We administered 3 commonly employed tests of mental status (the Information-Memory-Concentration test [IMC], the Mini-Mental State Examination [MMSE], and the Dementia Rating Scale [DRS]) to 92 patients with probable dementia of the Alzheimer type. The 3 tests were readministered to 55 of the patients (2-year subgroup...

journal_title：Neurology

authors： Salmon DP,Thal LJ,Butters N,Heindel WC

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:To describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature. METHODS:Clinical data and radiographic studies on 12 cases from our institution were anal...

journal_title：Neurology

authors： Smith DM,Vossough A,Vorona GA,Beslow LA,Ichord RN,Licht DJ

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of 60 Hz deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 15 consecutive patients with primary dystonia. METHODS:We conducted a retrospective analysis of clinic charts relative to 15 consecutive patients with medically refractory primary dystonia who u...

journal_title：Neurology

authors： Alterman RL,Miravite J,Weisz D,Shils JL,Bressman SB,Tagliati M

更新日期：2007-08-14 00:00:00

abstract：:This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...

journal_title：Neurology

authors： Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jr

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to apply the HIV-associated neurocognitive disorders (HAND) criteria for diagnosing HAND in HIV-infected adults, in a cohort of HIV-infected youth to thus establish whether this system is able to detect a spectrum of neurocognitive disorders (ND) in HIV-infected youth. METHODS:We us...

journal_title：Neurology

authors： Hoare J,Phillips N,Joska JA,Paul R,Donald KA,Stein DJ,Thomas KG

更新日期：2016-07-05 00:00:00

abstract：:In 1810, two British ships, HMS Triumph and HMS Phipps, salvaged a large load of elemental mercury from a wrecked Spanish vessel near Cadiz, Spain. The bladders containing the mercury soon ruptured. The element spread about the ships in liquid and vapor forms. The sailors presented with neurologic compromises: tremor,...

journal_title：Neurology

authors： Doherty MJ

更新日期：2004-03-23 00:00:00

abstract：:Human subjects normally have miniature eye movements during tasks that require steady visual fixation. These eye movements were compared in 12 control subjects and 4 patients with degenerative cerebellar disorders. Slow drifts, small fixation saccades, square waves, saccadic oscillations, flutter, and vertical nystagm...

journal_title：Neurology

authors： Hotson JR

更新日期：1982-01-01 00:00:00

abstract：:Loading doses of 15 to 20 mg per kilogram of both phenobarbital and phenytoin, administered intravenously, are necessary in the newborn to achieve rapid therapeutic plasma anticonvulsant levels. Maintenance doses of 3 to 4 mg per kilogram of both agents will maintain therapeutic levels. Phenytoin is, however, not pred...

journal_title：Neurology

authors： Painter MJ,Pippenger C,Wasterlain C,Barmada M,Pitlick W,Carter G,Abern S

更新日期：1981-09-01 00:00:00

abstract：:The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...

journal_title：Neurology

authors： Osaki Y,Takasawa M,Doi K,Nishimura H,Iwaki T,Imaizumi M,Oku N,Hatazawa J,Kubo T

更新日期：2006-09-12 00:00:00

abstract：BACKGROUND:The paradoxical phenomenon of relative longevity among obese patients with established diseases has been reported for various disease conditions. The authors sought to investigate whether the obesity paradox also applies to intracerebral hemorrhage (ICH) survivors. METHODS:A total of 1,604 patients with ICH...

journal_title：Neurology

authors： Kim BJ,Lee SH,Ryu WS,Kim CK,Lee J,Yoon BW

更新日期：2011-02-08 00:00:00

abstract：OBJECTIVE:To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS:After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cogn...

journal_title：Neurology

authors： Godefroy O,Yaïche H,Taillia H,Bompaire F,Nédélec-Ciceri C,Bonnin C,Varvat J,Vincent-Grangette F,Diouf M,Mas JL,Canaple S,Lamy C,Arnoux A,Leclercq C,Tasseel-Ponche S,Roussel M,Barbay M,GRECogVASC Study Group.

更新日期：2018-11-20 00:00:00

abstract：:We present a case of uncontrolled temporal lobe epilepsy due to a focal left temporal neuronal heterotopia associated with the nevoid-basal-cell carcinoma syndrome. This is the first pathologically described lesion associated with temporal lobe epilepsy in this syndrome. Because the patient's seizures resolved after a...

journal_title：Neurology

authors： Hogan RE,Tress B,Gonzales MF,King JO,Cook MJ

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To assess functional changes in lymphocyte repertoire and subsequent clinical implications during delayed-release dimethyl fumarate (DMF) treatment in patients with multiple sclerosis. METHODS:Using peripheral blood from several clinical trials of DMF, immune cell subsets were quantified using flow cytometry...

journal_title：Neurology

authors： Mehta D,Miller C,Arnold DL,Bame E,Bar-Or A,Gold R,Hanna J,Kappos L,Liu S,Matta A,Phillips JT,Robertson D,von Hehn CA,Campbell J,Spach K,Yang L,Fox RJ

更新日期：2019-04-09 00:00:00

abstract：OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, pap...

journal_title：Neurology

authors： Kupersmith MJ,Gamell L,Turbin R,Peck V,Spiegel P,Wall M

更新日期：1998-04-01 00:00:00

abstract：:We report a Japanese Becker muscular dystrophy (BMD) patient with occasional myalgia and cramps during normal activity that developed at the age of 28 months. His family history was negative for neuromuscular diseases. Muscle biopsy analyses, including dystrophin immunostaining, disclosed no clinically relevant findin...

journal_title：Neurology

authors： Ishigaki C,Patria SY,Nishio H,Yabe M,Matsuo M

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:We describe a novel congenital motor neuron disease with early demise due to respiratory insufficiency with clinical overlap with spinal muscular atrophy with respiratory distress (SMARD) type 1 but lacking a mutation in the IGHMBP2 gene. METHODS:Exome sequencing was used to identify a de novo mutation in th...

journal_title：Neurology

authors： Butterfield RJ,Stevenson TJ,Xing L,Newcomb TM,Nelson B,Zeng W,Li X,Lu HM,Lu H,Farwell Gonzalez KD,Wei JP,Chao EC,Prior TW,Snyder PJ,Bonkowsky JL,Swoboda KJ

更新日期：2014-04-15 00:00:00

abstract：OBJECTIVE:To investigate the role of blocking antibodies in neonatal Guillain-Barré syndrome (GBS) occurring 12 days postpartum in a child born to a mother with ongoing GBS. METHODS:We studied plasma filtrate, purified IgG, and monovalent Fab fragments from the affected mother and serum from the neonate as well as ser...

journal_title：Neurology

authors： Buchwald B,de Baets M,Luijckx GJ,Toyka KV

更新日期：1999-10-12 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...

journal_title：Neurology

authors： Lochmüller H,Behin A,Caraco Y,Lau H,Mirabella M,Tournev I,Tarnopolsky M,Pogoryelova O,Woods C,Lai A,Shah J,Koutsoukos T,Skrinar A,Mansbach H,Kakkis E,Mozaffar T

更新日期：2019-04-30 00:00:00

abstract：:A patient presented with bilateral brachial plexus neuropathy which 2 weeks later evolved into a polyneuropathy involving all four extremities. On further investigation, the patient was found to have systemic lupus erythematosus. Treatment with steroids was accompanied by complete resolution of the neurologic findings...

journal_title：Neurology

authors： Bloch SL,Jarrett MP,Swerdlow M,Grayzel AI

更新日期：1979-12-01 00:00:00

abstract：:Migraine is a frequent familial disorder that, in common with most multifactorial disorders, has an unknown etiology. The authors identified several families with multiple individuals affected by typical migraine using a single set of diagnostic criteria and studied these families for cosegregation between the disorde...

journal_title：Neurology

authors： Nyholt DR,Lea RA,Goadsby PJ,Brimage PJ,Griffiths LR

更新日期：1998-05-01 00:00:00

abstract：:Weight loss is common in Alzheimer's disease (AD), but its pathogenesis is poorly understood. It is unclear whether an elevated daily energy expenditure contributes to the weight loss. We tested the hypothesis that daily energy expenditure is higher in AD patients compared to healthy elderly. Thirty AD (73 +/- 8 years...

journal_title：Neurology

authors： Poehlman ET,Toth MJ,Goran MI,Carpenter WH,Newhouse P,Rosen CJ

更新日期：1997-04-01 00:00:00

abstract：:Calcification in brainstem gliomas is an unusual histologic and and radiologic finding. To date, radiologic evidence of calcification in these tumors has not been reported. The two patients described here had evidence of calcification on either computerized tomography (CT) or plain skull films. Increasing availability...

journal_title：Neurology

authors： Duffner PK,Klein DM,Cohen ME

更新日期：1978-08-01 00:00:00