Intra-blood-brain barrier synthesis of IgG: comparison of IgG synthesis formulas in a computer model and in 1,629 consecutive specimens.

abstract：OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...

journal_title：Neurology

authors： Josephs KA,Duffy JR,Strand EA,Machulda MM,Senjem ML,Lowe VJ,Jack CR Jr,Whitwell JL

更新日期：2013-07-23 00:00:00

abstract：:The clinical and angiographic correlations of small deep infarcts seen on computed tomography (CT) scan were studied in 297 consecutive patients. Some of these showed the features described by Fisher as part of the lacunar syndrome. In a large number, a source of emboli from either a cardiac or a carotid source was hi...

journal_title：Neurology

authors： Pullicino P,Nelson RF,Kendall BE,Marshall J

更新日期：1980-10-01 00:00:00

abstract：:There was a report of spongiform encephalopathy transmitted to Syrian hamsters by intracerebral inoculation with the blood buffy coat of patients with Alzheimer's disease (AD) and their unaffected first-degree relatives. We attempted to verify that report, taking measures to reduce the risk of contaminating samples wi...

journal_title：Neurology

authors： Godec MS,Asher DM,Kozachuk WE,Masters CL,Rubi JU,Payne JA,Rubi-Villa DJ,Wagner EE,Rapoport SI,Schapiro MB

更新日期：1994-06-01 00:00:00

abstract：:Using a crossed-response task, monkeys with neglect induced by frontal lesions appear to have motor rather than sensory neglect. However, the crossed-response task may not reveal sensory neglect (inattention) if no perceptual discrimination is required. We therefore trained two monkeys in a perceptually complex crosse...

journal_title：Neurology

authors： Heilman KM,Valenstein E,Day A,Watson R

更新日期：1995-06-01 00:00:00

abstract：:A median safinamide (SAF) dose of 70 mg/day (range 40 to 90 mg/day) increased the percentage of parkinsonian patients improving their motor scores by > or =30% from baseline (responders) after 3 months from 21.4% (placebo) to 37.5% (p < 0.05, calculated by logistic regression analysis). In a subgroup of 101 patients u...

journal_title：Neurology

authors： Stocchi F,Arnold G,Onofrj M,Kwiecinski H,Szczudlik A,Thomas A,Bonuccelli U,Van Dijk A,Cattaneo C,Sala P,Fariello RG,Safinamide Parkinson's Study Group.

更新日期：2004-08-24 00:00:00

abstract：OBJECTIVE:To assess the correlation of tissue parameters estimated by quantitative magnetic resonance (MR) techniques and motor handicap in patients with hypomyelination. METHODS:Twenty-eight patients with different causes of hypomyelination (12 males, 16 females; mean age 10 years) and 61 controls (33 males, 28 femal...

journal_title：Neurology

authors： Steenweg ME,Wolf NI,van Wieringen WN,Barkhof F,van der Knaap MS,Pouwels PJ

更新日期：2016-08-23 00:00:00

abstract：:A 47-year-old woman had myasthenia gravis with only moderate weakness and a consistently poor response to anticholinesterase medication. She was investigated with routine electrophysiologic studies and single-fiber electromyography. The studies showed a limited effect of anticholinesterase medication. There was a decr...

journal_title：Neurology

authors： Schwartz MS,Stålberg E

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks. METHODS:We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis ...

journal_title：Neurology

authors： Bernhardt BC,Fadaie F,Liu M,Caldairou B,Gu S,Jefferies E,Smallwood J,Bassett DS,Bernasconi A,Bernasconi N

更新日期：2019-05-07 00:00:00

abstract：:Proteins from single frozen sections of human muscle were separated by two-dimensional gel electrophoresis and detected by fluorography or Coomassie Blue staining. The major proteins were identical in different normal muscles obtained from either sex at different ages, and in Duchenne and myotonic dystrophy samples. C...

journal_title：Neurology

authors： Giometti CS,Danon MJ,Anderson NG

更新日期：1983-09-01 00:00:00

abstract：OBJECTIVE:To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors. METHODS:Patients with definite MS, onset prior to July 1988, registered with a BCMS clinic before July 1998, with at least one E...

journal_title：Neurology

authors： Tremlett H,Devonshire V

更新日期：2006-09-26 00:00:00

abstract：:This review summarizes evidence, primarily from recent human studies, indirectly supporting a novel hypothesis: that the assessment of healthy individuals' responses to standardized noxious stimuli in a controlled laboratory environment has important implications for the later risk of developing a broad spectrum of ch...

journal_title：Neurology

authors： Edwards RR

更新日期：2005-08-09 00:00:00

abstract：:PET-demonstrated decreases in [11C]flumazenil binding occur in anterior mesial temporal structures on the side of epileptogenesis in unilateral mesial temporal lobe epilepsy. We performed quantitative autoradiography on anterior mesial and lateral temporal specimens from 11 subjects with unilateral mesial temporal lob...

journal_title：Neurology

authors： Burdette DE,Sakurai SY,Henry TR,Ross DA,Pennell PB,Frey KA,Sackellares JC,Albin RL

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT). With a focus on Singapore, this analysis identifies circumstances in which ge...

journal_title：Neurology

authors： Dong D,Sung C,Finkelstein EA

更新日期：2012-09-18 00:00:00

abstract：:Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor. ...

journal_title：Neurology

authors： Sabra AF,Hallett M,Sudarsky L,Mullally W

更新日期：1982-08-01 00:00:00

abstract：:A 48-year-old woman became totally deaf after a head injury. Magnetic resonance imaging showed bilateral contusions around the inferior colliculi and the brainstem auditory evoked potentials (BAEP) failed to show any abnormality. This case demonstrates that small, symmetrical, bilateral lesions around the inferior col...

journal_title：Neurology

authors： Hu CJ,Chan KY,Lin TJ,Hsiao SH,Chang YM,Sung SM

更新日期：1997-05-01 00:00:00

abstract：:In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...

journal_title：Neurology

authors： Bernad PG,Szyfelbein WM,Weiss HD,Richardson EP Jr

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To address the role of cell death regulatory genes of the bcl-2 and caspase families in the neuropathology of human epilepsy using tissue extracted from patients undergoing temporal lobectomy for intractable seizures. METHODS:Using Western blotting and immunohistochemistry, the authors investigated the expre...

journal_title：Neurology

authors： Henshall DC,Clark RS,Adelson PD,Chen M,Watkins SC,Simon RP

更新日期：2000-07-25 00:00:00

abstract：OBJECTIVE:To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS:We prospectively collected clinical and demographic data from 116 symptomatic C9ALS and 12 non-amyotrophic lateral sclerosis (ALS) f...

journal_title：Neurology

authors： Cammack AJ,Atassi N,Hyman T,van den Berg LH,Harms M,Baloh RH,Brown RH,van Es MA,Veldink JH,de Vries BS,Rothstein JD,Drain C,Jockel-Balsarotti J,Malcolm A,Boodram S,Salter A,Wightman N,Yu H,Sherman AV,Esparza TJ,Mc

更新日期：2019-10-22 00:00:00

abstract：OBJECTIVE:This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS:A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were en...

journal_title：Neurology

authors： Meng R,Asmaro K,Meng L,Liu Y,Ma C,Xi C,Li G,Ren C,Luo Y,Ling F,Jia J,Hua Y,Wang X,Ding Y,Lo EH,Ji X

更新日期：2012-10-30 00:00:00

abstract：:Confusion, speech arrest, automatic behavior, and amnesia characterize the prolonged twilight states of both petit mal and psychomotor status. However, in psychomotor status two electroclinical phases were differentiated: (1) A continuous twilight state with partial responsiveness and reactive automatisms interrupted ...

journal_title：Neurology

authors： Belafsky MA,Rosman NP,Miller P,Waddell G,Boxley-Johnson J,Delgado-Escueta AV

更新日期：1978-03-01 00:00:00

abstract：OBJECTIVE:To determine the rate of progression of mild cognitive impairment (MCI) to dementia with Lewy bodies (DLB). METHODS:We followed 337 patients with MCI in the Mayo Alzheimer's Disease Research Center (range 2-12 years). Competing risks survival models were used to examine the rates of progression to clinically...

journal_title：Neurology

authors： Ferman TJ,Smith GE,Kantarci K,Boeve BF,Pankratz VS,Dickson DW,Graff-Radford NR,Wszolek Z,Van Gerpen J,Uitti R,Pedraza O,Murray ME,Aakre J,Parisi J,Knopman DS,Petersen RC

更新日期：2013-12-03 00:00:00

abstract：:We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...

journal_title：Neurology

authors： Valls-Sole J,Tolosa ES

更新日期：1989-08-01 00:00:00

abstract：:The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...

journal_title：Neurology

authors： Carpenter S,Karpati G,Rothman S,Watters G

更新日期：1976-10-01 00:00:00

abstract：:The intracarotid amobarbital test (IAT) is used to lateralize language function and assess hemispheric memory. In this study 23 non-lesional epileptic patients were evaluated. The magnitude of the difference in IAT scores between the two hemispheres was significantly greater in the patients whose seizures lateralized ...

journal_title：Neurology

authors： Swearer JM,Kane KJ,Phillips CA,Weaver JP,Anderson TD,Lavoie MS

更新日期：1999-01-15 00:00:00

abstract：OBJECTIVES:To examine whether preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) influenced 30-day stroke mortality. METHODS:We conducted a nationwide population-based cohort study. Using medical databases, we identified all first-time stroke hospitalizations in Denmark between 2004 and 2012 ...

journal_title：Neurology

authors： Schmidt M,Hováth-Puhó E,Christiansen CF,Petersen KL,Bøtker HE,Sørensen HT

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:New immigrants to North America, most of whom are under age 50 years, exhibit fewer risk factors for cardiovascular disease than their native-born counterparts, yet the stress of resettlement may conceivably place them at higher risk of stroke. We determined the risk of acute stroke associated with recency o...

journal_title：Neurology

authors： Saposnik G,Redelmeier DA,Lu H,Lonn E,Fuller-Thomson E,Ray JG

更新日期：2010-02-09 00:00:00

abstract：OBJECTIVE:To test the hypothesis that accelerated peripheral blood mononuclear cell recovery after alemtuzumab treatment of multiple sclerosis is associated with recurrent disease activity and to investigate the claim that CD4 counts greater than 388.5 × 10(6) cells/mL at 12 months can be used to identify patients who ...

journal_title：Neurology

authors： Kousin-Ezewu O,Azzopardi L,Parker RA,Tuohy O,Compston A,Coles A,Jones J

更新日期：2014-06-17 00:00:00

abstract：:The clinical and radiologic impact of developing neutralizing antibodies (NAbs) to interferon beta (IFNbeta) while on this therapy for multiple sclerosis (MS) is assessed. On the basis of Class II and III evidence, it is concluded that treatment of patients with MS with IFNbeta (Avonex, Betaseron, or Rebif) is associa...

journal_title：Neurology

authors： Goodin DS,Frohman EM,Hurwitz B,O'Connor PW,Oger JJ,Reder AT,Stevens JC

更新日期：2007-03-27 00:00:00

abstract：BACKGROUND:Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication. These studies concluded that epilepsy does not inevitably lead to global cerebral damag...

journal_title：Neurology

authors： Bernhardt BC,Worsley KJ,Kim H,Evans AC,Bernasconi A,Bernasconi N

更新日期：2009-05-19 00:00:00

abstract：:Four adolescents had basilar migraine, infrequent cerebral seizures, and severe EEG abnormalities. The clinical course was benign, with normal personality, mentation, and neurologic examination. Almost continuous EEG abnormalities, consisting of rhythmic temporo-occipital sharp and slow wave discharges, or generalized...

journal_title：Neurology

authors： Camfield PR,Metrakos K,Andermann F

更新日期：1978-06-01 00:00:00