Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy.

abstract：:Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...

journal_title：Neurology

authors： Futrell N,Schultz LR,Millikan C

更新日期：1992-09-01 00:00:00

abstract：:Azathioprine has the longest continuing history of clinical use in the treatment of multiple sclerosis (MS) of any immunosuppressive therapy besides corticosteroids. To date, 19 clinical trials of azathioprine in MS have been reported, and another eight are under way. A review of the reported trials indicates little e...

journal_title：Neurology

authors： Silberberg DH

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF). METHODS:NF1 experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors usin...

journal_title：Neurology

authors： Ortonne N,Wolkenstein P,Blakeley JO,Korf B,Plotkin SR,Riccardi VM,Miller DC,Huson S,Peltonen J,Rosenberg A,Carroll SL,Verma SK,Mautner V,Upadhyaya M,Stemmer-Rachamimov A

更新日期：2018-07-10 00:00:00

abstract：OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...

journal_title：Neurology

authors： Jones LK Jr,Eggers SDZ,Capobianco DJ,Boes CJ

更新日期：2018-10-16 00:00:00

abstract：OBJECTIVE:To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS:Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BD...

journal_title：Neurology

authors： Rossi S,Studer V,Motta C,Polidoro S,Perugini J,Macchiarulo G,Giovannetti AM,Pareja-Gutierrez L,Calò A,Colonna I,Furlan R,Martino G,Centonze D

更新日期：2017-09-26 00:00:00

abstract：OBJECTIVE:Since Alzheimer disease (AD) is a slowly progressive disorder and its pathologic features are likely to be present for many years before symptoms become manifest, we investigated whether microstructural white matter changes similar to those identified in patients with AD can be detected in cognitively normal ...

journal_title：Neurology

authors： Zhuang L,Sachdev PS,Trollor JN,Kochan NA,Reppermund S,Brodaty H,Wen W

更新日期：2012-08-21 00:00:00

abstract：:In children, seizures associated with status epilepticus (SE) include a number of types that are age-related. These types of seizures are not associated with SE in older patients. Likewise, etiologies of SE in children are also unique to this patient population, in particular those responsible for SE in the neonate. C...

journal_title：Neurology

authors： Lockman LA

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To determine whether groups of surrogates for patients with severe acute brain injury (SABI) with poor prognosis can be identified based on their prioritization of goals-of-care (GOC) decisional concerns, an online survey of 1,588 adults recruited via a probability-based panel representative of the US populat...

journal_title：Neurology

authors： Hwang DY,Knies AK,Mampre D,Kolenikov S,Schalk M,Hammer H,White DB,Holloway RG,Sheth KN,Fraenkel L

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Abnormal insulin metabolism may contribute to the clinical symptoms and pathophysiology of AD. In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden. METHODS:On separate mornings, 16 healthy older ad...

journal_title：Neurology

authors： Watson GS,Peskind ER,Asthana S,Purganan K,Wait C,Chapman D,Schwartz MW,Plymate S,Craft S

更新日期：2003-06-24 00:00:00

abstract：:Hemorrhage complicating acute carbon monoxide poisoning is usually confined to the basal ganglia. The authors report three people with acute carbon monoxide poisoning manifesting selective or prominent white matter involvement complicated by hemorrhagic infarction on CT and MRI in one and by subcortical T2*-weighted M...

journal_title：Neurology

authors： Finelli PF,DiMario FJ Jr

更新日期：2004-09-28 00:00:00

abstract：:Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients w...

journal_title：Neurology

authors： Noskin O,Jafarimojarrad E,Libman RB,Nelson JL

更新日期：2006-07-11 00:00:00

abstract：:We report a patient with striatonigral degeneration in whom T2-weighted MRI imaging revealed low signal and atrophy in the putamen. Neuropathologic studies confirmed putaminal atrophy and iron deposition in the MRI low signal regions. ...

journal_title：Neurology

authors： O'Brien C,Sung JH,McGeachie RE,Lee MC

更新日期：1990-04-01 00:00:00

abstract：:About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...

journal_title：Neurology

authors： Hart RG,Gardner DP,Howieson J

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVES:Compensatory processes involving the recruitment of additional cerebral areas can limit cognitive impairment caused by brain damage as revealed by fMRI. Multiple sclerosis (MS) is characterized by frequent cognitive deficiencies and diffuse brain damage. Understanding the missing or disturbed processes resul...

journal_title：Neurology

authors： Bonnet MC,Allard M,Dilharreguy B,Deloire M,Petry KG,Brochet B

更新日期：2010-10-05 00:00:00

abstract：:We studied 96 Chinese patients with TIAs using transcranial Doppler and duplex ultrasonography. We found intracranial stenosis or occlusion in 51% of cases and extracranial disease in 19% of cases. The most common intracranial lesion was stenosis of the terminal internal carotid artery or proximal middle cerebral arte...

journal_title：Neurology

authors： Huang YN,Gao S,Li SW,Huang Y,Li JF,Wong KS,Kay R

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between baseline hypertension and severity of white matter hyperintensities (WMH) at 4-year follow-up in a sample of subjects aged 59 to 71 years old at entry. METHODS:Subjects were participants in the Epidemiology of Vascular Ageing study, a longitudinal study on vascular agi...

journal_title：Neurology

authors： Dufouil C,de Kersaint-Gilly A,Besançon V,Levy C,Auffray E,Brunnereau L,Alpérovitch A,Tzourio C

更新日期：2001-04-10 00:00:00

abstract：OBJECTIVES:To estimate patient-acceptable symptom state (PASS) cut points for myasthenia gravis (MG) health scales. METHODS:We conducted an electronic survey that included the Myasthenia Gravis Impairment Index (MGII), EuroQol 5-Dimension (EQ5D), and a simple PASS question. PASS-anchored thresholds were estimated for ...

journal_title：Neurology

authors： Mendoza M,Tran C,Bril V,Katzberg HD,Barnett C

更新日期：2020-09-22 00:00:00

abstract：:We investigated the effects of estrogen replacement therapy (ERT) on the risk of development of dementia in 87 women with Parkinson's disease without dementia (PDND), 80 women with Parkinson's disease with dementia (PDD), and 989 nondemented healthy women from the same community. ERT was protective for the development...

journal_title：Neurology

authors： Marder K,Tang MX,Alfaro B,Mejia H,Cote L,Jacobs D,Stern Y,Sano M,Mayeux R

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent p...

journal_title：Neurology

authors： Raja Rayan DL,Haworth A,Sud R,Matthews E,Fialho D,Burge J,Portaro S,Schorge S,Tuin K,Lunt P,McEntagart M,Toscano A,Davis MB,Hanna MG

更新日期：2012-06-12 00:00:00

abstract：:Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism i...

journal_title：Neurology

authors： Portman AT,Giladi N,Leenders KL,Maguire P,Veenma-van der Duin L,Swart J,Pruim J,Simon ES,Hassin-Baer S,Korczyn AD

更新日期：2001-06-26 00:00:00

abstract：:A 57-year-old chronically immunosuppressed woman with systemic lupus erythematosus developed fulminant meningoencephalitis due to Acanthamoeba castellanii. Amebic trophozoites were also found in the lungs, suggesting a primary pulmonary focus of infection. This case illustrates that Acanthamoeba can cause a fulminant,...

journal_title：Neurology

authors： Grunnet ML,Cannon GH,Kushner JP

更新日期：1981-02-01 00:00:00

abstract：:We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...

journal_title：Neurology

authors： Smith D,Lucas S,Jacewicz M

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:To assess alterations in brain metabolites of patients with Pelizaeus-Merzbacher disease (PMD) with the proteolipid protein gene 1 (PLP1) duplications using quantitative proton MRS. METHODS:Five unrelated male Japanese patients with PMD with PLP1 duplications were analyzed using automated proton brain examin...

journal_title：Neurology

authors： Takanashi J,Inoue K,Tomita M,Kurihara A,Morita F,Ikehira H,Tanada S,Yoshitome E,Kohno Y

更新日期：2002-01-22 00:00:00

abstract：OBJECTIVE:To determine whether congenital arhinia/Bosma arhinia microphthalmia syndrome (BAMS) and facioscapulohumeral muscular dystrophy type 2 (FSHD2), 2 seemingly unrelated disorders both caused by heterozygous pathogenic missense variants in the SMCHD1 gene, might represent different ends of a broad single phenotyp...

journal_title：Neurology

authors： Mul K,Lemmers RJLF,Kriek M,van der Vliet PJ,van den Boogaard ML,Badrising UA,Graham JM Jr,Lin AE,Brand H,Moore SA,Johnson K,Evangelista T,Töpf A,Straub V,Kapetanovic García S,Sacconi S,Tawil R,Tapscott SJ,Voermans NC

更新日期：2018-08-07 00:00:00

abstract：:Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...

journal_title：Neurology

authors： Friedman JH,Ambler M

更新日期：1992-09-01 00:00:00

abstract：:Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (s...

journal_title：Neurology

authors： Rinker JR 2nd,Trinkaus K,Cross AH

更新日期：2006-10-10 00:00:00

abstract：:We previously compared the diagnostic capabilities of MRI of the head with CT, evoked potentials, and CSF oligoclonal banding (OB) analysis in a prospective evaluation of 200 patients with suspected multiple sclerosis (MS). To examine the ability of MRI and other paraclinical tests to predict the diagnosis of clinical...

journal_title：Neurology

authors： Lee KH,Hashimoto SA,Hooge JP,Kastrukoff LF,Oger JJ,Li DK,Paty DW

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:In a previous study, the authors found that the risk of AD among mothers who were 35 years or younger when their children with Down syndrome (DS) were born was five times that of mothers of children with other forms of mental retardation. The current study investigated the specificity of the familial aggrega...

journal_title：Neurology

authors： Schupf N,Kapell D,Nightingale B,Lee JH,Mohlenhoff J,Bewley S,Ottman R,Mayeux R

更新日期：2001-09-25 00:00:00

abstract：:Supporting young people with pediatric multiple sclerosis can be challenging for families and health care providers. Adolescents may be more resilient than adults in reaction to the diagnosis but can have more difficulty planning for their futures. Appropriate, sensitive, and focused health provision should include co...

journal_title：Neurology

authors： Krupp LB,Rintell D,Charvet LE,Milazzo M,Wassmer E

更新日期：2016-08-30 00:00:00

abstract：:We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...

journal_title：Neurology

authors： Azulay JP,Blin O,Pouget J,Boucraut J,Billé-Turc F,Carles G,Serratrice G

更新日期：1994-03-01 00:00:00