Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis.

abstract：:The intensive study of seizures via serial 24-hour EEG-video monitoring has allowed enhanced observation of sleep patterns among epilepsy patients and has revealed that disturbed rest is common in this population. Previous work has shown that sleep deprivation of any type can exacerbate seizure activity, leading to sp...

journal_title：Neurology

authors： Sammaritano M,Sherwin A

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To track cognitive and language changes over time in patients with logopenic (lv-PPA) and semantic (sv-PPA) variants of primary progressive aphasia (PPA). METHODS:Thirteen consecutive patients with lv-PPA and 11 patients with sv-PPA underwent yearly evaluation for a mean of 3 years. Nineteen patients (11 lv-...

journal_title：Neurology

authors： Leyton CE,Hsieh S,Mioshi E,Hodges JR

更新日期：2013-03-05 00:00:00

abstract：OBJECTIVE:To investigate the association of triglyceride (TG) principal component scores with Alzheimer disease (AD) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (A/T/N/V) biomarkers for AD. METHODS:Serum levels of 84 TG species were measured with untargeted lipid profiling of 689 participants ...

journal_title：Neurology

authors： Bernath MM,Bhattacharyya S,Nho K,Barupal DK,Fiehn O,Baillie R,Risacher SL,Arnold M,Jacobson T,Trojanowski JQ,Shaw LM,Weiner MW,Doraiswamy PM,Kaddurah-Daouk R,Saykin AJ,Alzheimer's Disease Neuroimaging Initiative and Alzheim

更新日期：2020-05-19 00:00:00

abstract：:A model of latent infection by varicella-zoster virus (VZV) was obtained in the adult rat. Inoculation of VZV-infected cells in the skin led to infection of the peripheral nervous system. Latency was characterized by a long-lasting presence of the viral genome, of selected viral gene transcripts, and of at least one v...

journal_title：Neurology

authors： Sadzot-Delvaux C,Debrus S,Nikkels A,Piette J,Rentier B

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:To prospectively evaluate the effect of pump-infused intrathecal baclofen infusion (ITB) in therapeutic doses on sleep quality and on daytime and nighttime respiratory function in patients with severe spasticity. METHODS:We prospectively evaluated 20 consecutive patients (mean +/- SD age 45 +/- 13 years). We...

journal_title：Neurology

authors： Bensmail D,Quera Salva MA,Roche N,Benyahia S,Bohic M,Denys P,Bussel B,Lofaso F

更新日期：2006-10-24 00:00:00

abstract：:The defect occurring when a patient fails to report a visual stimulus presented in a visual half-field may be attributed to hemianopia (deafferentation) caused by a geniculocalcarine lesion. However, failure to report a stimulus presented in a visual field may also be caused by hemispatial visual inattention. We repor...

journal_title：Neurology

authors： Kooistra CA,Heilman KM

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVE:To undertake an effectiveness and safety analysis of EVT in patients with LVO and NIH Stroke Scale (NIHSS) score ≤6 using datasets of multicenter and multinational nature. METHODS:We pooled patients with anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presen...

journal_title：Neurology

authors： Volny O,Zerna C,Tomek A,Bar M,Rocek M,Padr R,Cihlar F,Nevsimalova M,Jurak L,Havlicek R,Kovar M,Sevcik P,Rohan V,Fiksa J,Cernik D,Jura R,Vaclavik D,Cimflova P,Puig J,Dowlatshahi D,Khaw AV,Fainardi E,Najm M,De

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVE:To analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective neuropsychologic tests, and sleep findings. METHODS:Data collection included comprehensive clinical investigation, study of ...

journal_title：Neurology

authors： Huang YS,Hsiao IT,Liu FY,Hwang FM,Lin KL,Huang WC,Guilleminault C

更新日期：2018-04-24 00:00:00

abstract：OBJECTIVE:To determine the effect of injections of botulinum toxin on simple motor tics. BACKGROUND:Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin. METHODS:Patients with suitable simple motor tics were randomized to receive botulinum toxin an...

journal_title：Neurology

authors： Marras C,Andrews D,Sime E,Lang AE

更新日期：2001-03-13 00:00:00

abstract：OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...

journal_title：Neurology

authors： Bjornestad A,Tysnes OB,Larsen JP,Alves G

更新日期：2016-10-11 00:00:00

abstract：:Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...

journal_title：Neurology

authors： Ravits J,Hallett M,Baker M,Wilkins D

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:To determine whether blood-based biomarkers can differentiate older veterans with and without traumatic brain injury (TBI) and cognitive impairment (CogI). METHODS:We enrolled 155 veterans from 2 veterans' retirement homes: 90 without TBI and 65 with TBI history. Participants were further separated into CogI...

journal_title：Neurology

authors： Peltz CB,Kenney K,Gill J,Diaz-Arrastia R,Gardner RC,Yaffe K

更新日期：2020-09-01 00:00:00

abstract：:We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...

journal_title：Neurology

authors： Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

更新日期：1983-05-01 00:00:00

abstract：OBJECTIVE:To investigate if patterns of CSF biomarkers (T-tau, P-tau, and Abeta42) can predict cognitive progression, outcome of cholinesterase inhibitor (ChEI) treatment, and mortality in Alzheimer disease (AD). METHODS:We included outpatients with AD (n = 151) from a prospective treatment study with ChEI. At baselin...

journal_title：Neurology

authors： Wallin AK,Blennow K,Zetterberg H,Londos E,Minthon L,Hansson O

更新日期：2010-05-11 00:00:00

abstract：OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...

journal_title：Neurology

authors： Jones LK Jr,Eggers SDZ,Capobianco DJ,Boes CJ

更新日期：2018-10-16 00:00:00

abstract：:When the WHO's Topic Advisory Group for Neurology (TAG) started work on revision of the ICD-10 diagnostic codes in June 2009, the issues were daunting. The existing classification was produced a generation ago and the need to move to the digital age was becoming imperative. Appreciating modern advances in genetics and...

journal_title：Neurology

authors： Shakir R,Bergen D

更新日期：2013-07-09 00:00:00

abstract：OBJECTIVE:To characterize patterns of cognitive functioning in a well-defined group of patients with MRI-identified coexisting left temporal lobe developmental malformations (TLDM) and mesial temporal sclerosis (MTS), and to examine neuropsychological outcome in this dual-pathology group following epilepsy surgery. ME...

journal_title：Neurology

authors： Martin R,Dowler R,Gilliam F,Faught E,Morawetz R,Kuzniecky R

更新日期：1999-09-11 00:00:00

abstract：OBJECTIVE:To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire. METHODS:In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual...

journal_title：Neurology

authors： Borm CDJM,Visser F,Werkmann M,de Graaf D,Putz D,Seppi K,Poewe W,Vlaar AMM,Hoyng C,Bloem BR,Theelen T,de Vries NM

更新日期：2020-04-07 00:00:00

abstract：OBJECTIVE:To examine associations of average and change in late-life blood pressure (BP) with cerebrovascular and Alzheimer disease (AD) neuropathology in a large group of decedents followed longitudinally in vivo. METHODS:This clinical-pathologic study was derived from prospective, community-based cohort studies of a...

journal_title：Neurology

authors： Arvanitakis Z,Capuano AW,Lamar M,Shah RC,Barnes LL,Bennett DA,Schneider JA

更新日期：2018-08-07 00:00:00

abstract：:Pramipexole is a new, selective, nonergoline dopamine agonist that acts on D2 and preferentially on D3 dopamine receptors. Phase II and III clinical trials have shown this drug to be useful in treating both early and advanced Parkinson's disease (PD) patients. A double-blind, randomized, multicenter study was performe...

journal_title：Neurology

authors： Guttman M

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVES:To examine the illusional sensation of movement evoked by vibration of an immobilized arm. METHODS:Patients with idiopathic focal dystonia were compared with those with idiopathic PD and with patients with dystonia secondary to PD. A 100-Hz transcutaneous vibratory stimulus was applied to the biceps brachii...

journal_title：Neurology

authors： Rome S,Grünewald RA

更新日期：1999-11-10 00:00:00

abstract：:Permanent paralysis was induced in dogs by a 500 gram centimeter force injury on the spinal cord, and drug treatments were given 1 hour after injury and were continued for 3 days. Dogs were evaluated for 90 days. Isotonic saline or mannitol administration were ineffective in reversing the paralysis. In dogs receiving ...

journal_title：Neurology

authors： De La Torre JC,Johnson CM,Goode DJ,Mullan S

更新日期：1975-06-01 00:00:00

abstract：:We studied 10 patients with transient global amnesia (TGA). Routine electroencephalograms (EEGs) were normal in six; two showed mild temporal lobe abnormalities, one had bitemporal delta activity with rare sharp waves, and one showed bioccipital rhythmic theta activity. Nasopharyngeal (NP) recordings were obtained in ...

journal_title：Neurology

authors： Rowan AJ,Protass LM

更新日期：1979-06-01 00:00:00

abstract：:We report imaging and clinical findings of leukoencephalopathy occurring after levamisole. The lesions were hypoattenuating on CT and appeared as multifocal oval or elliptical foci in the white matter or along the subependymal veins on MRI. Most lesions resolve after prompt withdrawal of levamisole. Detailed history t...

journal_title：Neurology

authors： Liu HM,Hsieh WJ,Yang CC,Wu VC,Wu KD

更新日期：2006-09-26 00:00:00

abstract：:Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor activity, worsen at rest, have a circadian peak in expression in the evening and at night, and can severely disrupt sleep. Primary treatment is directed at CNS dopaminergic systems, particularly activation of D(2)-like (D(2), D(3),...

journal_title：Neurology

authors： Clemens S,Rye D,Hochman S

更新日期：2006-07-11 00:00:00

abstract：:The authors describe the outcome of five patients with a cardiac thrombus selected among 183 patients with stroke (2.7 %) who were given IV tissue plasminogen activator (tPA). No early systemic or cerebral embolism occurred. Two patients made a complete recovery at 3 months. Two patients had a moderate outcome. One pa...

journal_title：Neurology

authors： Derex L,Nighoghossian N,Perinetti M,Honnorat J,Trouillas P

更新日期：2001-12-11 00:00:00

abstract：OBJECTIVE:To determine the clinical value of JC virus (JCV) detection in various anatomic compartments for the diagnosis of progressive multifocal leukoencephalopathy (PML). METHODS:CSF, peripheral blood mononuclear cells (PBMC), plasma, and urine samples were evaluated from HIV-infected and uninfected individuals. JC...

journal_title：Neurology

authors： Koralnik IJ,Boden D,Mai VX,Lord CI,Letvin NL

更新日期：1999-01-15 00:00:00

abstract：:Spinocerebellar ataxia type 6 (SCA6) is a newly classified autosomal-dominant cerebellar ataxia (ADCA) associated with CAG repeat expansion. We screened 111 patients with cerebellar ataxia for the SCA6 mutation. Of these, 35 patients were found to have expanded CAG repeats in the SCA6 gene, indicating that second to S...

journal_title：Neurology

authors： Matsumura R,Futamura N,Fujimoto Y,Yanagimoto S,Horikawa H,Suzumura A,Takayanagi T

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Brain atrophy is common in subcortical ischemic vascular disease, but the underlying mechanisms are poorly understood. We set out to examine the effects of incident subcortical infarcts on cortical morphology. METHODS:A total of 276 subjects with cerebral autosomal dominant arteriopathy with subcortical infa...

journal_title：Neurology

authors： Duering M,Righart R,Csanadi E,Jouvent E,Hervé D,Chabriat H,Dichgans M

更新日期：2012-11-13 00:00:00

abstract：:Kuru plaques are the pathologic hallmark in Gerstmann-Sträussler syndrome (GSS). To demonstrate that prion protein (PrP) is a component of kuru plaque cores, we fractionated and sequenced kuru plaque core derived peptides, following digestion with Achromobacter lyticus protease I. We identified 3 PrP-derived peptides ...

journal_title：Neurology

authors： Kitamoto T,Yamaguchi K,Doh-ura K,Tateishi J

更新日期：1991-02-01 00:00:00