Abstract:
:This review summarizes evidence, primarily from recent human studies, indirectly supporting a novel hypothesis: that the assessment of healthy individuals' responses to standardized noxious stimuli in a controlled laboratory environment has important implications for the later risk of developing a broad spectrum of chronically painful conditions. Descriptions of many chronic pain syndromes note that the disorder (e.g., fibromyalgia, headache, complex regional pain syndrome) is associated with hypersensitivity to pain and with reduced endogenous inhibition of pain, implying that an individual's processing of pain-related information changes with the onset of the syndrome. However, pain sensitivity and pain-inhibitory capacity are normally distributed along a wide continuum in the general population, and recent evidence suggests that heightened baseline pain sensitivity and reduced basal pain-inhibitory processing place individuals at greater risk for experiencing severe, acute, clinical pain (e.g., postoperative pain). More controversial is the hypothesis that such individual-difference characteristics confer risk for, or protection against, chronic pain; although only a single prospective study has been published, substantial indirect evidence supports the contention that greater basal pain sensitivity and reduced pain-inhibitory capacity may act as a diathesis for chronic pain. Long-term cohort studies are necessary to test this hypothesis; such research could yield insight into the nature of chronic pain and permit greater precision in selecting high-risk individuals for chronic pain prevention research.
journal_name
Neurologyjournal_title
Neurologyauthors
Edwards RRdoi
10.1212/01.wnl.0000171862.17301.84subject
Has Abstractpub_date
2005-08-09 00:00:00pages
437-43issue
3eissn
0028-3878issn
1526-632Xpii
65/3/437journal_volume
65pub_type
杂志文章,评审相关文献
NEUROLOGY文献大全abstract::Patients with symptomatic > or = 60% (n = 134), asymptomatic > or = 80% (n = 143), and asymptomatic progressive > or = 60% (n = 25) internal carotid artery stenosis underwent stenting and were followed clinically and by Doppler-assisted duplex imaging for 27.1 +/- 15.6 months. Stroke and death from stroke occurred wit...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000167604.56223.70
更新日期:2005-07-12 00:00:00
abstract::A veterinarian contracted rabies in the course of laboratory work with homogenates of rabid goat brain. Epidemiologic study determined a respiratory mode of transmission. After a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli. Identification, isol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.1.67
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000260610.79853.47
更新日期:2007-05-01 00:00:00
abstract::There has been disagreement about the precise characteristics of "subcortical aphasia." We evaluated 14 patients with aphasia after subcortical lesions and controlled for duration, general anatomic site of lesions (capsulostriatal only), and etiology. The clinical profiles of the patients were quite similar, varying i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.10.1824
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1218
更新日期:2002-10-22 00:00:00
abstract::Trigeminal neuralgia is an uncommon but troublesome symptom of multiple sclerosis that can be refractory to conventional treatments. Misoprostol, a long-acting prostaglandin E1 analogue, relieved pain in six of seven patients who had failed to respond to conventional pharmacologic therapy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.6.1097
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To evaluate attention deficit in Alzheimer's disease (AD) and its relationship to attention deficits associated with aging and with medications altering alertness. METHODS:Ten patients with probable AD, 10 healthy old controls, and 15 young controls performed a covert orienting of spatial attention task. You...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.4.657
更新日期:1994-04-01 00:00:00
abstract::We report the vasocapacitance of the cerebral circulation, as determined by cerebral blood flow reactivity to induced hypercapnia using fluoromethane positron emission tomography, in 32 patients with unilateral anterior circulation transient ischemic attacks. A hemodynamic subset of eight patients, defined based on ex...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.1.25
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that patients with Alzheimer disease (AD) who have vascular risk factors have a worse prognosis over 18 months vs those without such risk factors. METHODS:A sample of 224 people with AD and their caregivers were recruited purposively to be representative of people with dementia in term...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000240129.46080.53
更新日期:2006-10-24 00:00:00
abstract::We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.1927
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To determine the associations between amyloid-PET, tau-PET, and atrophy with the behavioral/dysexecutive presentation of Alzheimer disease (AD), how these differ from amnestic AD, and how they correlate to clinical symptoms. METHODS:We assessed 15 patients with behavioral/dysexecutive AD recruited from a ter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011081
更新日期:2021-01-05 00:00:00
abstract::We report two patients with unique homonymous hemianopias from occipital lobe infarctions. One patient had vertical meridian sparing, and the other displayed horizontal meridian sparing. MRI correlation with the visual field defects confirmed that the vertical hemianopic meridian was represented along the border of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1170
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To study the clinical and radiologic spectrum and genotype-phenotype correlation of 4H (hypomyelination, hypodontia, hypogonadotropic hypogonadism) leukodystrophy caused by mutations in POLR3A or POLR3B. METHODS:We performed a multinational cross-sectional observational study of the clinical, radiologic, and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001002
更新日期:2014-11-18 00:00:00
abstract:OBJECTIVE:Cell-based therapies are being investigated as an adjunct to IV thrombolysis or mechanical thrombectomy in ischemic stroke. This review summarizes the potential applications as well as challenges of intravascular cell delivery in ischemic stroke. METHOD:We conducted a search of Medline as well as the clinica...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e31826959d2
更新日期:2012-09-25 00:00:00
abstract::To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.3.718
更新日期:1996-09-01 00:00:00
abstract::The authors pooled four population-based European studies to determine the risk for institutionalization and death after stroke. Risk for institutionalization was assessed in 13,095 subjects. Survival was calculated for prevalent stroke in 7929 individuals and incident stroke in 8550 individuals. The adjusted risk of ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy caused by mutations of the Notch3 gene. The disease is characterized by T2-hyperintense lesions (subcortical white matter lesions), T1-hypointense lesions (lacunar lesions), and T2...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000265221.05610.70
更新日期:2007-07-10 00:00:00
abstract::We investigated the modulatory effects of human interferon beta (IFN-beta) and gamma (IFN-gamma) on expression of class I and II major histocompatibility complex (MHC) antigens and intercellular adhesion molecule-1 (ICAM-1) in fetal human astrocytes in culture using flow cytometry and immunocytochemistry. Under the ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.2.367
更新日期:1995-02-01 00:00:00
abstract::The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000010830
更新日期:2020-11-03 00:00:00
abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.5.1238
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures. METHODS:A systematic review and meta-analysis using data on individual patients from randomized trials comparing lamotrigine with carbamazepine monotherapy. T...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/01.wnl.0000210517.03902.6e
更新日期:2006-05-09 00:00:00
abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The concept of earlier diagnosis of amyotrophic lateral sclerosis (ALS) requires in-depth investigation of its benefits and consequences. First, how good must a treatment be before ALS is determined to be a treatable condition? Analogy with cancer therapy suggests that a good quality of life after treatment is an esse...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To describe the epidemiology, etiology, clinical characteristics, treatment, outcome, and prevention of zoonotic bacterial meningitis in human adults. METHODS:We identified 16 zoonotic bacteria causing meningitis in adults. RESULTS:Zoonotic bacterial meningitis is uncommon compared to bacterial meningitis c...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000003101
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse. METHODS:A prospective cohort study was conducted among 39,754 US health pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000154528.21485.3A
更新日期:2005-03-22 00:00:00
abstract::In 2001, the authors described the clinical features of a genetically distinct autosomal dominant limb-girdle muscular dystrophy (LGMD; LGMD 1F). Using a genome-wide screen with more than 400 microsatellite markers, the authors identified a novel LGMD disease locus at chromosome 7q32.1-32.2. Within this chromosomal re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073984.46546.4f
更新日期:2003-08-12 00:00:00
abstract::In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.102
更新日期:1980-01-01 00:00:00
abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.139
更新日期:1980-02-01 00:00:00
abstract::A case-control study was conducted to assess personal and family medical history and the appearance of Alzheimer's disease. We compared 98 men with clinically diagnosed Alzheimer's disease and 162 controls, matched by sex, year of birth, and town of residence. Family history of dementia and personal history of depress...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1630
更新日期:1987-10-01 00:00:00
abstract::Four toluene abusers had evidence of severe multifocal central nervous system damage. Impairment of cognitive, cerebellar, brainstem, auditory, and pyramidal tract function, as well as CT evidence of cerebral cortical, cerebellar, and brainstem atrophy, have been noted. In addition, we found opsoclonus, ocular flutter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.10.1337
更新日期:1983-10-01 00:00:00