Abstract:
:A patient developed an amnesic syndrome after cardiopulmonary arrest. Neuropathologic examination revealed pronounced anoxic injury to both hippocampi with little damage to other hemisphere structures. The clinical and pathologic findings suggest that lesions limited to the hippocampus can cause profound amnesia.
journal_name
Neurologyjournal_title
Neurologyauthors
Cummings JL,Tomiyasu U,Read S,Benson DFdoi
10.1212/wnl.34.5.679subject
Has Abstractpub_date
1984-05-01 00:00:00pages
679-81issue
5eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Quantitative studies of the afferent pathways from hollow viscera have been limited by the lack of an easily controlled, reproducible visceral stimulus. We adapted a slow distention device to allow for rapid distention to study the afferent pathways from the rectum. The device produced a pressure increase of 10 mm Hg ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.8.1510
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004060
更新日期:2017-07-04 00:00:00
abstract::Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period. Control spinal fluids for age-matched comparison were obtained from 194 neurologic and nonneurologic pediatric patients. A rapid decline i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.907
更新日期:1985-06-01 00:00:00
abstract::We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000249309.80510.63
更新日期:2006-12-26 00:00:00
abstract::Spasticity may result in part from segmental spinal disinhibition. We determined the content and specific activity of glycine (the putative neurotransmitter thought to mediate spinal postsynaptic inhibition) and serine (the probable precursor of glycine) in feline spastic spinal cord following the intra-aortic adminis...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.262
更新日期:1979-02-01 00:00:00
abstract::We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder (RBD) after extensive polysomnographic and neurologic evaluations. Thirty-eight percent (11/29) were eventually diagnosed as having a parkinsonian disorder (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.388
更新日期:1996-02-01 00:00:00
abstract::To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.9.1240
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:Since Alzheimer disease (AD) is a slowly progressive disorder and its pathologic features are likely to be present for many years before symptoms become manifest, we investigated whether microstructural white matter changes similar to those identified in patients with AD can be detected in cognitively normal ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182661f4d
更新日期:2012-08-21 00:00:00
abstract:OBJECTIVE:To identify regional metabolic brain networks related specifically to the presence of tremor in PD. BACKGROUND:The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.803
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare it with that of individuals in the United Kingdom. METHODS:Brain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and Decembe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010171
更新日期:2020-09-01 00:00:00
abstract::Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan's syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.814
更新日期:2002-03-12 00:00:00
abstract::A kindred is described with a dominantly inherited "pure" cerebellar ataxia in which the currently known spinocerebellar ataxias have been excluded. In the eight subjects studied, a notable clinical feature is slow progression, with the three least affected having only a mild degree of gait ataxia after three or more ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.10.1913
更新日期:2001-11-27 00:00:00
abstract::In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in mu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1209
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Patients with Parkinson disease (PD) may present with various types of pain. In some instances, no cause can be identified and pain is considered a primary disorder (primary central pain [PCP]). We hypothesized that PCP in patients with PD (PD-PCP) may be due to a dysfunction of pain pathways or the processi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000295669.12443.d3
更新日期:2007-12-04 00:00:00
abstract::Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review, several biological activities of IFN-beta are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation. Furthermor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.3.682
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the retinal nerve fiber layer (RNFL) thickness and macular volume in neuromyelitis optica (NMO) spectrum patients using optical coherence tomography (OCT). BACKGROUND:OCT can quantify damage to retinal ganglion cell axons and can identify abnormalities in multiple sclerosis and optic neuritis (ON...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181af78b8
更新日期:2009-07-28 00:00:00
abstract::A moderately retarded Japanese boy, with a normal male karyotype (46,XY), was diagnosed to have a subcortical band heterotopia or double cortex syndrome. The band heterotopia was relatively thick compared with that of other patients reported. On T2-weighted coronal MR sections, there were numerous radial linear struct...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.6.1701
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000002941
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Genetic studies of PD frequently rely on family history interviews (FHI), yet the accuracy of data obtained in this way is unclear. OBJECTIVE:To assess the interinformant reliability and validity of family history information on PD in first-degree relatives of PD cases and controls. METHODS:A structured FH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000074784.35961.c0
更新日期:2003-07-08 00:00:00
abstract::We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1260
更新日期:1996-11-01 00:00:00
abstract::We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.276
更新日期:1986-02-01 00:00:00
abstract::We attempted to define the role of subtle changes in the normal-appearing white matter (NAWM) in the development of disability in multiple sclerosis (MS). Twenty-seven clinically definite MS patients with either relapsing-remitting or chronic-progressive courses and 10 sex- and age-matched controls entered the study. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.3.478
更新日期:1995-03-01 00:00:00
abstract::In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.467
更新日期:1987-03-01 00:00:00
abstract::A 12-year-old girl who had zoster ophthalmicus 10 months earlier presented with hemiparesis and corresponding basal ganglionic infarction related to middle cerebral artery branch thrombosis ipsilateral to the zoster. Hematologic evaluation disclosed protein C deficiency. This represents the first zoster-associated str...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.5.1128
更新日期:1999-09-22 00:00:00
abstract:OBJECTIVE:To identify the metabolic signature of the various levels of cognitive deficits in amyotrophic lateral sclerosis (ALS) using 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). METHODS:A total of 170 ALS cases consecutively enrolled at the ALS Center of Turin underwent brain 18F-FDG-PET and were classified as ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002242
更新日期:2016-01-05 00:00:00
abstract:BACKGROUND:Silent infarcts are commonly discovered on cranial MRI in the elderly. OBJECTIVE:To examine the association between risk of stroke and presence of silent infarcts, alone and in combination with other stroke risk factors. METHODS:Participants (3,324) in the Cardiovascular Health Study (CHS) without a histor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.7.1222
更新日期:2001-10-09 00:00:00
abstract:OBJECTIVE:To evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls. METHODS:A total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004110
更新日期:2017-07-18 00:00:00
abstract:OBJECTIVE:The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship betwee...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000003534
更新日期:2017-01-24 00:00:00
abstract::A case-control study was conducted to assess personal and family medical history and the appearance of Alzheimer's disease. We compared 98 men with clinically diagnosed Alzheimer's disease and 162 controls, matched by sex, year of birth, and town of residence. Family history of dementia and personal history of depress...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1630
更新日期:1987-10-01 00:00:00
abstract::Resources of the Rochester Epidemiology Project were used to estimate prevalence rates for dementia on January 1, 1975, 1980, and 1985, and to evaluate trends over time. Prevalence rates increased with age for both men and women. There was no difference in the prevalence rates for January 1, 1975, and January 1, 1980,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.1.75
更新日期:1995-01-01 00:00:00