Abstract:
:To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30 minutes markedly decreased 51Cr specific release, which could not be restored by addition of either 10% guinea pig serum or normal human serum. Thus, both GBS and control serum contain heat-labile serum factors that can induce cytotoxic reactions by Schwann cells.
journal_name
Neurologyjournal_title
Neurologyauthors
Lisak RP,Kuchmy D,Armati-Gulson PJ,Brown MJ,Sumner AJdoi
10.1212/wnl.34.9.1240subject
Has Abstractpub_date
1984-09-01 00:00:00pages
1240-3issue
9eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
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