Abstract:
:In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in muscle, lymphocytes, cultured fibroblasts, and urine of asymptomatic relatives. Current biochemical techniques do not discriminate between persons heterozygous for the generalized form and those heterozygous for the muscular form. To explain the coexistence of both forms in the same family, the infant with the generalized form or her grandfather with the muscular form must have been a genetic compound of different mutant alleles for acid alpha-glucosidase.
journal_name
Neurologyjournal_title
Neurologyauthors
Loonen MC,Busch HF,Koster JF,Martin JJ,Niermeijer MF,Schram AW,Brouwer-Kelder B,Mekes W,Slee RG,Tager JMdoi
10.1212/wnl.31.10.1209subject
Has Abstractpub_date
1981-10-01 00:00:00pages
1209-16issue
10eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
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