Abstract:
:We investigated the possible role of potassium deficiency, a recognized cause of myopathy, in the pathogenesis of experimental acute alcoholic myopathy (EAM) in the rat. Alcohol-treated animals receiving the same dietary potassium as controls developed mild hypokalemia; however, muscle potassium was preserved or elevated even in the presence of scattered muscle fiber necrosis. Increasing dietary potassium raised serum potassium but did not prevent EAM. These data indicate that hypokalemia in EAM is due to potassium redistribution between intra- and extracellular compartments rather than potassium deficiency, and confirm clinical observations that alcohol-induced muscle injury occurs independently of potassium deficiency.
journal_name
Neurologyjournal_title
Neurologyauthors
Haller RG,Carter NW,Ferguson E,Knochel JPdoi
10.1212/wnl.34.4.529subject
Has Abstractpub_date
1984-04-01 00:00:00pages
529-32issue
4eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
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