The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study.

abstract：OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...

journal_title：Neurology

authors： Lochmüller H,Behin A,Caraco Y,Lau H,Mirabella M,Tournev I,Tarnopolsky M,Pogoryelova O,Woods C,Lai A,Shah J,Koutsoukos T,Skrinar A,Mansbach H,Kakkis E,Mozaffar T

更新日期：2019-04-30 00:00:00

abstract：:MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...

journal_title：Neurology

authors： Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Patients with Parkinson disease (PD) may present with various types of pain. In some instances, no cause can be identified and pain is considered a primary disorder (primary central pain [PCP]). We hypothesized that PCP in patients with PD (PD-PCP) may be due to a dysfunction of pain pathways or the processi...

journal_title：Neurology

authors： Schestatsky P,Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Tolosa E,Chaves ML

更新日期：2007-12-04 00:00:00

abstract：OBJECTIVE:To determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1). METHODS:Children 0.5-18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion. This consisted of children with NF1 with or withou...

journal_title：Neurology

authors： Avery RA,Mansoor A,Idrees R,Biggs E,Alsharid MA,Packer RJ,Linguraru MG

更新日期：2016-06-14 00:00:00

abstract：:Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model. Sporadic PD is likely to be caused by the comb...

journal_title：Neurology

authors： Johnson WG

更新日期：1991-05-01 00:00:00

abstract：:The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of ...

journal_title：Neurology

authors： Stevens M,van Duijn CM,de Knijff P,van Broeckhoven C,Heutink P,Oostra BA,Niermeijer MF,van Swieten JC

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To assess the clinical, urodynamic, and neurophysiologic features of patients with persisting bladder, bowel, and sexual dysfunction after transverse myelitis in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease. METHODS:Patients with a history of MOG-Ab disease-related transverse myelitis seen p...

journal_title：Neurology

authors： Li V,Malladi P,Simeoni S,Pakzad M,Everett R,Satukijchai C,Leite MI,Palace J,Panicker JN

更新日期：2020-11-24 00:00:00

abstract：OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...

journal_title：Neurology

authors： Wilson RS,Capuano AW,Boyle PA,Hoganson GM,Hizel LP,Shah RC,Nag S,Schneider JA,Arnold SE,Bennett DA

更新日期：2014-08-19 00:00:00

abstract：:CNS dysfunction occurs frequently in patients with HIV infection. To better define the role of HIV in the pathogenesis of neurologic dysfunction, HIV isolation and antibody studies were investigated from the CSF in 52 seropositive patients, 29 with and 23 without neurologic signs and symptoms, in various stages of dis...

journal_title：Neurology

authors： Resnick L,Berger JR,Shapshak P,Tourtellotte WW

更新日期：1988-01-01 00:00:00

abstract：:Assay of anti-striated muscle antibodies (StrAb) is used as a diagnostic test for thymoma in individuals with myasthenia gravis. Unfortunately, false positive results are common, and their effect on test accuracy is magnified by the relatively low frequency of thymoma in myasthenics. We estimated the predictive values...

journal_title：Neurology

authors： Lanska DJ

更新日期：1991-04-01 00:00:00

abstract：:Both mevalonic aciduria, characterized by psychomotor retardation, cerebellar ataxia, recurrent fever attacks, and death in early childhood, and hyper-immunoglobulin D (hyper-IgD) syndrome, with recurrent fever attacks without neurologic symptoms, are caused by a functional deficiency of mevalonate kinase. In a system...

journal_title：Neurology

authors： Simon A,Kremer HP,Wevers RA,Scheffer H,De Jong JG,Van Der Meer JW,Drenth JP

更新日期：2004-03-23 00:00:00

abstract：BACKGROUND:In acute cerebral ischemia, two variables characterize the extent of hypoperfusion: the volume of hypoperfused tissue and the intensity of hypoperfusion within these regions. We evaluated the determinants of the intensity of hypoperfusion within oligemic regions among patients who were eligible for recanaliz...

journal_title：Neurology

authors： Bang OY,Saver JL,Alger JR,Starkman S,Ovbiagele B,Liebeskind DS,UCLA Collateral Investigators.

更新日期：2008-11-25 00:00:00

abstract：OBJECTIVE:To assess hearing in patients with essential tremor (ET) vs patients with Parkinson disease (PD) and normal controls. METHODS:The authors assessed demographic and clinical information including use of hearing aids in 250 patients with ET, 127 patients with PD, and 127 normal controls. The authors administere...

journal_title：Neurology

authors： Ondo WG,Sutton L,Dat Vuong K,Lai D,Jankovic J

更新日期：2003-10-28 00:00:00

abstract：:Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...

journal_title：Neurology

authors： Eerola J,Hernandez D,Launes J,Hellström O,Hague S,Gulick C,Johnson J,Peuralinna T,Hardy J,Tienari PJ,Singleton AB

更新日期：2003-10-14 00:00:00

abstract：:Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 pat...

journal_title：Neurology

authors： Leonard JR,Perry A,Rubin JB,King AA,Chicoine MR,Gutmann DH

更新日期：2006-10-24 00:00:00

abstract：:Thirty-one (23%) of 137 patients treated for leptomeningeal metastases (LM) achieved a sustained off-therapy response of at least 6 months' duration following treatment by a standard protocol. Of the 31 patients, equal distribution was found among various tumors: lymphoma, 13/44 (29%); breast carcinoma, 10/51 (20%); a...

journal_title：Neurology

authors： Siegal T,Lossos A,Pfeffer MR

更新日期：1994-08-01 00:00:00

abstract：:The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod...

journal_title：Neurology

authors： Hatano Y,Sato K,Elibol B,Yoshino H,Yamamura Y,Bonifati V,Shinotoh H,Asahina M,Kobayashi S,Ng AR,Rosales RL,Hassin-Baer S,Shinar Y,Lu CS,Chang HC,Wu-Chou YH,Ataç FB,Kobayashi T,Toda T,Mizuno Y,Hattori N

更新日期：2004-10-26 00:00:00

abstract：:We analyzed our experience with cough, exertional, and vascular sexual headaches, evaluated the interrelationships among them, and examined the possible symptomatic cases. Seventy-two patients consulted us because of headaches precipitated by coughing (n = 30), physical exercise (n = 28), or sexual excitement (n = 14)...

journal_title：Neurology

authors： Pascual J,Iglesias F,Oterino A,Vázquez-Barquero A,Berciano J

更新日期：1996-06-01 00:00:00

abstract：:We tested three serotonin antagonists--lysergic acid diethylamide (LSD), 2-bromolysergic acid diethylamide (BOL), and cinanserin--for effects on experimental spinal cord ischemia in the rabbit. Blood flow to spinal cord was obstructed. Drugs were administered before or after initiation of occlusion, and flow was later...

journal_title：Neurology

authors： Zivin JA,Venditto JA

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To determine whether physical activity and body mass index (BMI) predict instrumental or basic activities of daily living (I/ADL) trajectories before or after stroke compared to individuals who remained stroke-free. METHODS:Using a prospective cohort, the Health and Retirement Study, we followed adults witho...

journal_title：Neurology

authors： Rist PM,Capistrant BD,Mayeda ER,Liu SY,Glymour MM

更新日期：2017-05-02 00:00:00

abstract：:Recurrent episodes of oscillopsia, rotational vertigo, and postural imbalance were elicited and modulated by changing the horizontal head positions of a patient with an arachnoid cyst in the right cerebellopontine angle that distorted the vestibulocochlear nerve. Oculomotor analysis revealed two different types of att...

journal_title：Neurology

authors： Arbusow V,Strupp M,Dieterich M,Jäger L,Hischa A,Schulz P,Brandt T

更新日期：1998-11-01 00:00:00

abstract：:We performed a prospective study of neuroimaging studies and temporal lobe pathology in 13 patients with facial asymmetry and intractable partial epilepsy of temporal lobe origin. The 13 patients, derived from 50 consecutive patients with nonlesional medically refractory partial epilepsy, were deemed appropriate candi...

journal_title：Neurology

authors： Cascino GD,Luckstein RR,Sharbrough FW,Jack CR Jr

更新日期：1993-04-01 00:00:00

abstract：:We retrospectively examined the clinical courses of 20 children with severe near-drowning and divided their outcomes into 3 groups: normal (4), persistent vegetative state (9), and dead (7). We reviewed serial blood glucose levels and cerebral blood flow measured by stable xenon computed tomography within the 1st 48 h...

journal_title：Neurology

authors： Ashwal S,Schneider S,Tomasi L,Thompson J

更新日期：1990-05-01 00:00:00

abstract：:Restless legs syndrome (RLS) is a common neurologic disorder whose prevalence has been estimated at 4 to 10% of the general population. Although its pathophysiology remains unknown, dopaminergic mechanisms are believed to play a central role. Furthermore, dopaminergic drugs have shown therapeutic efficacy in various l...

journal_title：Neurology

authors： Garcia-Borreguero D,Odin P,Serrano C

更新日期：2003-09-23 00:00:00

abstract：:A rare case of solitary CNS chloroma in a patient with chronic granulocytic leukemia (CGL) is described. This appears to be the first reported case of intracranial chloroma in CGL without systemic blastic crisis. ...

journal_title：Neurology

authors： Lysy J,Globus M,Okon E,Polliack A,Chowers I

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors. METHODS:Patients with definite MS, onset prior to July 1988, registered with a BCMS clinic before July 1998, with at least one E...

journal_title：Neurology

authors： Tremlett H,Devonshire V

更新日期：2006-09-26 00:00:00

abstract：:We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the ep...

journal_title：Neurology

authors： Baumgartner C,Lindinger G,Ebner A,Aull S,Serles W,Olbrich A,Lurger S,Czech T,Burgess R,Lüders H

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between neurology inpatient satisfaction and (1) number of physicians involved in the patient's care and (2) patients' ability to identify their physicians. METHODS:A 10-item questionnaire addressing patient satisfaction and identification of physicians on the care team was admi...

journal_title：Neurology

authors： Leon Guerrero CR,Anderson T,Zazulia AR

更新日期：2018-02-13 00:00:00

abstract：OBJECTIVE:To determine whether the CT angiography (CTA) spot sign marks bleeding complications during and after surgery for spontaneous intracerebral hemorrhage (ICH). METHODS:In a 2-center study of consecutive spontaneous ICH patients who underwent CTA followed by surgical hematoma evacuation, 2 experienced readers (...

journal_title：Neurology

authors： Brouwers HB,Raffeld MR,van Nieuwenhuizen KM,Falcone GJ,Ayres AM,McNamara KA,Schwab K,Romero JM,Velthuis BK,Viswanathan A,Greenberg SM,Ogilvy CS,van der Zwan A,Rinkel GJ,Goldstein JN,Klijn CJ,Rosand J

更新日期：2014-09-02 00:00:00

abstract：OBJECTIVE:This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS. PATIENTS:There were 3...

journal_title：Neurology

authors： Rovaris M,Filippi M,Falautano M,Minicucci L,Rocca MA,Martinelli V,Comi G

更新日期：1998-06-01 00:00:00