PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.

abstract：OBJECTIVE:To assess the feasibility of using MRI measurements as a surrogate endpoint for disease progression in a therapeutic trial for AD. METHODS:A total of 362 patients with probable AD from 38 different centers participated in the MRI portion of a 52-week randomized placebo-controlled trial of milameline, a musca...

journal_title：Neurology

authors： Jack CR Jr,Slomkowski M,Gracon S,Hoover TM,Felmlee JP,Stewart K,Xu Y,Shiung M,O'Brien PC,Cha R,Knopman D,Petersen RC

更新日期：2003-01-28 00:00:00

abstract：BACKGROUND:Frontotemporal dementia (FTD) is currently distinguished from AD primarily on the basis of behavioral features because studies of cognition have shown negligible or inconsistent differences. However, the poor discriminability of cognitive measures may relate to reliance on imprecise clinically diagnosed grou...

journal_title：Neurology

authors： Rascovsky K,Salmon DP,Ho GJ,Galasko D,Peavy GM,Hansen LA,Thal LJ

更新日期：2002-06-25 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of headaches in a Chinese elderly population. BACKGROUND:There are few headache surveys in the elderly. Previous studies have shown a low headache prevalence in Chinese. METHODS: TARGET POPULATION:eligible registered residents > or = 65 years old (N = 2,003) in two townships o...

journal_title：Neurology

authors： Wang SJ,Liu HC,Fuh JL,Liu CY,Lin KP,Chen HM,Lin CH,Wang PN,Hsu LC,Wang HC,Lin KN

更新日期：1997-07-01 00:00:00

abstract：:We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...

journal_title：Neurology

authors： Azulay JP,Blin O,Pouget J,Boucraut J,Billé-Turc F,Carles G,Serratrice G

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial. OBJECTIVE:To investigate a possible relationship between the genetic variants of APOE and brain atrophy in patients with AD. METHODS:Using ...

journal_title：Neurology

authors： Hashimoto M,Yasuda M,Tanimukai S,Matsui M,Hirono N,Kazui H,Mori E

更新日期：2001-10-23 00:00:00

abstract：OBJECTIVE:Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD:High school and college students were recruited via social ...

journal_title：Neurology

authors： Saif N,Niotis K,Dominguez M,Hodes JF,Woodbury M,Amini Y,Sadek G,Scheyer O,Caesar E,Hristov H,Knowlton N,Lee P,McInnis M,Isaacson RS

更新日期：2020-10-20 00:00:00

abstract：:Revascularization time windows for patients with acute ischemic stroke are generally restricted to 8 hours. Later treatment attempts require more accurate prediction of risk and benefit, as safety and efficacy at these time strata are less well demonstrated. Advanced imaging techniques identify irreversible infarction...

journal_title：Neurology

authors： Janjua N

更新日期：2012-09-25 00:00:00

abstract：:A 66-year-old woman with acute idiopathic polyneuritis (Landry-Guillain-Barré [LGB] syndrome) had normal extraocular movements, but her pupils did not react to light or accommodation. This is the first such case to be reported. Pharmacologic testing pointed to postganglionic involvement of parasympathetic and sympathe...

journal_title：Neurology

authors： Williams D,Brust JC,Abrams G,Challenor Y,Devereaux M

更新日期：1979-07-01 00:00:00

abstract：:We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...

journal_title：Neurology

authors： Lolas F,Hoeppner TJ,Morrell F

更新日期：1979-02-01 00:00:00

abstract：:We used riboflavin to treat a patient with lipid myopathy, reduced exercise capacity, intolerance to fasting, and reduced concentrations of carnitine in muscle and serum. Although carnitine concentrations did not change, exercise capacity doubled, and response to fasting improved. Muscle enzyme assay showed that palmi...

journal_title：Neurology

authors： Carroll JE,Shumate JB,Brooke MH,Hagberg JM

更新日期：1981-12-01 00:00:00

abstract：:Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...

journal_title：Neurology

authors： Fromm GH,Glass JD,Chattha AS,Martinez AJ,Silverman M

更新日期：1980-02-01 00:00:00

abstract：:An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...

journal_title：Neurology

authors： Lavi E,Montone KT,Rorke LB,Kliman HJ

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy. METHODS:We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromuscular transm...

journal_title：Neurology

authors： Régal L,Shen XM,Selcen D,Verhille C,Meulemans S,Creemers JW,Engel AG

更新日期：2014-04-08 00:00:00

abstract：:Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated...

journal_title：Neurology

authors： Hatanpaa KJ,Blass DM,Pletnikova O,Crain BJ,Bigio EH,Hedreen JC,White CL 3rd,Troncoso JC

更新日期：2004-08-10 00:00:00

abstract：:Thirty-one individuals awaiting trial or sentencing for murder or undergoing an appeal process requested a neurologic examination through legal counsel. We attempted in each instance to obtain EEG, MRI or CT, and neuropsychological testing. Neurologic examination revealed evidence of "frontal" dysfunction in 20 (64.5%...

journal_title：Neurology

authors： Blake PY,Pincus JH,Buckner C

更新日期：1995-09-01 00:00:00

abstract：:A striking behavioral abnormality is described in three individuals who had severe head trauma. At a point when general mnestic capabilities had returned to a near normal level, the patients persistently relocated the hospital at another geographical site, even in the face of compelling counter-evidence. The strong pa...

journal_title：Neurology

authors： Benson DF,Gardner H,Meadows JC

更新日期：1976-02-01 00:00:00

abstract：OBJECTIVE:To apply multisequence MRI techniques to patients with clinically isolated syndromes, to document the pattern and frequency of abnormalities at baseline and early follow-up, and to determine their predictive values for the early development of clinical MS. BACKGROUND:Disseminated lesions on T2-weighted brain...

journal_title：Neurology

authors： Brex PA,O'Riordan JI,Miszkiel KA,Moseley IF,Thompson AJ,Plant GT,Miller DH

更新日期：1999-10-12 00:00:00

abstract：OBJECTIVE:To test the hypothesis that US neurologists were experiencing significant challenges with lack of personal protective equipment (PPE), rapid changes in practice, and varying institutional protocols, we conducted this survey study. The current coronavirus disease of 2019 (COVID-19) pandemic has caused widespre...

journal_title：Neurology

authors： Sharma A,Maxwell CR,Farmer J,Greene-Chandos D,LaFaver K,Benameur K

更新日期：2020-08-04 00:00:00

abstract：:Restless legs syndrome (RLS) is a common neurologic disorder that affects 5 to 10% of the population and increases in prevalence with aging. The clinical hallmarks of RLS include dysesthesias or paresthesias in the legs and sometimes the arms, occurring primarily at rest, which are usually worse in the evening and are...

journal_title：Neurology

authors： Comella CL

更新日期：2002-02-26 00:00:00

abstract：:A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...

journal_title：Neurology

authors： Strom T,Schneck SA

更新日期：1991-02-01 00:00:00

abstract：:In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but ...

journal_title：Neurology

authors： Niemeier M,Karnath HO

更新日期：2000-01-25 00:00:00

abstract：:Two women with myasthenia gravis became apneic immediately after IV injection of iodinated contrast material for CT. Aggravation of myasthenia continued for days after this initial reaction. ...

journal_title：Neurology

authors： Chagnac Y,Hadani M,Goldhammer Y

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of eptinezumab, a humanized anti-calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM). METHODS:The Prevention of Migraine via Intravenous ALD403 Safety and Efficacy-2 (PROMISE-2) study was a phase 3, multicenter, randomi...

journal_title：Neurology

authors： Lipton RB,Goadsby PJ,Smith J,Schaeffler BA,Biondi DM,Hirman J,Pederson S,Allan B,Cady R

更新日期：2020-03-31 00:00:00

abstract：OBJECTIVE:To determine whether cognitive impairment in Parkinson disease (PD) and Alzheimer disease (AD) derives from the same network pathology. METHODS:We analyzed 18F-fluorodeoxyglucose PET scans from 40 patients with AD and 40 age-matched healthy controls from the Alzheimer's Disease Neuroimaging Initiative and sc...

journal_title：Neurology

authors： Mattis PJ,Niethammer M,Sako W,Tang CC,Nazem A,Gordon ML,Brandt V,Dhawan V,Eidelberg D

更新日期：2016-11-01 00:00:00

abstract：:Automatisms are commonly seen in epilepsy, either ictally or postictally. However, most automatisms are simple, with hand movements, mouth smacking, nose-rubbing, repetition of a single word, or coughing, grunting, or screeching. Complex automatisms are less common and striking. The authors report two cases of seizure...

journal_title：Neurology

authors： Doherty MJ,Wilensky AJ,Holmes MD,Lewis DH,Rae J,Cohn GH

更新日期：2002-11-12 00:00:00

abstract：BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...

journal_title：Neurology

authors： Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt J

更新日期：2002-04-09 00:00:00

abstract：BACKGROUND:Most cavernous sinus dural arteriovenous malformations (CSdAVM) have a benign clinical course. Those CSdAVM that drain into cortical veins have an increased risk for neurologic complications. OBJECTIVE:To find whether a specific clinical sign predicts cortical venous drainage (CVD) in CSdAVM. METHODS:The r...

journal_title：Neurology

authors： Stiebel-Kalish H,Setton A,Berenstein A,Kalish Y,Nimii Y,Kupersmith MJ

更新日期：2002-05-28 00:00:00

abstract：OBJECTIVE:In this study, we compared a cognition-specific computer-based cognitive training program with a motion-controlled computer sports game that is not cognition-specific for their ability to enhance cognitive performance in various cognitive domains in patients with Parkinson disease (PD). METHODS:Patients with...

journal_title：Neurology

authors： Zimmermann R,Gschwandtner U,Benz N,Hatz F,Schindler C,Taub E,Fuhr P

更新日期：2014-04-08 00:00:00

abstract：OBJECTIVES:We used functional MRI (fMRI), transcranial Doppler ultrasound, and visual evoked potentials (VEPs) to determine the nature of blood flow responses to functional brain activity and carbon dioxide (CO2) inhalation in patients with cerebral amyloid angiopathy (CAA), and their association with markers of CAA se...

journal_title：Neurology

authors： Peca S,McCreary CR,Donaldson E,Kumarpillai G,Shobha N,Sanchez K,Charlton A,Steinback CD,Beaudin AE,Flück D,Pillay N,Fick GH,Poulin MJ,Frayne R,Goodyear BG,Smith EE

更新日期：2013-11-05 00:00:00

abstract：:Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month afte...

journal_title：Neurology

authors： Bosch EP,Pierach CA,Bossenmaier I,Cardinal R,Thorson M

更新日期：1977-11-01 00:00:00