Abstract:
BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affects 10-year survival equally in men and women. METHODS:APOE testing was performed on 125 patients with probable AD enrolled in the Johns Hopkins AD Research Center between November 1984 and March 1987. The 39 men and 86 women were followed at 6-month intervals until censoring (by death or withdrawal from the study) or March 1997. Patients were dichotomized into those with and those without at least one epsilon 4 allele. For each sex, a Cox proportional hazards regression, allowing for delayed entry and covarying for age at onset, was used to examine the effect of epsilon 4 on survival. RESULTS:All patients who died during the study period and had autopsy (n = 92) were found to have definite AD. Average survival from disease onset did not differ by sex (12.1 years in men; 12.3 years in women). In neither sex were differences found between epsilon 4-positive and epsilon 4-negative subgroups in education, duration of AD at entry, or severity of dementia. However, in both sexes the epsilon 4-positive subgroup was approximately 3 years older at onset of AD and at entry to the study than the epsilon 4-negative subgroup. Adjusting for age at onset, the presence of an epsilon 4 allele significantly increased the relative risk of death only for men (RR = 2.69; 95% CI = 1.23 to 5.87). CONCLUSIONS:In this sample of mostly white, well-educated research participants with AD, the APOE epsilon 4 allele was associated with shorter survival in men but not in women.
journal_name
Neurologyjournal_title
Neurologyauthors
Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt Jdoi
10.1212/wnl.58.7.1045subject
Has Abstractpub_date
2002-04-09 00:00:00pages
1045-50issue
7eissn
0028-3878issn
1526-632Xjournal_volume
58pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies. METHODS:The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BA...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e318258f785
更新日期:2012-06-05 00:00:00
abstract:OBJECTIVE:To incorporate standardized documentation into an epilepsy clinic and to use these standardized data to compare patients' perception of epilepsy diagnosis to provider documentation. METHODS:Using quality improvement methodology, we implemented interventions to increase documentation of epilepsy diagnosis, se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009778
更新日期:2020-07-14 00:00:00
abstract::Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1487
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:To report the clinical and pelvic CT findings in six patients with obturator mononeuropathy caused by cancer. DESIGN:A clinical case series of six patients followed for 2 months to 10 years (one patient lost to follow-up). SETTING:Three referral centers. PATIENTS:Three men and three women, ages 52 to 81 ye...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.8.1489
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Sleep-disordered breathing (SDB) and respiratory failure (RF) are complications of acid maltase deficiency (AMD), a rare hereditary myopathy. OBJECTIVE:To define the relationship between lung and respiratory muscle function, to establish incidence and patterns of SDB, and to determine daytime predictors of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.7.1290
更新日期:2001-10-09 00:00:00
abstract:OBJECTIVE:Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, affecting 1 in 2,500 individuals. Mitochondrial DNA (mtDNA) mutations are not generally considered within the differential diagnosis of patients with uncomplicated inherited neuropathy, despite the essential requirement of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182698d8d
更新日期:2012-09-11 00:00:00
abstract:OBJECTIVE:To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as retinal infarctions or the congenital morning glory anomaly may have subtle subclinical retinal changes. METHODS:In this cross-sectional study, spectral domain optical coherence tomography was used to analyze...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001832
更新日期:2015-08-11 00:00:00
abstract:OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000715
更新日期:2014-08-19 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Posterior cortical atrophy (PCA) is a progressive neurodegenerative syndrome that presents with cortical visual dysfunction and relatively preserved memory. Although higher cortical visual syndromes are well known in PCA, visual field defects detected by computerized visual field (CVF) perimetr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823e9f2a
更新日期:2011-12-13 00:00:00
abstract::We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.38
更新日期:1990-01-01 00:00:00
abstract::Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of ser...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.8.1687
更新日期:1999-05-12 00:00:00
abstract:OBJECTIVE:To use a historical placebo control design to determine whether lithium carbonate slows progression of amyotrophic lateral sclerosis (ALS). METHODS:A phase II trial was conducted at 10 sites in the Western ALS Study Group using similar dosages (300-450 mg/day), target blood levels (0.3-0.8 mEq/L), outcome me...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31822dc7a5
更新日期:2011-09-06 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes. METHODS:A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measur...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000438224.25600.6c
更新日期:2014-01-07 00:00:00
abstract::We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE. Lorazepam entered the bloodstream rapidly following intraperitoneal injection. Brain concentrations peaked 10 minutes after peak serum levels w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.6.990
更新日期:1990-06-01 00:00:00
abstract::As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical sc...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000133122.14824.25
更新日期:2004-07-13 00:00:00
abstract::A 14-year-old girl developed severe bilateral optic neuritis 1 week after the onset of chickenpox. Though previous case reports state that complete recovery is the rule, this child had a persistent decrease in visual acuity in the right eye and loss of color vision and defects in visual fields in both eyes. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.3.501
更新日期:1988-03-01 00:00:00
abstract::The role of genetic factors in determining risk for status epilepticus (SE) was examined in twins identified using the population-based Virginia Twin Registry. Concordance rates for SE were 0.38 for monozygotic (MZ) and 0.00 for dizygotic (DZ) twins, with the rate in MZs being significantly increased over DZs. The pre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.558
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:The MS Functional Composite (MSFC), a recently developed outcome measure for clinical trials, was applied to 240 patients with MS to explore its utility in different subgroups of MS and for comparison with the Expanded Disability Status Scale (EDSS). METHOD:Three clinical dimensions were examined: arm/hand f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.6.1233
更新日期:2000-03-28 00:00:00
abstract::The authors have developed an MG activities of daily living (ADL) profile (MG-ADL)-a simple eight-question survey of MG symptoms. In 254 consecutive encounters with established MG patients, the authors compared scores from the MG-ADL to the quantitative MG score (QMG)-a standardized, reliable scale used in clinical tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.7.1487
更新日期:1999-04-22 00:00:00
abstract::We reviewed the historical features, preoperative diagnostic evaluation, operative procedure, and surgical outcome in 16 patients with refractory frontal lobe epilepsy. Clinical expression of the epilepsy varied widely, particularly with respect to seizure characteristics, although high monthly seizure frequency and a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.4.780
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Bilateral absent N20 responses of median nerve somatosensory evoked potentials (SEPs) reliably predict poor prognosis after cardiac arrest. However, the studies supporting this fact were carried out before hypothermia was established as standard treatment. Recent evidence suggests that hypothermia treatment ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d5a631
更新日期:2010-03-23 00:00:00
abstract:OBJECTIVE:To assess the surgical and hardware complications in a series of 81 consecutive patients undergoing subthalamic (STN) deep brain stimulation (DBS) for Parkinson disease (PD). METHODS:The authors prospectively documented surgical and hardware complications occurring at the time of surgery and at subsequent ne...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000134650.91974.1a
更新日期:2004-08-24 00:00:00
abstract::Proximal myotonic myopathy (PROMM) is an autosomal dominantly inherited multisystemic disorder characterized by myotonia, proximal muscle weakness, and cataracts. This disorder is not linked to the gene locus of myotonic dystrophy (DM). We describe three new families with PROMM. In all patients, CTG repeats of the DM ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.1.33
更新日期:1997-01-01 00:00:00
abstract::IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000068334.04500.08
更新日期:2003-06-10 00:00:00
abstract::Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.9.1387
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Resistance to insulin-mediated glucose uptake by peripheral tissues is a cardinal defect in type 2 diabetes mellitus. Insulin resistance is also common among nondiabetic individuals, and may be an important risk factor for stroke in both populations. The authors review the definition, epidemiolog...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.6.809
更新日期:2002-09-24 00:00:00
abstract::We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regres...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.2.244
更新日期:1995-02-01 00:00:00
abstract::Dementia occurs infrequently in patients with giant cell (temporal) arteritis (GCA). Three elderly women with biopsy-proven GCA showed abrupt cognitive decline during periods of clinically active GCA, 1 to 6 months after diagnostic temporal artery biopsy, during periods of corticosteroid taper. One patient had additio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.5.753
更新日期:1990-05-01 00:00:00
abstract::A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1682
更新日期:1991-10-01 00:00:00
abstract::Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cyt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.9.1023
更新日期:1982-09-01 00:00:00