Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases.

abstract：OBJECTIVES:Assuming the involvement of homocysteine in a generalized small-vessel disease, we investigated the association of homocysteine levels with progression of white matter lesions, lacunar infarcts, and kidney disease. METHODS:Within the SMART-MR (Second Manifestations of ARTerial disease-Magnetic Resonance) St...

journal_title：Neurology

authors： Kloppenborg RP,Geerlings MI,Visseren FL,Mali WP,Vermeulen M,van der Graaf Y,Nederkoorn PJ,SMART Study Group.

更新日期：2014-03-04 00:00:00

abstract：OBJECTIVE:To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men. BACKGROUND:X-linked PNH caused by FLN1 mutations (MIM #300049) implies prenatal or early postnatal lethality in boys and 50% recurrence risk in daughters of affected women. MET...

journal_title：Neurology

authors： Guerrini R,Mei D,Sisodiya S,Sicca F,Harding B,Takahashi Y,Dorn T,Yoshida A,Campistol J,Krämer G,Moro F,Dobyns WB,Parrini E

更新日期：2004-07-13 00:00:00

abstract：:The ability of two noninvasive diagnostic methods--oculoplethysmography-carotid phonoangiography (OPG/CPA) and directional Doppler ultrasonography--to detect extracranial cerebrovascular disease was examined in 400 consecutive studies. Cerebral arteriography was performed in 74 patients. Transient ischemic attack was ...

journal_title：Neurology

authors： Ginsberg MD,Greenwood SA,Goldberg HI

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Quantitative head impulse test (HIT) measures the gain of the angular vestibulo-ocular reflex (VOR) during head rotation as the ratio of eye to head acceleration. Bedside HIT identifies subsequent catch-up saccades after the head rotation as indirect signs of VOR deficit. OBJECTIVE:To determine the VOR defi...

journal_title：Neurology

authors： Weber KP,Aw ST,Todd MJ,McGarvie LA,Curthoys IS,Halmagyi GM

更新日期：2008-02-05 00:00:00

abstract：OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...

journal_title：Neurology

authors： Venkateswaran S,Zheng K,Sacchetti M,Gagne D,Arnold DL,Sadovnick AD,Scherer SW,Banwell B,Bar-Or A,Simon DK,Canadian Pediatric Demyelinating Disease Network.

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To assess the feasibility of using MRI measurements as a surrogate endpoint for disease progression in a therapeutic trial for AD. METHODS:A total of 362 patients with probable AD from 38 different centers participated in the MRI portion of a 52-week randomized placebo-controlled trial of milameline, a musca...

journal_title：Neurology

authors： Jack CR Jr,Slomkowski M,Gracon S,Hoover TM,Felmlee JP,Stewart K,Xu Y,Shiung M,O'Brien PC,Cha R,Knopman D,Petersen RC

更新日期：2003-01-28 00:00:00

abstract：OBJECTIVE:Compare the cost and effectiveness of nonbenzodiazepine antiepileptic drugs (non-BZD AEDs) for treatment of BZD-resistant convulsive status epilepticus (SE). METHODS:Decision analysis model populated with effectiveness data from a systematic review and meta-analysis of the literature, and cost data from publ...

journal_title：Neurology

authors： Sánchez Fernández I,Gaínza-Lein M,Lamb N,Loddenkemper T

更新日期：2019-05-14 00:00:00

abstract：:Magnetic resonance images (MRI), evoked responses (ER), and CSF findings were compared in 39 patients with possible, probable, or definite MS. MRI disclosed multiple lesions (72%) more often than ERs (55%) in the total group of patients. In possible MS, MRI showed multiple lesions in 71%, and ER abnormalities were fou...

journal_title：Neurology

authors： Farlow MR,Markand ON,Edwards MK,Stevens JC,Kolar OJ

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:To determine the latency, magnitude, and duration of the long-duration response (LDR) to levodopa in PD in relationship to the administration of levodopa at different interdose intervals. METHODS:In six patients with PD, two different 15-day treatment regimens were used in which the drug was administered wit...

journal_title：Neurology

authors： Zappia M,Bosco D,Plastino M,Nicoletti G,Branca D,Oliveri RL,Aguglia U,Gambardella A,Quattrone A

更新日期：1999-08-11 00:00:00

abstract：OBJECTIVE:To examine metabolism during exercise in 2 patients with muscle phosphorylase kinase (PHK) deficiency and to further define the phenotype of this rare glycogen storage disease (GSD). METHODS:Patient 1 (39 years old) had mild exercise-induced forearm pain, and EMG showed a myopathic pattern. Patient 2 (69 yea...

journal_title：Neurology

authors： Preisler N,Orngreen MC,Echaniz-Laguna A,Laforet P,Lonsdorfer-Wolf E,Doutreleau S,Geny B,Akman HO,Dimauro S,Vissing J

更新日期：2012-01-24 00:00:00

abstract：:Manipulation of afferent inputs may temporarily modulate dystonic spasms. Ten patients with writer's cramp were enrolled in a double-blind, randomized, crossover study in which the effects of transcutaneous electrical stimulation (TENS) and placebo treatment were compared. Patients were evaluated using four measures o...

journal_title：Neurology

authors： Tinazzi M,Farina S,Bhatia K,Fiaschi A,Moretto G,Bertolasi L,Zarattini S,Smania N

更新日期：2005-06-14 00:00:00

abstract：:We measured the cerebral metabolic rate for glucose (CMRglc) with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in a 47-year-old man with trisomy 21 Down's syndrome (DS) and autopsy-confirmed Alzheimer's disease. Dementia was evident from a confirmed history of cognitive decline, memory loss, and pe...

journal_title：Neurology

authors： Schapiro MB,Ball MJ,Grady CL,Haxby JV,Kaye JA,Rapoport SI

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVES:Compensatory processes involving the recruitment of additional cerebral areas can limit cognitive impairment caused by brain damage as revealed by fMRI. Multiple sclerosis (MS) is characterized by frequent cognitive deficiencies and diffuse brain damage. Understanding the missing or disturbed processes resul...

journal_title：Neurology

authors： Bonnet MC,Allard M,Dilharreguy B,Deloire M,Petry KG,Brochet B

更新日期：2010-10-05 00:00:00

abstract：OBJECTIVE:Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hormone production would result in loss of the known neuroprotective...

journal_title：Neurology

authors： James ML,Langefeld CD,Sekar P,Moomaw CJ,Elkind MSV,Worrall BB,Sheth KN,Martini SR,Osborne J,Woo D,ERICH Investigators.

更新日期：2017-09-05 00:00:00

abstract：:Concentrations of cyclic adenosine 3',5' monophosphate (cAMP) were significantly lower in parkinsonian patients than in controls, but concentrations of guanosine 3',5' monophosphate (cGMP) were not altered. Both cAMP and cGMP levels were lower in patients with more severe symptoms on the left side of the body. Somatos...

journal_title：Neurology

authors： Volicer L,Beal MF,Direnfeld LK,Marquis JK,Albert ML

更新日期：1986-01-01 00:00:00

abstract：:Using a crossed-response task, monkeys with neglect induced by frontal lesions appear to have motor rather than sensory neglect. However, the crossed-response task may not reveal sensory neglect (inattention) if no perceptual discrimination is required. We therefore trained two monkeys in a perceptually complex crosse...

journal_title：Neurology

authors： Heilman KM,Valenstein E,Day A,Watson R

更新日期：1995-06-01 00:00:00

abstract：:Early motor manifestations are the main components of focal seizures involving the frontal lobe. We examined the relationship between the initial ictal motor manifestations and interictal abnormalities of cerebral glucose consumption (rCMRGlc) as assessed by PET in 48 consecutive patients with focal seizures of neocor...

journal_title：Neurology

authors： Schlaug G,Antke C,Holthausen H,Arnold S,Ebner A,Tuxhorn I,Jäncke L,Lüders H,Witte OW,Seitz RJ

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The best treatment for polyneuropathy associated with IgM monoclonal gammopathy (MGUS) is unknown. Oral cyclophosphamide combined with prednisone showed limited efficacy in a previous open label pilot study. We therefore performed a double-blind, randomized, placebo-controlled study of combined oral cyclopho...

journal_title：Neurology

authors： Niermeijer JM,Eurelings M,van der Linden MW,Lokhorst HM,Franssen H,Fischer K,Teunissen LL,van den Berg LH,Schobben F,Wokke JH,Notermans NC

更新日期：2007-07-03 00:00:00

abstract：OBJECTIVE:To validate, examine the internal validity, and adapt to children the electronic version of the composite cerebellar functional severity (CCFS) score. METHODS:In this multicenter study, we compared the validated manual device with the new electronic version (n = 46) and analyzed its kinetics in 146 patients ...

journal_title：Neurology

authors： Filipovic Pierucci A,Mariotti C,Panzeri M,Giunti P,Boesch S,Schulz JB,Pandolfo M,Durr A,Tezenas du Montcel S,EFACTS Study Group.

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Although the Mini-Mental State Examination (MMSE) is widely used in clinical practice, few norms exist for healthy populations covering a broad range of ages. OBJECTIVE:To obtain MMSE norms specific for age, gender, and education in healthy adults. METHODS:From the population registers of seven communities...

journal_title：Neurology

authors： Grigoletto F,Zappalà G,Anderson DW,Lebowitz BD

更新日期：1999-07-22 00:00:00

abstract：:A number of unresolved issues complicate the effective management of patients with Parkinson's disease (PD). Chief among these is the role of neuroprotective versus symptomatic pharmacologic interventions. Until the etiology of PD is further defined, consensus on appropriate management of this illness is unlikely. Cli...

journal_title：Neurology

authors： Stern MB

更新日期：1997-07-01 00:00:00

abstract：:The effect of bilateral frontal leukotomy on motor function was evaluated by neurologic examination, tests of praxis, and appropriate neuropsychologic tests administered to five groups of subjects. Postleukotomy schizophrenic patients were subdivided into three degrees of recovery. Two nonleukotomized groups served as...

journal_title：Neurology

authors： Benson DF,Stuss DT

更新日期：1982-12-01 00:00:00

abstract：:We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower...

journal_title：Neurology

authors： Nisipeanu P,Korczyn AD

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To describe two symptomatic dysferlin gene mutation carriers. METHODS:One patient had limb girdle weakness. His brother was diagnosed with limb girdle muscular dystrophy 2B with two mutations in the dysferlin gene (D625Y and E1734G). The second patient had distal weakness. He had two sons with Miyoshi myopat...

journal_title：Neurology

authors： Illa I,De Luna N,Domínguez-Perles R,Rojas-García R,Paradas C,Palmer J,Márquez C,Gallano P,Gallardo E

更新日期：2007-04-17 00:00:00

abstract：OBJECTIVE:Coccidioides species are the most common etiologic agents of chronic meningitis in regions endemic for coccidioidomycosis. Occasionally, even short-term travel to endemic regions results in the acquisition of meningeal disease, so awareness of this complication of coccidioidomycosis is important even in nonen...

journal_title：Neurology

authors： Drake KW,Adam RD

更新日期：2009-11-24 00:00:00

abstract：:We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...

journal_title：Neurology

authors： Amarenco P,Roullet E,Goujon C,Chéron F,Hauw JJ,Bousser MG

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to clarify the characteristic brain MRI findings for genetically diagnosed CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). METHODS:Seven patients with CARASIL carrying HTRA1 mutations (representing 6 Japanese families) we...

journal_title：Neurology

authors： Nozaki H,Sekine Y,Fukutake T,Nishimoto Y,Shimoe Y,Shirata A,Yanagawa S,Hirayama M,Tamura M,Nishizawa M,Onodera O

更新日期：2015-08-04 00:00:00

abstract：OBJECTIVE:Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. METHODS:We review the various mechani...

journal_title：Neurology

authors： Racke MK,Lovett-Racke AE,Karandikar NJ

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Demyelination alone may not explain the progressive disability that frequently develops in MS. An alternative explanation for irreversible disability assumes a contribution from axonal injury or loss. In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more di...

journal_title：Neurology

authors： Simon JH,Kinkel RP,Jacobs L,Bub L,Simonian N

更新日期：2000-03-14 00:00:00

abstract：:Using an in vitro blood-nerve barrier (BNB) model, the authors tested the effect of various monoclonal antiganglioside antibodies on BNB function. Only anti-GM1 antibody significantly facilitated BNB leakage in a concentration-dependent, complement-independent manner. This study provided evidence that anti-GM1 antibod...

journal_title：Neurology

authors： Kanda T,Iwasaki T,Yamawaki M,Tai T,Mizusawa H

更新日期：2000-08-22 00:00:00