Abstract:
OBJECTIVE:To describe two symptomatic dysferlin gene mutation carriers. METHODS:One patient had limb girdle weakness. His brother was diagnosed with limb girdle muscular dystrophy 2B with two mutations in the dysferlin gene (D625Y and E1734G). The second patient had distal weakness. He had two sons with Miyoshi myopathy with a homozygous mutation (G519R). We performed immunofluorescence (dystrophin, DAG proteins, dysferlin, caveolin-3), Western blot (dysferlin, caveolin-3, calpain-3), and real-time PCR (dysferlin) using skeletal muscle samples. We also studied dysferlin in peripheral blood monocytes (PBMs) by Western blot. RESULTS:In addition to the muscle weakness, both patients showed elevated creatine kinase and abnormal muscle MRI. They presented a mutation in only one allele after screening of the whole gene (skeletal muscle and monocyte mRNA and genomic DNA). A muscle biopsy specimen showed moderate dystrophic changes and patchy dysferlin expression in the sarcolemma. Western blot of both PBMs and skeletal muscle demonstrated a significant reduction in dysferlin. All the other proteins including caveolin-3 and calpain-3 were normal. Real-time PCR showed normal levels of dysferlin mRNA vs the patients' affected relatives. CONCLUSIONS:The diagnosis of symptomatic carriers of dysferlin mutations should be considered when a pathologic pattern of dysferlin protein is observed.
journal_name
Neurologyjournal_title
Neurologyauthors
Illa I,De Luna N,Domínguez-Perles R,Rojas-García R,Paradas C,Palmer J,Márquez C,Gallano P,Gallardo Edoi
10.1212/01.wnl.0000256768.79353.60subject
Has Abstractpub_date
2007-04-17 00:00:00pages
1284-9issue
16eissn
0028-3878issn
1526-632Xpii
01.wnl.0000256768.79353.60journal_volume
68pub_type
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