Abstract:
OBJECTIVE:To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population. METHODS:The authors assessed CH as defined by the second edition of the International Classification of Headache Disorders in 31,750 registered twins born from 1935 to 1958. Structured lay screening interviews were followed by neurologist interviews of possible cases. Co-twins of affected index twins were follow-up interviewed regardless of their screening outcome. RESULTS:A total of 250 screening-positives (0.8%) were found, of which 218 (88%) were follow-up interviewed. Forty-five (21%) had the CH diagnosis verified. Among screen-negatives, hospitalization records pointed at two more verified cases and index twins at one more verified case. A total of 48 CH cases provided a crude lifetime prevalence of 151 per 100,000 (95% CI: 108, 194). The male-to-female sex ratio corresponded to 4.8 (95% CI: 2.3, 9.9). The crude lifetime prevalence of CH was higher in the twins born from 1945 to 1958 than in the twins born from 1935 to 1944 (190 vs 90/100,000). CH recurred in 2 of 12 co-twins of monozygous index twins (including 1 nonparticipant twin), whereas all co-twins of 25 dizygous index twins proved to be unaffected. CONCLUSION:As many as 1 per 500 of the general population are affected by cluster headache. Twin concordance seems low, but genetic factors may play a role for familial clustering.
journal_name
Neurologyjournal_title
Neurologyauthors
Ekbom K,Svensson DA,Pedersen NL,Waldenlind Edoi
10.1212/01.wnl.0000233786.72356.3esubject
Has Abstractpub_date
2006-09-12 00:00:00pages
798-803issue
5eissn
0028-3878issn
1526-632Xpii
67/5/798journal_volume
67pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::We developed a method for the detection of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) carriers. The method is based on the quantitative analysis of the products of standard multiplex polymerase chain reaction (PCR) from 18 different exons of the dystrophin gene, and is designated "QM-PCR." W...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1783
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Demyelination alone may not explain the progressive disability that frequently develops in MS. An alternative explanation for irreversible disability assumes a contribution from axonal injury or loss. In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1155
更新日期:2000-03-14 00:00:00
abstract:OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy. METHODS:We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromuscular transm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000295
更新日期:2014-04-08 00:00:00
abstract:BACKGROUND:Few population-based studies with long-term follow-up have compared risk of recurrent stroke and cardiac events after first ischemic stroke. The relative risk of these two outcomes may inform treatment decisions. METHODS:In the population-based Northern Manhattan Study, first ischemic stroke patients age 40...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000201253.93811.f6
更新日期:2006-03-14 00:00:00
abstract::In vivo proton magnetic resonance spectroscopy (MRS) may be used to quantify brainstem neuronal degeneration in ALS because of the neuronal localization of N-acetylaspartate and N-acetylaspartylglutamate, together termed NA, which are estimated with this technique. We measured the ratio of NA to creatine/phosphocreati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.1.72
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN:The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.4.1000
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To investigate the genotype-phenotype correlation between neurofibromatosis 1 (NF1) germline mutations and imaging features of neurofibromas on whole-body MRI (WBMRI) by using radiomics image analysis techniques. MATERIALS AND METHODS:Twenty-nine patients with NF1 who had known germline mutations determined ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009490
更新日期:2020-06-16 00:00:00
abstract::Acetylcholinesterase (AChE) inhibitors were first administered in Europe to human subjects in the 1860s, and synthetic derivatives of the natural alkaloid inhibitors were developed in the 1930s to modulate peripheral cholinergic function. However, only within the last decade have these agents been systematically studi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.1_suppl_1.s30
更新日期:1998-07-01 00:00:00
abstract::We evaluated the relationship between mesial temporal seizure focus and serum prolactin (PRL) in patients before and after they underwent anterior temporal lobectomy (ATL) for medically intractable temporal lobe epilepsy (TLE). These patients had a confirmed unilateral epileptogenic focus in mesial temporal structures...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.528
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg daily vs the approved 20-mg formulation in relapsing-remitting multiple sclerosis. METHODS:Eligibility criteria included clinically definite multiple sclerosis, Expanded Disability Status Scale score 0 to 5.0, no previous use...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000257109.61671.06
更新日期:2007-03-20 00:00:00
abstract::Sorivudine provides a unique nucleoside analog with significantly enhanced both in vitro and in vitro activity and enhanced oral bioavailability. Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection a...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.45.12_suppl_8.s73
更新日期:1995-12-01 00:00:00
abstract::Original reports on temporal arteritis and polymyalgia rheumatica were reviewed before and after the introduction of steroid therapy to prevent blindness in temporal arteritis. In some cases, the original data were reworked. There is evidence that both diseases have become more benign. As a result, the perceived risk ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.46.4.901
更新日期:1996-04-01 00:00:00
abstract::To test interphysician agreement on the diagnosis of subtype of ischemic stroke, we sent subtype definitions and 18 case summaries (clinical features and pertinent laboratory data) to 24 neurologists who have a special interest in stroke, and asked them to determine the most likely subtype diagnosis. The overall agree...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.5.1021
更新日期:1993-05-01 00:00:00
abstract::We transplanted autologous adrenal medullary tissue into the caudate nucleus of 3 patients with advanced Parkinson's disease. The 1st patient, a 59-year-old man with parkinsonian symptoms for 15 years, had mild improvement in his motor functioning after the operation. However, his postoperative course was characterize...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.9.1227
更新日期:1989-09-01 00:00:00
abstract::The authors report an autosomal dominant episodic ataxia that is clinically distinct from the other episodic ataxias. Vestibular ataxia, vertigo, tinnitus, and interictal myokymia are prominent; attacks are diminished by acetazolamide. Linkage analyses of markers flanking the EA1 and EA2 loci demonstrate genetic exclu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.8.1499
更新日期:2001-10-23 00:00:00
abstract:OBJECTIVE:To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND:BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (ACh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.6.1608
更新日期:1998-12-01 00:00:00
abstract::Restless legs syndrome (RLS) is a common neurologic disorder whose prevalence has been estimated at 4 to 10% of the general population. Although its pathophysiology remains unknown, dopaminergic mechanisms are believed to play a central role. Furthermore, dopaminergic drugs have shown therapeutic efficacy in various l...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.61.6_suppl_3.s49
更新日期:2003-09-23 00:00:00
abstract:OBJECTIVE:To examine subjective versus objective memory change after anterior temporal lobectomy (ATL). METHODS:A prospective, controlled study. Controls included 39 unoperated patients with intractable temporal lobe epilepsy (TLE) who were administered a series of cognitive and health-related quality of life measures...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1511
更新日期:1999-10-22 00:00:00
abstract::Pure alexia, following an infarction in the distribution of the left posterior cerebral artery, is attributed to damage of the left occipital lobe and the splenium of the corpus callosum. We describe a case of pure alexia in a 57-year-old woman with infarction of the left lateral geniculate body and the splenium of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.4.587
更新日期:1991-04-01 00:00:00
abstract::Although a neuromuscular syndrome has been induced experimentally by vitamin E deficiency, a human syndrome has not yet been documented. This report describes a 7-year-old boy with severe malabsorption since birth who presented with progressive external ophthalmoplegia, proximal muscle weakness, peripheral neuropathy,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1182
更新日期:1979-08-01 00:00:00
abstract::A patient with a large acoustic neuroma had contralateral hemifacial spasm. On CT, the brainstem was markedly displaced and distorted by the tumor. After total removal of the tumor the hemifacial spasm was temporarily worse, but disappeared 14 days after the operation. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.2.339
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVES:To study the behavioral and neuroanatomic characteristics of perseverative behavior encountered on a target cancellation task in patients with neglect. METHODS:Motor perseverative behavior during line cancellation task was evaluated retrospectively in 60 patients with left hemispatial neglect from right hem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.8.1569
更新日期:1999-05-12 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of onabotulinumtoxinA 100 U in noncatheterizing patients with multiple sclerosis (MS) with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS:In this randomized, double-blind phase III study, patients received onabotulinumtoxinA 100 U (n = 66)...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000005991
更新日期:2018-08-14 00:00:00
abstract:OBJECTIVES:This study aims to investigate if patients with inflammatory neuropathies and tremor have evidence of dysfunction in the cerebellum and interactions in sensorimotor cortex compared to nontremulous patients and healthy controls. METHODS:A prospective data collection study investigating patients with inflamma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318292a2b8
更新日期:2013-05-14 00:00:00
abstract:OBJECTIVE:Using interictal alpha-[11C]methyl-l-tryptophan ([11C]AMT) PET scan, the authors have undertaken a quantitative analysis of all tubers visible on MRI or 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET, to determine the relationship between [11C]AMT uptake and epileptic activity on EEG. BACKGROUND:Tuberous scl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.10.1976
更新日期:2000-05-23 00:00:00
abstract:OBJECTIVE:The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions. ME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a6cbfe
更新日期:2013-10-01 00:00:00
abstract::We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, si...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.3.221
更新日期:1976-03-01 00:00:00
abstract::We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1311
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2. METHODS:VGKC-positive patients were tested for LGI1 and Caspr2 antibodies. Patients lacking both antibodies were matched (1:2) to VGKC-negative patients. Clinical and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002637
更新日期:2016-05-03 00:00:00
abstract::We reviewed the prognostic significance of preoperative EEG findings in 25 patients who underwent functional hemispherectomy. Bilateral independent epileptogenic foci, found in five patients, generally indicate a less satisfactory outcome, with only three of the five patients becoming seizure free following hemisphere...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.11.1790
更新日期:1991-11-01 00:00:00