Abstract:
OBJECTIVE:To examine subjective versus objective memory change after anterior temporal lobectomy (ATL). METHODS:A prospective, controlled study. Controls included 39 unoperated patients with intractable temporal lobe epilepsy (TLE) who were administered a series of cognitive and health-related quality of life measures at baseline and at 12-month follow-up intervals. The surgery sample included 65 patients with intractable, focal TLE who had undergone either a right or left ATL. These patients were tested preoperatively and at 6-month follow-up intervals. Subjective and objective memory change was quantified using a newly developed methodology to control for practice effect and regression to the mean. RESULTS:Measures of subjective and objective memory change were not significantly related in the surgery sample. Prevalence of significant subjective memory decline 1 year after surgery ranged from 3 to 7%, whereas prevalence of significant objective memory decline ranged from 26 to 55%. Postoperative levels of emotional distress significantly predicted self-reported memory decline 1 year after ATL. Postoperative medication side effect and seizure outcome were also related significantly to subjective memory change in patients who had undergone left ATL. CONCLUSIONS:Subjective and objective memory change after temporal lobectomy are not related. Complaints of significant memory decline after ATL are infrequent and may serve as a marker for depression or other mood disorder rather than organically based memory decline.
journal_name
Neurologyjournal_title
Neurologyauthors
Sawrie SM,Martin RC,Kuzniecky R,Faught E,Morawetz R,Jamil F,Viikinsalo M,Gilliam Fdoi
10.1212/wnl.53.7.1511subject
Has Abstractpub_date
1999-10-22 00:00:00pages
1511-7issue
7eissn
0028-3878issn
1526-632Xjournal_volume
53pub_type
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