Abstract:
OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, papilledema, and weight at the baseline evaluation and at 6 months or longer. Patients were divided into two groups based on whether weight loss > or = 2.5 kg occurred during any 3-month interval. Papilledema grade, visual acuity, and visual field grade at 6 months or longer and the time to improve each were recorded. RESULTS:Mean time in months to improve one grade for papilledema and visual field in one eye was 4.0 versus 6.7 (p = 0.013) and 4.6 versus 12.2 (p = 0.032), respectively, for the 38 patients with weight loss compared with the 20 patients with no weight loss. Papilledema resolved in 28/38 with weight loss (mean, 7.6 months) and 8/20 without weight loss (mean, 10.2 months; p = 0.352). There were no differences in final visual acuity or visual field between the two groups, but the papilledema grade was slightly better in the worst eye in each patient at baseline in the weight loss group (p = 0.03). CONCLUSIONS:Weight reduction is associated with more rapid recovery of both papilledema and visual field dysfunction in patients with IIH compared with those who do not lose weight.
journal_name
Neurologyjournal_title
Neurologyauthors
Kupersmith MJ,Gamell L,Turbin R,Peck V,Spiegel P,Wall Mdoi
10.1212/wnl.50.4.1094subject
Has Abstractpub_date
1998-04-01 00:00:00pages
1094-8issue
4eissn
0028-3878issn
1526-632Xjournal_volume
50pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:Hospital readmission is an important quality improvement measure that has not been well-studied in pediatric neurology. We examined predictors of 7-day and 30-day readmissions for pediatric patients hospitalized with a neurologic diagnosis. METHODS:This was a retrospective study of hospital readmission rates...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007280
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:To study the accuracy of the ABCD2 score in predicting early stroke risk following TIA and to model post-test probability of stroke for varying cutoff scores and baseline stroke risk. METHODS:Medline, PubMed, Embase, conference proceedings, and manuscript references up to October 2010 were searched for studi...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0b013e31825f9d02
更新日期:2012-09-04 00:00:00
abstract::The presence of the APOE epsilon 4 allele encoding apolipoprotein E4 (apoE4) is the major genetic risk factor for late-onset Alzheimer's disease (AD). However, the molecular and cellular mechanisms by which APOE epsilon 4 renders AD risk are unclear. In this report, we present genetic evidence that an apoE receptor, L...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.56
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:This study analyzed the relationship between performance on the American Academy of Neurology Residency In-Service Training Examination (RITE) and subsequent performance on the American Board of Psychiatry and Neurology (ABPN) Certification Examination. METHODS:Pearson correlation coefficients were used to e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b92a3
更新日期:2013-01-08 00:00:00
abstract::This community-based study analyzed 54 patients with definite or probable tuberculous meningitis (TBM) in New Mexico from 1970 through 1990. Patients ranged in age from 4 months to 86 years. The highest age-specific incidence occurred in the elderly, but 22% of patients were less than 10 years old. Native American pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.9.1775
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:The authors imaged the medial longitudinal fasciculus (MLF) in 58 patients with MS and chronic internuclear ophthalmoparesis (INO) to determine which MRI technique best shows the characteristic lesion associated with this ocular motor syndrome. METHODS:Using quantitative infrared oculography, the authors det...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.762
更新日期:2001-09-11 00:00:00
abstract:OBJECTIVE:To examine the association between socioeconomic status (SES) and disability outcomes and progression in multiple sclerosis (MS). METHODS:Health administrative and MS clinical data were linked for 2 cohorts of patients with MS in British Columbia (Canada) and South East Wales (UK). SES was measured at MS sym...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007190
更新日期:2019-03-26 00:00:00
abstract:OBJECTIVE:We hypothesized that cardiac electrical instability and abnormal autonomic tone result from cumulative cardiac injury sustained in recurrent seizures. We tested this hypothesis by comparing T-wave alternans (TWA) and heart rate variability (HRV), both established markers of sudden cardiac death (SCD) risk, in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008077
更新日期:2019-09-03 00:00:00
abstract::We have identified large-scale deletions in muscle mitochondrial DNA (mtDNA) in seven of seven patients with Kearns-Sayre syndrome (KSS). We found no detectable deletions in the mtDNA of ten non-KSS patients with other mitochondrial myopathies or encephalomyopathies, or three normal controls. The deletions ranged in s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1339
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:To undertake an effectiveness and safety analysis of EVT in patients with LVO and NIH Stroke Scale (NIHSS) score ≤6 using datasets of multicenter and multinational nature. METHODS:We pooled patients with anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presen...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000010955
更新日期:2020-12-15 00:00:00
abstract::An emerging issue in stroke prevention and stroke treatment is that therapies shown to be effective in clinical trials are not being used or are being used suboptimally. One of many explanations relates to cost, ranging from concerns about inappropriate use of societal resources to more immediate concerns of organizat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.3_suppl_3.s31
更新日期:1998-09-01 00:00:00
abstract::The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.10.952
更新日期:1976-10-01 00:00:00
abstract:OBJECTIVES:To evaluate basal ganglia changes along the amyotrophic lateral sclerosis (ALS)-ALS-frontotemporal dementia (FTD) continuum using multiple, complementary imaging techniques. METHODS:Sixty-seven C9orf72-negative patients with ALS and 39 healthy controls were included in a cross-sectional quantitative MRI stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002017
更新日期:2015-10-13 00:00:00
abstract:OBJECTIVE:To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine. METHODS:This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients wit...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000147290.68260.11
更新日期:2004-12-28 00:00:00
abstract::Previous brain infarctions seen on CT are common in the absence of history of stroke. Eleven percent of patients (135/1,203) without stroke history had ischemic lesions on their first CT, unrelated to the presenting stroke. Stroke Data Bank files were reviewed to determine whether the occurrence, location, and CT char...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.11.1674
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs). Whether it affects neurofibrillary tangle (NFT) accumulation or cholinergic losses in AD remains co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000128091.92139.0f
更新日期:2004-06-08 00:00:00
abstract::In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1311
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term outcome of patients with spinal cord infarct (SCI) and identify prognostic predictors. METHODS:We reviewed 115 patients with SCI treated between 1990 and 2007. Severity of impairment was defined using the American Spinal Injury Association (ASIA) scoring. Functional outcome endpo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823efc93
更新日期:2012-01-10 00:00:00
abstract:OBJECTIVE:To investigate the association between early depressive behavior after stroke onset and occurrence of poststroke depression (PSD) at 3- and 12-month follow-up evaluations. METHODS:The study prospectively included 273 patients with first-ever single uncomplicated ischemic stroke. In the stroke unit, nurses sc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150935.05940.2D
更新日期:2005-02-08 00:00:00
abstract:OBJECTIVE:To evaluate the risk of recurrent intracranial hemorrhage (ICH) in patients on vitamin K antagonists (VKAs) after a first episode of ICH. METHODS:The Cerebral Haemorrhage in patients Restarting Oral Anticoagulant Therapy (CHIRONE) Study collected data of patients eligible for the study from the database of 2...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000000245
更新日期:2014-03-25 00:00:00
abstract::It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000078195.05396.20
更新日期:2003-08-26 00:00:00
abstract:OBJECTIVE:To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer disease (AD), and mild cognitive impairment (MCI) using fMRI. METHODS:This prospective cohort study included 40 patients with CAA, 22 with AD, 27 with MCI, and 25 healthy contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010201
更新日期:2020-09-08 00:00:00
abstract::We report the cases of 5 patients from 2 sibships with the "adult" or chronic form of GM2 gangliosidosis and 2 patients from another sibship with the juvenile form. We demonstrated hexosaminidase A deficiency in all cases but in 1 sibship the enzymatic profile was identical to that in Tay-Sachs disease, whereas in the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.145
更新日期:1990-01-01 00:00:00
abstract::Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.4.529
更新日期:2001-02-27 00:00:00
abstract:OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c33afb
更新日期:2009-11-24 00:00:00
abstract::Acute myopathy and myoglobinuria with markedly elevated creatine kinase (CK) activity developed in an 18-year-old boy on two occasions after gasoline sniffing. No signs of CNS involvement were seen, and the symptoms receded in a few days. The amount of lead in blood and urine exceeded the reference value for subjects ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.5.629
更新日期:1983-05-01 00:00:00
abstract::Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the ove...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.8.901
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVES:To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel cor...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000009632
更新日期:2020-06-09 00:00:00
abstract:OBJECTIVE:To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND:The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.1.82
更新日期:2001-01-09 00:00:00
abstract::To gain insight into the historical features relevant to the diagnosis of cardiac embolic strokes, we studied the 1,290 patients with cerebral infarcts in the NINCDS Stroke Data Bank. Based solely on the presence of cardiac sources of embolism, we divided the patients into groups of high (n = 250), medium (n = 166), a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.2.281
更新日期:1990-02-01 00:00:00